61 Publikationen
2024 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 12402
Kosse, Pascal ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Lübken, Manfred ; Wichern, Marc: Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. In: Chemie Ingenieur Technik Bd. 96. Weinheim, Wiley (2024), Nr. 4, S. 528–534
ELSA
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2023 | Konferenz - Poster | ELSA-ID: 11381
Hernández Rodriguez, Tanja ; Ramm, Selina ; Lange-Hegermann, Markus ; Frahm, Björn: A systematic, model-based workflow for risk-based decision making in upstream development : DECHEMA e.V.
ELSA
2023 | Konferenz - Poster | ELSA-ID: 11382 |

Gassenmeier, Veronika ; Kuhfuß, Fabian ; Deppe, Sahar ; Ifrim, George ; Hernández Rodriguez, Tanja ; Frahm, Björn: View on a mechanistic model of Chlorella vulgaris in shake flasks
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2023 | Konferenz - Vortrag | ELSA-ID: 11383
Hernández Rodriguez, Tanja ; Posch, Christoph ; Pörtner, Ralf ; Lange-Hegermann, Markus ; Wurm, Florian M. ; Frahm, Björn: Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture : DECHEMA e.V., 2023
ELSA
2023 | Konferenz - Poster | ELSA-ID: 11487 |

Ramm, Selina ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Pein-Hackelbusch, Miriam: Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression : DECHEMA e.V.
ELSA
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2023 | Konferenz - Poster | ELSA-ID: 10201 |

Hernández Rodriguez, Tanja ; Ramm, Selina ; Lange-Hegermann, Markus ; Frahm, Björn: A systematic, model-based workflow for risk-based decision making in upstream development, 2023
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2023 | Konferenzband - Beitrag | ELSA-ID: 10788 |

