61 Publikationen
2024 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 12402
Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. Chemie Ingenieur Technik. 2024;96(4):528-534. doi:10.1002/cite.202300188
ELSA
| DOI
| WoS
2023 | Konferenz - Poster | ELSA-ID: 11381
Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. DECHEMA e.V.
ELSA
2023 | Konferenz - Poster | ELSA-ID: 11382 |

Gassenmeier V, Kuhfuß F, Deppe S, Ifrim G, Hernández Rodriguez T, Frahm B. View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks.
ELSA
| Download (ext.)
2023 | Konferenz - Vortrag | ELSA-ID: 11383
Hernández Rodriguez T, Posch C, Pörtner R, Lange-Hegermann M, Wurm FM, Frahm B. Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture. DECHEMA e.V.; 2023.
ELSA
2023 | Konferenz - Poster | ELSA-ID: 11487 |

Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression . DECHEMA e.V.
ELSA
| Download (ext.)
2023 | Konferenz - Poster | ELSA-ID: 10201 |

Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development.; 2023.
ELSA
| Download (ext.)
2023 | Konferenzband - Beitrag | ELSA-ID: 10788 |

Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. (Jasperneite J, Wisniewski L, Fung Man K, Institute of Electrical and Electronics Engineers , eds.). IEEE; 2023:1-6. doi:10.1109/INDIN51400.2023.10218012
ELSA
| DOI
| Download (ext.)
2023 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11385
Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. Chemie Ingenieur Technik. 2023;95(12):1960-1969. doi:10.1002/cite.202300082
ELSA
| DOI
| WoS
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11377
Hernández Rodriguez T, Sekulic A, Lange-Hegermann M, Frahm B. Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. Processes. 2022;10(5). doi:10.3390/pr10050883
ELSA
| DOI
2022 | Konferenz - Poster | ELSA-ID: 7932
Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development.
ELSA
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7976
Gassenmeier V, Deppe S, Hernández Rodriguez T, et al. Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. Current Research in Biotechnology. 2022;4:102-119. doi:10.1016/j.crbiot.2022.01.005
ELSA
| DOI
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7977
Kuhfuß F, Gassenmeier V, Deppe S, Ifrim GA, Hernández Rodriguez T, Frahm B. View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. Bioprocess and Biosystems Engineering. 2022;45:15-30. doi:10.1007/s00449-021-02627-2
ELSA
| DOI
2022 | Sammelwerk - Beitrag | ELSA-ID: 10193
Hernández Rodriguez T, Sekulic A, Lange-Hegermann M, Frahm B. Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In: Pörtner R, Möller J, eds. Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing. Vol special issue. Processes : open access journal. MDPI; 2022:21-48. doi:https://doi.org/10.3390/pr10050883
ELSA
| DOI
2022 | Konferenz - Vortrag | ELSA-ID: 10197
Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Model Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture.; 2022.
ELSA
2022 | Konferenz - Poster | ELSA-ID: 10198
Hernández Rodriguez T, Pörtner R, Lange-Hegermann M, Wurm FM, Frahm B. A Systematic, Model-Based Approach for Decision Making in Upstream Development – Considerations Regarding Clone Selection and Cell Expansion.
ELSA
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11376
Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. Processes. 2021;9(6). doi:10.3390/pr9060964
ELSA
| DOI
2021 | Konferenz - Vortrag | ELSA-ID: 7927
Hernández Rodriguez T, Frahm B. Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction.; 2021.
ELSA
2021 | Konferenz - Poster | ELSA-ID: 7931
Moser A, Möller J, Kuchemüller KB, et al. Model-Assisted Design of Experiments - Concept, Software and Applications.; 2021.
ELSA
2021 | Sammelwerk - Beitrag | ELSA-ID: 7983
Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing. Vol special issue. Processes : open access journal . MDPI; 2021:49-74. doi:10.3390/pr9060964
ELSA
| DOI
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering. 2021;44(4):793-808. doi:10.1007/s00449-020-02488-1
ELSA
| DOI
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7986
Moser A, Kuchemüller KB, Deppe S, et al. Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering. 2021;44(4):683-700. doi:10.1007/s00449-020-02478-3
ELSA
| DOI
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