Ramm, Selina ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Pein-Hackelbusch, Miriam ; Jasperneite, J. ; Wisniewski, L. ; Fung Man, K. ; Institute of Electrical and Electronics Engineers (Hrsg.): Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. [Piscataway, NJ] : IEEE, 2023
ELSA
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2023 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11385
Kosse, Pascal ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Lübken, Manfred ; Wichern, Marc: Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. In: Chemie Ingenieur Technik Bd. 95. Weinheim, Wiley (2023), Nr. 12, S. 1960–1969
ELSA
| DOI
| WoS
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11377
Hernández Rodriguez, Tanja ; Sekulic, Anton ; Lange-Hegermann, Markus ; Frahm, Björn: Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. In: Processes Bd. 10. Basel, MDPI AG (2022), Nr. 5
ELSA
| DOI
2022 | Konferenz - Poster | ELSA-ID: 7932
Hernández Rodriguez, Tanja ; Ramm, Selina ; Lange-Hegermann, Markus ; Frahm, Björn: A systematic, model-based workflow for risk-based decision making in upstream development
ELSA
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7976
Gassenmeier, Veronika ; Deppe, Sahar ; Hernández Rodriguez, Tanja ; Kuhfuß, Fabian ; Moser, André ; Hass, Volker C. ; Kuchemüller, Kim B. ; Pörtner, Ralf ; u. a.: Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. In: Current Research in Biotechnology Bd. 4, Elsevier (2022), S. 102–119
ELSA
| DOI
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7977
Kuhfuß, Fabian ; Gassenmeier, Veronika ; Deppe, Sahar ; Ifrim, George Adrian ; Hernández Rodriguez, Tanja ; Frahm, Björn: View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. In: Bioprocess and Biosystems Engineering Bd. 45. Berlin, Springer (2022), S. 15–30
ELSA
| DOI
2022 | Sammelwerk - Beitrag | ELSA-ID: 10193
Hernández Rodriguez, Tanja ; Sekulic, Anton ; Lange-Hegermann, Markus ; Frahm, Björn: Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In: Pörtner, R. ; Möller, J. (Hrsg.): Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, Processes : open access journal. Bd. special issue. Basel : MDPI, 2022, S. 21–48
ELSA
| DOI
2022 | Konferenz - Vortrag | ELSA-ID: 10197
Hernández Rodriguez, Tanja ; Posch, Christoph ; Pörtner, Ralf ; Frahm, Björn: Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture, 2022
ELSA
2022 | Konferenz - Poster | ELSA-ID: 10198
Hernández Rodriguez, Tanja ; Pörtner, Ralf ; Lange-Hegermann, Markus ; Wurm, Florian M. ; Frahm, Björn: A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion
ELSA
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11376
Hernández Rodriguez, Tanja ; Morerod, Sophie ; Pörtner, Ralf ; Wurm, Florian M. ; Frahm, Björn: Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. In: Processes Bd. 9. Basel, MDPI AG (2021), Nr. 6
ELSA
| DOI
2021 | Konferenz - Vortrag | ELSA-ID: 7927
Hernández Rodriguez, Tanja ; Frahm, Björn: Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction, 2021
ELSA
2021 | Konferenz - Poster | ELSA-ID: 7931
Moser, André ; Möller, Johannes ; Kuchemüller, Kim B. ; Deppe, Sahar ; Hernández Rodriguez, Tanja ; Gassenmeier, Veronika ; Ifrim, George Adrian ; Frahm, Björn ; u. a.: Model-assisted Design of Experiments - Concept, Software and Applications, 2021
ELSA
2021 | Sammelwerk - Beitrag | ELSA-ID: 7983
Hernández Rodriguez, Tanja ; Morerod, Sophie ; Pörtner, Ralf ; Wurm, Florian M. ; Frahm, Björn: Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, Processes : open access journal . Bd. special issue. Basel : MDPI, 2021, S. 49–74
ELSA
| DOI
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
Hernández Rodriguez, Tanja ; Posch, Christoph ; Pörtner, Ralf ; Frahm, Björn: Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. In: Bioprocess and Biosystems Engineering Bd. 44. Berlin ; Heidelberg [u.a.], Springer (2021), Nr. 4, S. 793–808
ELSA
| DOI
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7986
Moser, André ; Kuchemüller, Kim B. ; Deppe, Sahar ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Pörtner, Ralf ; Hass, Volker C. ; Möller, Johannes: Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. In: Bioprocess and Biosystems Engineering Bd. 44. Berlin ; Heidelberg [u.a.], Springer (2021), Nr. 4, S. 683–700
ELSA
| DOI
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
Hernández Rodriguez, Tanja ; Frahm, Björn: Digital Seed Train Twins and Statistical Methods. In: Herwig, C. ; Pörtner, R. ; Möller, J. (Hrsg.): Digital Twins Tools and Concepts for Smart Biomanufacturing, Advances in Biochemical Engineering/Biotechnology. Bd. 176. Berlin, Heidelberg : Springer, 2021, S. 97–131
ELSA
| DOI
2020 | Konferenz - Poster | ELSA-ID: 7929
Hernández Rodriguez, Tanja ; Deppe, Sahar ; Gassenmeier, Veronika ; Kuhfuß, Fabian ; Tölle, Marius ; Ifrim, George Adrian ; Frahm, Björn: Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration, 2020
ELSA
2020 | Konferenz - Poster | ELSA-ID: 7930
Hernández Rodriguez, Tanja ; Posch, Christoph ; Pörtner, Ralf ; Frahm, Björn: Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes, 2020
ELSA
2020 | Konferenz - Vortrag | ELSA-ID: 7936
Hernández Rodriguez, Tanja ; Frahm, Björn ; Posch, Christoph: Integration of prior knowledge and digital tools for uncertainty-based decision support, 2020
ELSA
2020 | Konferenzband - Beitrag | ELSA-ID: 7937
Hernández Rodriguez, Tanja ; Deppe, Sahar ; Gassenmeier, Veronika ; Kuhfuß, Fabian ; Tölle, Marius ; Ifrim, George Adrian ; Frahm, Björn: Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration, Volume 92. Bd. No. 9 : Wiley, 2020
ELSA
| DOI
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
Hernández Rodriguez, Tanja ; Posch, Christoph ; Pörtner, Ralf ; Frahm, Björn: Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes, Volume 92. Bd. No. 9 : Wiley, 2020
ELSA
| DOI
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
Hernández Rodriguez, Tanja ; Posch, Christoph ; Schmutzhard, Julia ; Stettner, Josef ; Weihs, Claus ; Pörtner, Ralf ; Frahm, Björn: Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach. Bd. 14 : BioMed Central, 2020
ELSA
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| DOI
2020 | Konferenz - Poster | ELSA-ID: 3007
Kuhfuß, F. ; Tölle, M. ; Hernández Rodriguez, Tanja ; Gassenmeier, Veronika ; Deppe, S. ; Ifrim, George Adrian ; Frahm, Björn: Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration, 2020
ELSA
2020 | Konferenz - Poster | ELSA-ID: 3008
Deppe, S. ; Kuhfuß, F. ; Tölle, M. ; Hernández Rodriguez, Tanja ; Gassenmeier, Veronika ; Ifrim, George Adrian ; Möller, J. ; Pörtner, R. ; u. a.: Model-assisted Design of Experiments for algae cultivation, 2020
ELSA
2020 | Konferenz - Poster | ELSA-ID: 3009
Ifrim, George Adrian ; Deppe, S. ; Hernández Rodriguez, Tanja ; Gassenmeier, Veronika ; Frahm, Björn: Modeling of microalgae in an air-lift photobioreactor for biomass production, 2020
ELSA
2019 | Konferenz - Vortrag | ELSA-ID: 2956
Möller, J. ; Müller, J. ; Hernández Rodriguez, Tanja ; Kuchemüller, K. B. ; Arndt, L. ; Frahm, Björn ; Eibl, R. ; Eibl, D. ; u. a.: Workflow for model-assisted design and scale-up of biopharmaceutical production processes, 2019
ELSA
2019 | Konferenz - Vortrag | ELSA-ID: 2957
Möller, J. ; Kuchemüller, K. B. ; Moser, A. ; Hass, V. C. ; Hernández Rodriguez, Tanja ; Deppe, S. ; Frahm, Björn ; Pörtner, R.: Model-Assisted Design of Experiments, 2019
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3000
Hernández Rodriguez, Tanja ; Posch, C. ; Schmutzhard, J. ; Stettner, J. ; Weihs, J. ; Pörtner, R. ; Frahm, Björn: Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3001
Hernández Rodriguez, Tanja ; Posch, C. ; Schmutzhard, J. ; Stettner, J. ; Weihs, J. ; Pörtner, R. ; Frahm, Björn: Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3002
Möller, J. ; Kuchemüller, K. B. ; Hernández Rodriguez, Tanja ; Deppe, S. ; Ifrim, George Adrian ; Moser, A. ; Hass, V. C. ; Frahm, Björn ; u. a.: Model-Assisted Design of Experiments – Software Toolbox, 2019
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3003
Deppe, S. ; Hernández Rodriguez, Tanja ; Gassenmeier, Veronika ; Tölle, M. ; Kuhfuß, F. ; Möller, J. ; Kuchemüller, K. B. ; Pörtner, R. ; u. a.: Model-assisted Design of Experiments for algae cultivation, 2019
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3004
Ifrim, George Adrian ; Deppe, S. ; Hernández Rodriguez, Tanja ; Gassenmeier, Veronika ; Frahm, Björn: Modeling of microalgae in an air-lift photobioreactor for biomass production, 2019
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3005
Hernández Rodriguez, Tanja ; Posch, C. ; Schmutzhard, J. ; Stettner, J. ; Weihs, J. ; Pörtner, R. ; Frahm, Björn: Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019
ELSA
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 |