Hernández Rodriguez T, Frahm B. Digital Seed Train Twins and Statistical Methods. In: Herwig C, Pörtner R, Möller J, eds. Digital Twins Tools and Concepts for Smart Biomanufacturing. Vol 176. Advances in Biochemical Engineering/Biotechnology. Springer; 2021:97-131. doi:https://doi.org/10.1007/10_2020_137
ELSA
| DOI
2020 | Konferenz - Poster | ELSA-ID: 7929
Hernández Rodriguez T, Deppe S, Gassenmeier V, et al. Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration.; 2020.
ELSA
2020 | Konferenz - Poster | ELSA-ID: 7930
Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes.; 2020.
ELSA
2020 | Konferenz - Vortrag | ELSA-ID: 7936
Hernández Rodriguez T, Frahm B, Posch C. Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support.; 2020.
ELSA
2020 | Konferenzband - Beitrag | ELSA-ID: 7937
Hernández Rodriguez T, Deppe S, Gassenmeier V, et al. Modeling of Chlorella Vulgaris Algae in Shake Flasks with Respect to Light Intensity and Light Duration. Vol No. 9. Wiley; 2020:1225 – 1226. doi:10.1002/cite.202055235
ELSA
| DOI
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes. Vol No. 9. Wiley; 2020:1241 – 1242. doi:10.1002/cite.202055234
ELSA
| DOI
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
Hernández Rodriguez T, Posch C, Schmutzhard J, et al. Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach. Vol 14. BioMed Central; 2020:P408. doi:10.1186/s12919-020-00188-y
ELSA
| Dateien verfügbar
| DOI
2020 | Konferenz - Poster | ELSA-ID: 3007
Kuhfuß F, Tölle M, Hernández Rodriguez T, et al. Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration.; 2020.
ELSA
2020 | Konferenz - Poster | ELSA-ID: 3008
Deppe S, Kuhfuß F, Tölle M, et al. Model-Assisted Design of Experiments for Algae Cultivation.; 2020.
ELSA
2020 | Konferenz - Poster | ELSA-ID: 3009
Ifrim GA, Deppe S, Hernández Rodriguez T, Gassenmeier V, Frahm B. Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production.; 2020.
ELSA
2019 | Konferenz - Vortrag | ELSA-ID: 2956
Möller J, Müller J, Hernández Rodriguez T, et al. Workflow for Model-Assisted Design and Scale-up of Biopharmaceutical Production Processes.; 2019.
ELSA
2019 | Konferenz - Vortrag | ELSA-ID: 2957
Möller J, Kuchemüller KB, Moser A, et al. Model-Assisted Design of Experiments.; 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3000
Hernández Rodriguez T, Posch C, Schmutzhard J, et al. Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating.; 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3001
Hernández Rodriguez T, Posch C, Schmutzhard J, et al. Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating.; 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3002
Möller J, Kuchemüller KB, Hernández Rodriguez T, et al. Model-Assisted Design of Experiments – Software Toolbox.; 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3003
Deppe S, Hernández Rodriguez T, Gassenmeier V, et al. Model-Assisted Design of Experiments for Algae Cultivation.; 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3004
Ifrim GA, Deppe S, Hernández Rodriguez T, Gassenmeier V, Frahm B. Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production.; 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3005
Hernández Rodriguez T, Posch C, Schmutzhard J, et al. Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating.; 2019.
ELSA
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 |

Hernández Rodriguez T, Posch C, Schmutzhard J, et al. Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method. Biotechnology and Bioengineering. 2019;116(11):2944-2959. doi:10.1002/bit.27125
ELSA
| DOI
| Download (ext.)
2018 | Konferenz - Vortrag | ELSA-ID: 7935
Hernández Rodriguez T, Frahm B, Posch C, Schmutzhard J, Stettner J. A Model-Assisted Approach for Design, Optimization and Control of Bioprocesses – a Software Tool for Seed Train Simulation and Optimization.; 2018.
ELSA
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
Hernández Rodriguez T, Krull S, Hass VC, Möller J, Pörtner R, Frahm B. Model-Assisted Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization. Vol 112. BioMed Central; 2018:P175. doi:10.1186/s12919-018-0097-x
ELSA
| Dateien verfügbar
| DOI
2018 | Konferenz - Poster | ELSA-ID: 2997
Möller J, Kuchemüller KB, Freiberger F, et al. Model-Assisted Design and Optimization of Process Strategies.; 2018.
ELSA
2018 | Konferenz - Poster | ELSA-ID: 2999
Hernández Rodriguez T, Möller J, Kuchemüller KB, et al. Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses.; 2018.
ELSA
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 |