Hernández Rodriguez, Tanja ; Posch, Christoph ; Schmutzhard, Julia ; Stettner, Josef ; Weihs, Claus ; Pörtner, Ralf ; Frahm, Björn: Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method. In: Biotechnology and Bioengineering Bd. 116, Wiley (2019), Nr. 11, S. 2944–2959
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2018 | Konferenz - Vortrag | ELSA-ID: 7935
Hernández Rodriguez, Tanja ; Frahm, Björn ; Posch, Christoph ; Schmutzhard, Julia ; Stettner, Josef: A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization, 2018
ELSA
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
Hernández Rodriguez, Tanja ; Krull, Susan ; Hass, Volker C. ; Möller, Johannes ; Pörtner, Ralf ; Frahm, Björn: Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. Bd. 112 : BioMed Central, 2018
ELSA
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2018 | Konferenz - Poster | ELSA-ID: 2997
Möller, J. ; Kuchemüller, K. B. ; Freiberger, F. ; Levermann, P. ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Hass, V. C. ; Pörtner, R.: Model-Assisted Design and Optimization of Process Strategies, 2018
ELSA
2018 | Konferenz - Poster | ELSA-ID: 2999
Hernández Rodriguez, Tanja ; Möller, J. ; Kuchemüller, K. B. ; Freiberger, F. ; Levermann, P. ; Hass, V. C. ; Frahm, Björn ; Pörtner, R.: Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses, 2018
ELSA
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 |