Möller J, Kuchemüller KB, Hernández Rodriguez T, Frahm B, Hass VC, Pörtner R. Model-Assisted Design of Process Strategies for Cell Culture Processes. American Pharmaceutical Review. 2018;3:39-41.
ELSA
| Download (ext.)
2017 | Konferenz - Vortrag | ELSA-ID: 2920
Hernández Rodriguez T, Kern S, Platas Barradas O, Pörtner R, Frahm B. Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren.; 2017.
ELSA
2017 | Konferenz - Vortrag | ELSA-ID: 2921
Pörtner R, Möller J, Hernández Rodriguez T, Frahm B, Hass VC. Model-Assisted Design and Optimization of Biotechnological Processes.; 2017.
ELSA
2017 | Konferenz - Vortrag | ELSA-ID: 2950
Hernández Rodriguez T, Koopmann KS, Klaes J, et al. Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren.; 2017.
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2994
Hernández Rodriguez T, Koopmann KS, Pörtner R, Frahm B. Influence of Parameter Accuracies in Cell Culture Seed Train Simulations.; 2017.
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2995
Hernández Rodriguez T, Krull S, Hass VC, Möller J, Pörtner R, Frahm B. Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization.; 2017.
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2996
Hernández Rodriguez T, Krull S, Hass VC, Pörtner R, Frahm B. Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization.; 2017.
ELSA
2016 | Konferenz - Poster | ELSA-ID: 2992
Hernández Rodriguez T, Vörtler S, Kern S, Platas Barradas O, Pörtner R, Frahm B. A Software Tool for Biopharmaceutical Seed Train Design and Optimization.; 2016.
ELSA
2016 | Konferenz - Poster | ELSA-ID: 2993
Koopmann KS, Hernández Rodriguez T, Vörtler S, et al. Simulation of Cell Culture Seed Trains – Investigation of the Influence of Parameter Inaccuracies.; 2016.
ELSA
2015 | Konferenzband - Beitrag | ELSA-ID: 2819 |

Hernández Rodriguez T, Pörtner R, Frahm B. Considerations for Cell Passaging in Cell Culture Seed Trains. Vol 9. BioMed Central; 2015. doi:10.1186/1753-6561-9-s9-p43
ELSA
| DOI
| Download (ext.)
2015 | Konferenz - Vortrag | ELSA-ID: 2917
Frahm B, Pörtner R, Kern S, Hernández Rodriguez T. Seed Train Design and Optimization for Animal Cell Suspension Culture.; 2015.
ELSA
| Dateien verfügbar
2015 | Konferenz - Vortrag | ELSA-ID: 2919
Frahm B, Hernández Rodriguez T, Kern S, et al. Seed Train Design and Optimization for Animal Cell Suspension Culture.; 2015.
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2985
Hernández Rodriguez T, Pörtner R, Frahm B. Considerations for Cell Passaging in Cell Culture Seed Trains.; 2015.
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2987
Hernández Rodriguez T, Pörtner R, Frahm B. A Software Tool for Biopharmaceutical Seed Train Design and Optimization.; 2015.
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2988
Hernández Rodriguez T, Pörtner R, Frahm B. Considerations for Cell Passaging in Cell Culture Seed Trains.; 2015.
ELSA
2013 | Konferenzband - Beitrag | ELSA-ID: 2817 |