Möller, J. ; Kuchemüller, K. B. ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Hass, V. C. ; Pörtner, R. : Model-Assisted Design of Process Strategies for Cell Culture Processes. In: American Pharmaceutical Review Bd. 3, Russel (2018), S. 39–41
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2017 | Konferenz - Vortrag | ELSA-ID: 2920
Hernández Rodriguez, Tanja ; Kern, S. ; Platas Barradas, O. ; Pörtner, R. ; Frahm, Björn: Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017
ELSA
2017 | Konferenz - Vortrag | ELSA-ID: 2921
Pörtner, R. ; Möller, J. ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Hass, V. C.: Model-assisted design and optimization of biotechnological processes, 2017
ELSA
2017 | Konferenz - Vortrag | ELSA-ID: 2950
Hernández Rodriguez, Tanja ; Koopmann, K. S. ; Klaes, J. ; Kern, S. ; Platas Barradas, O. ; Pörtner, R. ; Frahm, Björn: Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2994
Hernández Rodriguez, Tanja ; Koopmann, K. S. ; Pörtner, R. ; Frahm, Björn: Influence of parameter accuracies in cell culture seed train simulations, 2017
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2995
Hernández Rodriguez, Tanja ; Krull, S. ; Hass, V. C. ; Möller, J. ; Pörtner, R. ; Frahm, Björn: Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization, 2017
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2996
Hernández Rodriguez, Tanja ; Krull, S. ; Hass, V. C. ; Pörtner, R. ; Frahm, Björn: Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization, 2017
ELSA
2016 | Konferenz - Poster | ELSA-ID: 2992
Hernández Rodriguez, Tanja ; Vörtler, S. ; Kern, S. ; Platas Barradas, O. ; Pörtner, R. ; Frahm, Björn: A software tool for biopharmaceutical seed train design and optimization, 2016
ELSA
2016 | Konferenz - Poster | ELSA-ID: 2993
Koopmann, K. S. ; Hernández Rodriguez, Tanja ; Vörtler, S. ; Beshay, U. ; Möller, J. ; Pörtner, R. ; Frahm, Björn: Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies, 2016
ELSA
2015 | Konferenzband - Beitrag | ELSA-ID: 2819 |

Hernández Rodriguez, Tanja ; Pörtner, Ralf ; Frahm, Björn: Considerations for cell passaging in cell culture seed trains. Bd. 9 : BioMed Central, 2015
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2015 | Konferenz - Vortrag | ELSA-ID: 2917
Frahm, Björn ; Pörtner, R. ; Kern, S. ; Hernández Rodriguez, Tanja: Seed train design and optimization for animal cell suspension culture, 2015
ELSA
| Dateien verfügbar
2015 | Konferenz - Vortrag | ELSA-ID: 2919
Frahm, Björn ; Hernández Rodriguez, Tanja ; Kern, S. ; Koopmann, K. S. ; Beshay, U. ; Platas-Barradas, O. ; Pörtner, R.: Seed train design and optimization for animal cell suspension culture, 2015
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2985
Hernández Rodriguez, Tanja ; Pörtner, R. ; Frahm, Björn: Considerations for cell passaging in cell culture seed trains, 2015
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2987
Hernández Rodriguez, Tanja ; Pörtner, R. ; Frahm, Björn: A software tool for biopharmaceutical seed train design and optimization, 2015
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2988
Hernández Rodriguez, Tanja ; Pörtner, R. ; Frahm, Björn: Considerations for cell passaging in cell culture seed trains, 2015
ELSA
2013 | Konferenzband - Beitrag | ELSA-ID: 2817 |

Hernández Rodriguez, Tanja ; Pörtner, Ralf ; Frahm, Björn: Seed train optimization for suspension cell culture. Bd. 7 : BioMed Central , 2013
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2013 | Konferenz - Poster | ELSA-ID: 2983
Hernández Rodriguez, Tanja ; Pörtner, R. ; Frahm, Björn: Seed train optimization for suspension cell culture, 2013
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61 Publikationen
2024 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 12402
Kosse, Pascal ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Lübken, Manfred ; Wichern, Marc: Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. In: Chemie Ingenieur Technik Bd. 96. Weinheim, Wiley (2024), Nr. 4, S. 528–534
ELSA
| DOI
| WoS
2023 | Konferenz - Poster | ELSA-ID: 11381
Hernández Rodriguez, Tanja ; Ramm, Selina ; Lange-Hegermann, Markus ; Frahm, Björn: A systematic, model-based workflow for risk-based decision making in upstream development : DECHEMA e.V.
ELSA
2023 | Konferenz - Poster | ELSA-ID: 11382 |

Gassenmeier, Veronika ; Kuhfuß, Fabian ; Deppe, Sahar ; Ifrim, George ; Hernández Rodriguez, Tanja ; Frahm, Björn: View on a mechanistic model of Chlorella vulgaris in shake flasks
ELSA
| Download (ext.)
2023 | Konferenz - Vortrag | ELSA-ID: 11383
Hernández Rodriguez, Tanja ; Posch, Christoph ; Pörtner, Ralf ; Lange-Hegermann, Markus ; Wurm, Florian M. ; Frahm, Björn: Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture : DECHEMA e.V., 2023
ELSA
2023 | Konferenz - Poster | ELSA-ID: 11487 |

Ramm, Selina ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Pein-Hackelbusch, Miriam: Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression : DECHEMA e.V.
ELSA
| Download (ext.)
2023 | Konferenz - Poster | ELSA-ID: 10201 |

Hernández Rodriguez, Tanja ; Ramm, Selina ; Lange-Hegermann, Markus ; Frahm, Björn: A systematic, model-based workflow for risk-based decision making in upstream development, 2023
ELSA
| Download (ext.)
2023 | Konferenzband - Beitrag | ELSA-ID: 10788 |

Ramm, Selina ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Pein-Hackelbusch, Miriam ; Jasperneite, J. ; Wisniewski, L. ; Fung Man, K. ; Institute of Electrical and Electronics Engineers (Hrsg.): Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. [Piscataway, NJ] : IEEE, 2023
ELSA
| DOI
| Download (ext.)
2023 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11385
Kosse, Pascal ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Lübken, Manfred ; Wichern, Marc: Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. In: Chemie Ingenieur Technik Bd. 95. Weinheim, Wiley (2023), Nr. 12, S. 1960–1969
ELSA
| DOI
| WoS
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11377
Hernández Rodriguez, Tanja ; Sekulic, Anton ; Lange-Hegermann, Markus ; Frahm, Björn: Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. In: Processes Bd. 10. Basel, MDPI AG (2022), Nr. 5
ELSA
| DOI
2022 | Konferenz - Poster | ELSA-ID: 7932
Hernández Rodriguez, Tanja ; Ramm, Selina ; Lange-Hegermann, Markus ; Frahm, Björn: A systematic, model-based workflow for risk-based decision making in upstream development
ELSA
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7976
Gassenmeier, Veronika ; Deppe, Sahar ; Hernández Rodriguez, Tanja ; Kuhfuß, Fabian ; Moser, André ; Hass, Volker C. ; Kuchemüller, Kim B. ; Pörtner, Ralf ; u. a.: Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. In: Current Research in Biotechnology Bd. 4, Elsevier (2022), S. 102–119
ELSA
| DOI
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7977
Kuhfuß, Fabian ; Gassenmeier, Veronika ; Deppe, Sahar ; Ifrim, George Adrian ; Hernández Rodriguez, Tanja ; Frahm, Björn: View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. In: Bioprocess and Biosystems Engineering Bd. 45. Berlin, Springer (2022), S. 15–30
ELSA
| DOI
2022 | Sammelwerk - Beitrag | ELSA-ID: 10193
Hernández Rodriguez, Tanja ; Sekulic, Anton ; Lange-Hegermann, Markus ; Frahm, Björn: Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In: Pörtner, R. ; Möller, J. (Hrsg.): Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, Processes : open access journal. Bd. special issue. Basel : MDPI, 2022, S. 21–48
ELSA
| DOI
2022 | Konferenz - Vortrag | ELSA-ID: 10197
Hernández Rodriguez, Tanja ; Posch, Christoph ; Pörtner, Ralf ; Frahm, Björn: Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture, 2022
ELSA
2022 | Konferenz - Poster | ELSA-ID: 10198
Hernández Rodriguez, Tanja ; Pörtner, Ralf ; Lange-Hegermann, Markus ; Wurm, Florian M. ; Frahm, Björn: A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion
ELSA
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11376
Hernández Rodriguez, Tanja ; Morerod, Sophie ; Pörtner, Ralf ; Wurm, Florian M. ; Frahm, Björn: Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. In: Processes Bd. 9. Basel, MDPI AG (2021), Nr. 6
ELSA
| DOI
2021 | Konferenz - Vortrag | ELSA-ID: 7927
Hernández Rodriguez, Tanja ; Frahm, Björn: Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction, 2021
ELSA
2021 | Konferenz - Poster | ELSA-ID: 7931
Moser, André ; Möller, Johannes ; Kuchemüller, Kim B. ; Deppe, Sahar ; Hernández Rodriguez, Tanja ; Gassenmeier, Veronika ; Ifrim, George Adrian ; Frahm, Björn ; u. a.: Model-assisted Design of Experiments - Concept, Software and Applications, 2021
ELSA
2021 | Sammelwerk - Beitrag | ELSA-ID: 7983
Hernández Rodriguez, Tanja ; Morerod, Sophie ; Pörtner, Ralf ; Wurm, Florian M. ; Frahm, Björn: Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, Processes : open access journal . Bd. special issue. Basel : MDPI, 2021, S. 49–74
ELSA
| DOI
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
Hernández Rodriguez, Tanja ; Posch, Christoph ; Pörtner, Ralf ; Frahm, Björn: Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. In: Bioprocess and Biosystems Engineering Bd. 44. Berlin ; Heidelberg [u.a.], Springer (2021), Nr. 4, S. 793–808