Hernández Rodriguez T, Pörtner R, Frahm B. Seed Train Optimization for Suspension Cell Culture. Vol 7. BioMed Central ; 2013. doi:10.1186/1753-6561-7-s6-p9
ELSA
| DOI
| Download (ext.)
2013 | Konferenz - Poster | ELSA-ID: 2983
Hernández Rodriguez T, Pörtner R, Frahm B. Seed Train Optimization for Suspension Cell Culture.; 2013.
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61 Publikationen
2024 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 12402
Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. Chemie Ingenieur Technik. 2024;96(4):528-534. doi:10.1002/cite.202300188
ELSA
| DOI
| WoS
2023 | Konferenz - Poster | ELSA-ID: 11381
Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. DECHEMA e.V.
ELSA
2023 | Konferenz - Poster | ELSA-ID: 11382 |

Gassenmeier V, Kuhfuß F, Deppe S, Ifrim G, Hernández Rodriguez T, Frahm B. View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks.
ELSA
| Download (ext.)
2023 | Konferenz - Vortrag | ELSA-ID: 11383
Hernández Rodriguez T, Posch C, Pörtner R, Lange-Hegermann M, Wurm FM, Frahm B. Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture. DECHEMA e.V.; 2023.
ELSA
2023 | Konferenz - Poster | ELSA-ID: 11487 |

Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression . DECHEMA e.V.
ELSA
| Download (ext.)
2023 | Konferenz - Poster | ELSA-ID: 10201 |

Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development.; 2023.
ELSA
| Download (ext.)
2023 | Konferenzband - Beitrag | ELSA-ID: 10788 |

Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. (Jasperneite J, Wisniewski L, Fung Man K, Institute of Electrical and Electronics Engineers , eds.). IEEE; 2023:1-6. doi:10.1109/INDIN51400.2023.10218012
ELSA
| DOI
| Download (ext.)
2023 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11385
Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. Chemie Ingenieur Technik. 2023;95(12):1960-1969. doi:10.1002/cite.202300082
ELSA
| DOI
| WoS
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11377
Hernández Rodriguez T, Sekulic A, Lange-Hegermann M, Frahm B. Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. Processes. 2022;10(5). doi:10.3390/pr10050883
ELSA
| DOI
2022 | Konferenz - Poster | ELSA-ID: 7932
Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development.
ELSA
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7976
Gassenmeier V, Deppe S, Hernández Rodriguez T, et al. Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. Current Research in Biotechnology. 2022;4:102-119. doi:10.1016/j.crbiot.2022.01.005
ELSA
| DOI
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7977
Kuhfuß F, Gassenmeier V, Deppe S, Ifrim GA, Hernández Rodriguez T, Frahm B. View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. Bioprocess and Biosystems Engineering. 2022;45:15-30. doi:10.1007/s00449-021-02627-2
ELSA
| DOI
2022 | Sammelwerk - Beitrag | ELSA-ID: 10193
Hernández Rodriguez T, Sekulic A, Lange-Hegermann M, Frahm B. Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In: Pörtner R, Möller J, eds. Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing. Vol special issue. Processes : open access journal. MDPI; 2022:21-48. doi:https://doi.org/10.3390/pr10050883
ELSA
| DOI
2022 | Konferenz - Vortrag | ELSA-ID: 10197
Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Model Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture.; 2022.
ELSA
2022 | Konferenz - Poster | ELSA-ID: 10198
Hernández Rodriguez T, Pörtner R, Lange-Hegermann M, Wurm FM, Frahm B. A Systematic, Model-Based Approach for Decision Making in Upstream Development – Considerations Regarding Clone Selection and Cell Expansion.
ELSA
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11376
Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. Processes. 2021;9(6). doi:10.3390/pr9060964
ELSA
| DOI
2021 | Konferenz - Vortrag | ELSA-ID: 7927
Hernández Rodriguez T, Frahm B. Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction.; 2021.
ELSA
2021 | Konferenz - Poster | ELSA-ID: 7931
Moser A, Möller J, Kuchemüller KB, et al. Model-Assisted Design of Experiments - Concept, Software and Applications.; 2021.
ELSA
2021 | Sammelwerk - Beitrag | ELSA-ID: 7983
Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing. Vol special issue. Processes : open access journal . MDPI; 2021:49-74. doi:10.3390/pr9060964
ELSA
| DOI
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering. 2021;44(4):793-808. doi:10.1007/s00449-020-02488-1
ELSA
| DOI
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7986
Moser A, Kuchemüller KB, Deppe S, et al. Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering. 2021;44(4):683-700. doi:10.1007/s00449-020-02478-3
ELSA
| DOI
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
Hernández Rodriguez T, Frahm B. Digital Seed Train Twins and Statistical Methods. In: Herwig C, Pörtner R, Möller J, eds. Digital Twins Tools and Concepts for Smart Biomanufacturing. Vol 176. Advances in Biochemical Engineering/Biotechnology. Springer; 2021:97-131. doi:https://doi.org/10.1007/10_2020_137
ELSA
| DOI
2020 | Konferenz - Poster | ELSA-ID: 7929
Hernández Rodriguez T, Deppe S, Gassenmeier V, et al. Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration.; 2020.
ELSA
2020 | Konferenz - Poster | ELSA-ID: 7930
Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes.; 2020.
ELSA
2020 | Konferenz - Vortrag | ELSA-ID: 7936
Hernández Rodriguez T, Frahm B, Posch C. Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support.; 2020.
ELSA
2020 | Konferenzband - Beitrag | ELSA-ID: 7937
Hernández Rodriguez T, Deppe S, Gassenmeier V, et al. Modeling of Chlorella Vulgaris Algae in Shake Flasks with Respect to Light Intensity and Light Duration. Vol No. 9. Wiley; 2020:1225 – 1226. doi:10.1002/cite.202055235
ELSA
| DOI
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes. Vol No. 9. Wiley; 2020:1241 – 1242. doi:10.1002/cite.202055234
ELSA
| DOI
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
Hernández Rodriguez T, Posch C, Schmutzhard J, et al. Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach. Vol 14. BioMed Central; 2020:P408. doi:10.1186/s12919-020-00188-y
ELSA
| Dateien verfügbar
| DOI
2020 | Konferenz - Poster | ELSA-ID: 3007
Kuhfuß F, Tölle M, Hernández Rodriguez T, et al. Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration.; 2020.
ELSA
2020 | Konferenz - Poster | ELSA-ID: 3008
Deppe S, Kuhfuß F, Tölle M, et al. Model-Assisted Design of Experiments for Algae Cultivation.; 2020.
ELSA
2020 | Konferenz - Poster | ELSA-ID: 3009
Ifrim GA, Deppe S, Hernández Rodriguez T, Gassenmeier V, Frahm B. Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production.; 2020.
ELSA
2019 | Konferenz - Vortrag | ELSA-ID: 2956
Möller J, Müller J, Hernández Rodriguez T, et al. Workflow for Model-Assisted Design and Scale-up of Biopharmaceutical Production Processes.; 2019.
ELSA
2019 | Konferenz - Vortrag | ELSA-ID: 2957
Möller J, Kuchemüller KB, Moser A, et al. Model-Assisted Design of Experiments.; 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3000
Hernández Rodriguez T, Posch C, Schmutzhard J, et al. Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating.; 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3001
Hernández Rodriguez T, Posch C, Schmutzhard J, et al. Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating.; 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3002
Möller J, Kuchemüller KB, Hernández Rodriguez T, et al. Model-Assisted Design of Experiments – Software Toolbox.; 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3003
Deppe S, Hernández Rodriguez T, Gassenmeier V, et al. Model-Assisted Design of Experiments for Algae Cultivation.; 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3004
Ifrim GA, Deppe S, Hernández Rodriguez T, Gassenmeier V, Frahm B. Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production.; 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3005
Hernández Rodriguez T, Posch C, Schmutzhard J, et al. Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating.; 2019.
ELSA
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 |

Hernández Rodriguez T, Posch C, Schmutzhard J, et al. Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method. Biotechnology and Bioengineering. 2019;116(11):2944-2959. doi:10.1002/bit.27125
ELSA
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2018 | Konferenz - Vortrag | ELSA-ID: 7935
Hernández Rodriguez T, Frahm B, Posch C, Schmutzhard J, Stettner J. A Model-Assisted Approach for Design, Optimization and Control of Bioprocesses – a Software Tool for Seed Train Simulation and Optimization.; 2018.
ELSA
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
Hernández Rodriguez T, Krull S, Hass VC, Möller J, Pörtner R, Frahm B. Model-Assisted Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization. Vol 112. BioMed Central; 2018:P175. doi:10.1186/s12919-018-0097-x
ELSA
| Dateien verfügbar
| DOI
2018 | Konferenz - Poster | ELSA-ID: 2997
Möller J, Kuchemüller KB, Freiberger F, et al. Model-Assisted Design and Optimization of Process Strategies.; 2018.
ELSA
2018 | Konferenz - Poster | ELSA-ID: 2999
Hernández Rodriguez T, Möller J, Kuchemüller KB, et al. Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses.; 2018.
ELSA
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 |