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| DOI
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7986
Moser, André ; Kuchemüller, Kim B. ; Deppe, Sahar ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Pörtner, Ralf ; Hass, Volker C. ; Möller, Johannes: Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. In: Bioprocess and Biosystems Engineering Bd. 44. Berlin ; Heidelberg [u.a.], Springer (2021), Nr. 4, S. 683–700
ELSA
| DOI
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
Hernández Rodriguez, Tanja ; Frahm, Björn: Digital Seed Train Twins and Statistical Methods. In: Herwig, C. ; Pörtner, R. ; Möller, J. (Hrsg.): Digital Twins Tools and Concepts for Smart Biomanufacturing, Advances in Biochemical Engineering/Biotechnology. Bd. 176. Berlin, Heidelberg : Springer, 2021, S. 97–131
ELSA
| DOI
2020 | Konferenz - Poster | ELSA-ID: 7929
Hernández Rodriguez, Tanja ; Deppe, Sahar ; Gassenmeier, Veronika ; Kuhfuß, Fabian ; Tölle, Marius ; Ifrim, George Adrian ; Frahm, Björn: Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration, 2020
ELSA
2020 | Konferenz - Poster | ELSA-ID: 7930
Hernández Rodriguez, Tanja ; Posch, Christoph ; Pörtner, Ralf ; Frahm, Björn: Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes, 2020
ELSA
2020 | Konferenz - Vortrag | ELSA-ID: 7936
Hernández Rodriguez, Tanja ; Frahm, Björn ; Posch, Christoph: Integration of prior knowledge and digital tools for uncertainty-based decision support, 2020
ELSA
2020 | Konferenzband - Beitrag | ELSA-ID: 7937
Hernández Rodriguez, Tanja ; Deppe, Sahar ; Gassenmeier, Veronika ; Kuhfuß, Fabian ; Tölle, Marius ; Ifrim, George Adrian ; Frahm, Björn: Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration, Volume 92. Bd. No. 9 : Wiley, 2020
ELSA
| DOI
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
Hernández Rodriguez, Tanja ; Posch, Christoph ; Pörtner, Ralf ; Frahm, Björn: Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes, Volume 92. Bd. No. 9 : Wiley, 2020
ELSA
| DOI
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
Hernández Rodriguez, Tanja ; Posch, Christoph ; Schmutzhard, Julia ; Stettner, Josef ; Weihs, Claus ; Pörtner, Ralf ; Frahm, Björn: Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach. Bd. 14 : BioMed Central, 2020
ELSA
| Dateien verfügbar
| DOI
2020 | Konferenz - Poster | ELSA-ID: 3007
Kuhfuß, F. ; Tölle, M. ; Hernández Rodriguez, Tanja ; Gassenmeier, Veronika ; Deppe, S. ; Ifrim, George Adrian ; Frahm, Björn: Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration, 2020
ELSA
2020 | Konferenz - Poster | ELSA-ID: 3008
Deppe, S. ; Kuhfuß, F. ; Tölle, M. ; Hernández Rodriguez, Tanja ; Gassenmeier, Veronika ; Ifrim, George Adrian ; Möller, J. ; Pörtner, R. ; u. a.: Model-assisted Design of Experiments for algae cultivation, 2020
ELSA
2020 | Konferenz - Poster | ELSA-ID: 3009
Ifrim, George Adrian ; Deppe, S. ; Hernández Rodriguez, Tanja ; Gassenmeier, Veronika ; Frahm, Björn: Modeling of microalgae in an air-lift photobioreactor for biomass production, 2020
ELSA
2019 | Konferenz - Vortrag | ELSA-ID: 2956
Möller, J. ; Müller, J. ; Hernández Rodriguez, Tanja ; Kuchemüller, K. B. ; Arndt, L. ; Frahm, Björn ; Eibl, R. ; Eibl, D. ; u. a.: Workflow for model-assisted design and scale-up of biopharmaceutical production processes, 2019
ELSA
2019 | Konferenz - Vortrag | ELSA-ID: 2957
Möller, J. ; Kuchemüller, K. B. ; Moser, A. ; Hass, V. C. ; Hernández Rodriguez, Tanja ; Deppe, S. ; Frahm, Björn ; Pörtner, R.: Model-Assisted Design of Experiments, 2019
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3000
Hernández Rodriguez, Tanja ; Posch, C. ; Schmutzhard, J. ; Stettner, J. ; Weihs, J. ; Pörtner, R. ; Frahm, Björn: Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3001
Hernández Rodriguez, Tanja ; Posch, C. ; Schmutzhard, J. ; Stettner, J. ; Weihs, J. ; Pörtner, R. ; Frahm, Björn: Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3002
Möller, J. ; Kuchemüller, K. B. ; Hernández Rodriguez, Tanja ; Deppe, S. ; Ifrim, George Adrian ; Moser, A. ; Hass, V. C. ; Frahm, Björn ; u. a.: Model-Assisted Design of Experiments – Software Toolbox, 2019
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3003
Deppe, S. ; Hernández Rodriguez, Tanja ; Gassenmeier, Veronika ; Tölle, M. ; Kuhfuß, F. ; Möller, J. ; Kuchemüller, K. B. ; Pörtner, R. ; u. a.: Model-assisted Design of Experiments for algae cultivation, 2019
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3004
Ifrim, George Adrian ; Deppe, S. ; Hernández Rodriguez, Tanja ; Gassenmeier, Veronika ; Frahm, Björn: Modeling of microalgae in an air-lift photobioreactor for biomass production, 2019
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3005
Hernández Rodriguez, Tanja ; Posch, C. ; Schmutzhard, J. ; Stettner, J. ; Weihs, J. ; Pörtner, R. ; Frahm, Björn: Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019
ELSA
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 |

Hernández Rodriguez, Tanja ; Posch, Christoph ; Schmutzhard, Julia ; Stettner, Josef ; Weihs, Claus ; Pörtner, Ralf ; Frahm, Björn: Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method. In: Biotechnology and Bioengineering Bd. 116, Wiley (2019), Nr. 11, S. 2944–2959
ELSA
| DOI
| Download (ext.)
2018 | Konferenz - Vortrag | ELSA-ID: 7935
Hernández Rodriguez, Tanja ; Frahm, Björn ; Posch, Christoph ; Schmutzhard, Julia ; Stettner, Josef: A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization, 2018
ELSA
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
Hernández Rodriguez, Tanja ; Krull, Susan ; Hass, Volker C. ; Möller, Johannes ; Pörtner, Ralf ; Frahm, Björn: Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. Bd. 112 : BioMed Central, 2018
ELSA
| Dateien verfügbar
| DOI
2018 | Konferenz - Poster | ELSA-ID: 2997
Möller, J. ; Kuchemüller, K. B. ; Freiberger, F. ; Levermann, P. ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Hass, V. C. ; Pörtner, R.: Model-Assisted Design and Optimization of Process Strategies, 2018
ELSA
2018 | Konferenz - Poster | ELSA-ID: 2999
Hernández Rodriguez, Tanja ; Möller, J. ; Kuchemüller, K. B. ; Freiberger, F. ; Levermann, P. ; Hass, V. C. ; Frahm, Björn ; Pörtner, R.: Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses, 2018
ELSA
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 |