Möller J, Kuchemüller KB, Hernández Rodriguez T, Frahm B, Hass VC, Pörtner R. Model-Assisted Design of Process Strategies for Cell Culture Processes. American Pharmaceutical Review. 2018;3:39-41.
ELSA
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2017 | Konferenz - Vortrag | ELSA-ID: 2920
Hernández Rodriguez T, Kern S, Platas Barradas O, Pörtner R, Frahm B. Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren.; 2017.
ELSA
2017 | Konferenz - Vortrag | ELSA-ID: 2921
Pörtner R, Möller J, Hernández Rodriguez T, Frahm B, Hass VC. Model-Assisted Design and Optimization of Biotechnological Processes.; 2017.
ELSA
2017 | Konferenz - Vortrag | ELSA-ID: 2950
Hernández Rodriguez T, Koopmann KS, Klaes J, et al. Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren.; 2017.
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2994
Hernández Rodriguez T, Koopmann KS, Pörtner R, Frahm B. Influence of Parameter Accuracies in Cell Culture Seed Train Simulations.; 2017.
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2995
Hernández Rodriguez T, Krull S, Hass VC, Möller J, Pörtner R, Frahm B. Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization.; 2017.
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2996
Hernández Rodriguez T, Krull S, Hass VC, Pörtner R, Frahm B. Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization.; 2017.
ELSA
2016 | Konferenz - Poster | ELSA-ID: 2992
Hernández Rodriguez T, Vörtler S, Kern S, Platas Barradas O, Pörtner R, Frahm B. A Software Tool for Biopharmaceutical Seed Train Design and Optimization.; 2016.
ELSA
2016 | Konferenz - Poster | ELSA-ID: 2993
Koopmann KS, Hernández Rodriguez T, Vörtler S, et al. Simulation of Cell Culture Seed Trains – Investigation of the Influence of Parameter Inaccuracies.; 2016.
ELSA
2015 | Konferenzband - Beitrag | ELSA-ID: 2819 |

Hernández Rodriguez T, Pörtner R, Frahm B. Considerations for Cell Passaging in Cell Culture Seed Trains. Vol 9. BioMed Central; 2015. doi:10.1186/1753-6561-9-s9-p43
ELSA
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2015 | Konferenz - Vortrag | ELSA-ID: 2917
Frahm B, Pörtner R, Kern S, Hernández Rodriguez T. Seed Train Design and Optimization for Animal Cell Suspension Culture.; 2015.
ELSA
| Dateien verfügbar
2015 | Konferenz - Vortrag | ELSA-ID: 2919
Frahm B, Hernández Rodriguez T, Kern S, et al. Seed Train Design and Optimization for Animal Cell Suspension Culture.; 2015.
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2985
Hernández Rodriguez T, Pörtner R, Frahm B. Considerations for Cell Passaging in Cell Culture Seed Trains.; 2015.
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2987
Hernández Rodriguez T, Pörtner R, Frahm B. A Software Tool for Biopharmaceutical Seed Train Design and Optimization.; 2015.
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2988
Hernández Rodriguez T, Pörtner R, Frahm B. Considerations for Cell Passaging in Cell Culture Seed Trains.; 2015.
ELSA
2013 | Konferenzband - Beitrag | ELSA-ID: 2817 |

Hernández Rodriguez T, Pörtner R, Frahm B. Seed Train Optimization for Suspension Cell Culture. Vol 7. BioMed Central ; 2013. doi:10.1186/1753-6561-7-s6-p9
ELSA
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2013 | Konferenz - Poster | ELSA-ID: 2983
Hernández Rodriguez T, Pörtner R, Frahm B. Seed Train Optimization for Suspension Cell Culture.; 2013.
ELSA