Möller, J. ; Kuchemüller, K. B. ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Hass, V. C. ; Pörtner, R. : Model-Assisted Design of Process Strategies for Cell Culture Processes. In: American Pharmaceutical Review Bd. 3, Russel (2018), S. 39–41
ELSA
| Download (ext.)
2017 | Konferenz - Vortrag | ELSA-ID: 2920
Hernández Rodriguez, Tanja ; Kern, S. ; Platas Barradas, O. ; Pörtner, R. ; Frahm, Björn: Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017
ELSA
2017 | Konferenz - Vortrag | ELSA-ID: 2921
Pörtner, R. ; Möller, J. ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Hass, V. C.: Model-assisted design and optimization of biotechnological processes, 2017
ELSA
2017 | Konferenz - Vortrag | ELSA-ID: 2950
Hernández Rodriguez, Tanja ; Koopmann, K. S. ; Klaes, J. ; Kern, S. ; Platas Barradas, O. ; Pörtner, R. ; Frahm, Björn: Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2994
Hernández Rodriguez, Tanja ; Koopmann, K. S. ; Pörtner, R. ; Frahm, Björn: Influence of parameter accuracies in cell culture seed train simulations, 2017
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2995
Hernández Rodriguez, Tanja ; Krull, S. ; Hass, V. C. ; Möller, J. ; Pörtner, R. ; Frahm, Björn: Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization, 2017
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2996
Hernández Rodriguez, Tanja ; Krull, S. ; Hass, V. C. ; Pörtner, R. ; Frahm, Björn: Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization, 2017
ELSA
2016 | Konferenz - Poster | ELSA-ID: 2992
Hernández Rodriguez, Tanja ; Vörtler, S. ; Kern, S. ; Platas Barradas, O. ; Pörtner, R. ; Frahm, Björn: A software tool for biopharmaceutical seed train design and optimization, 2016
ELSA
2016 | Konferenz - Poster | ELSA-ID: 2993
Koopmann, K. S. ; Hernández Rodriguez, Tanja ; Vörtler, S. ; Beshay, U. ; Möller, J. ; Pörtner, R. ; Frahm, Björn: Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies, 2016
ELSA
2015 | Konferenzband - Beitrag | ELSA-ID: 2819 |

Hernández Rodriguez, Tanja ; Pörtner, Ralf ; Frahm, Björn: Considerations for cell passaging in cell culture seed trains. Bd. 9 : BioMed Central, 2015
ELSA
| DOI
| Download (ext.)
2015 | Konferenz - Vortrag | ELSA-ID: 2917
Frahm, Björn ; Pörtner, R. ; Kern, S. ; Hernández Rodriguez, Tanja: Seed train design and optimization for animal cell suspension culture, 2015
ELSA
| Dateien verfügbar
2015 | Konferenz - Vortrag | ELSA-ID: 2919
Frahm, Björn ; Hernández Rodriguez, Tanja ; Kern, S. ; Koopmann, K. S. ; Beshay, U. ; Platas-Barradas, O. ; Pörtner, R.: Seed train design and optimization for animal cell suspension culture, 2015
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2985
Hernández Rodriguez, Tanja ; Pörtner, R. ; Frahm, Björn: Considerations for cell passaging in cell culture seed trains, 2015
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2987
Hernández Rodriguez, Tanja ; Pörtner, R. ; Frahm, Björn: A software tool for biopharmaceutical seed train design and optimization, 2015
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2988
Hernández Rodriguez, Tanja ; Pörtner, R. ; Frahm, Björn: Considerations for cell passaging in cell culture seed trains, 2015
ELSA
2013 | Konferenzband - Beitrag | ELSA-ID: 2817 |

Hernández Rodriguez, Tanja ; Pörtner, Ralf ; Frahm, Björn: Seed train optimization for suspension cell culture. Bd. 7 : BioMed Central , 2013
ELSA
| DOI
| Download (ext.)
2013 | Konferenz - Poster | ELSA-ID: 2983
Hernández Rodriguez, Tanja ; Pörtner, R. ; Frahm, Björn: Seed train optimization for suspension cell culture, 2013
ELSA