55 Publikationen

Alle markieren

[55]
2023 | Konferenz - Poster | ELSA-ID: 9574
Ramm, S., Hernández Rodriguez, T., Frahm, B., & Pein-Hackelbusch, M. (2023). Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression. BioProcessingDays 2023, Recklinghausen.
ELSA
 
[54]
2023 | Konferenz - Vortrag | ELSA-ID: 10133
Ramm, S., Hernández Rodriguez, T., Frahm, B., & Pein-Hackelbusch, M. (2023). Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. In IEEE International Conference on Industrial Informatics, INDIN ’23. IEEE International Conference on Industrial Informatics, INDIN ’23, Lemgo.
ELSA
 
[53]
2023 | Konferenz - Poster | ELSA-ID: 10201
Hernández Rodriguez, T., Ramm, S., Lange-Hegermann, M., & Frahm, B. (2023). A systematic, model-based workflow for risk-based decision making in upstream development. BioProcessingDays 2023, Recklinghausen, Germany.
ELSA
 
[52]
2023 | Konferenzband - Beitrag | ELSA-ID: 10788
Ramm, S., Hernández Rodriguez, T., Frahm, B., & Pein-Hackelbusch, M. (2023). Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. In 2023 IEEE 21st International Conference on Industrial Informatics (INDIN) (pp. 1–6). IEEE. https://doi.org/10.1109/INDIN51400.2023.10218012
ELSA | DOI
 
[51]
2022 | Konferenz - Poster | ELSA-ID: 7932
Hernández Rodriguez, T., Ramm, S., Lange-Hegermann, M., & Frahm, B. (2022). A systematic, model-based workflow for risk-based decision making in upstream development. 5th annual Bioprocessing Summit Europe, Barcelona, Spain.
ELSA
 
[50]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7976
Gassenmeier, V., Deppe, S., Hernández Rodriguez, T., Kuhfuß, F., Moser, A., Hass, V. C., Kuchemüller, K. B., Pörtner, R., Möller, J., Ifrim, G. A., & Frahm, B. (2022). Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. Current Research in Biotechnology, 4, 102–119. https://doi.org/10.1016/j.crbiot.2022.01.005
ELSA | DOI
 
[49]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7977
Kuhfuß, F., Gassenmeier, V., Deppe, S., Ifrim, G. A., Hernández Rodriguez, T., & Frahm, B. (2022). View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. Bioprocess and Biosystems Engineering, 45, 15–30. https://doi.org/10.1007/s00449-021-02627-2
ELSA | DOI
 
[48]
2022 | Sammelwerk - Beitrag | ELSA-ID: 10193
Hernández Rodriguez, T., Sekulic, A., Lange-Hegermann, M., & Frahm, B. (2022). Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In R. Pörtner & J. Möller (Eds.), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing: Vol. special issue (pp. 21–48). MDPI. https://doi.org/10.3390/pr10050883
ELSA | DOI
 
[47]
2022 | Konferenz - Vortrag | ELSA-ID: 10197
Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2022). Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture. In ACHEMA 2022. ACHEMA 2022, Frankfurt am Main, Germany.
ELSA
 
[46]
2022 | Konferenz - Poster | ELSA-ID: 10198
Hernández Rodriguez, T., Pörtner, R., Lange-Hegermann, M., Wurm, F. M., & Frahm, B. (2022). A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion. 27th Meeting of the European Society for Animal Cell Technology (ESACT): Advanced Cell Technologies: Making Protein, Cell, and Gene Therapies a Reality, Lisbon, Portugal .
ELSA
 
[45]
2021 | Konferenz - Vortrag | ELSA-ID: 7927
Hernández Rodriguez, T., & Frahm, B. (2021). Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction. International Week “Digitalization and Sustainability in Higher Education,” SeAMK, Seinäjoki, Finnland.
ELSA
 
[44]
2021 | Konferenz - Poster | ELSA-ID: 7931
Moser, A., Möller, J., Kuchemüller, K. B., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., … Hass, V. C. (2021). Model-assisted Design of Experiments - Concept, Software and Applications. Presented at the 24th International Congress of Chemical and Process Engineering, CHISA 2021, as a web conference, Prague, Czech Republic.
ELSA
 
[43]
2021 | Sammelwerk - Beitrag | ELSA-ID: 7983
Hernández Rodriguez, T., Morerod, S., Pörtner, R., Wurm, F. M., & Frahm, B. (2021). Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing: Vol. special issue (pp. 49–74). MDPI. https://doi.org/10.3390/pr9060964
ELSA | DOI
 
[42]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2021). Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering, 44(4), 793–808. https://doi.org/10.1007/s00449-020-02488-1
ELSA | DOI
 
[41]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7986
Moser, A., Kuchemüller, K. B., Deppe, S., Hernández Rodriguez, T., Frahm, B., Pörtner, R., Hass, V. C., & Möller, J. (2021). Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering, 44(4), 683–700. https://doi.org/10.1007/s00449-020-02478-3
ELSA | DOI
 
[40]
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
Hernández Rodriguez, T., & Frahm, B. (2021). Digital Seed Train Twins and Statistical Methods. In C. Herwig, R. Pörtner, & J. Möller (Eds.), Digital Twins Tools and Concepts for Smart Biomanufacturing (Vol. 176, pp. 97–131). Springer. https://doi.org/10.1007/10_2020_137
ELSA | DOI
 
[39]
2020 | Konferenz - Poster | ELSA-ID: 7929
Hernández Rodriguez, T., Deppe, S., Gassenmeier, V., Kuhfuß, F., Tölle, M., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. Presented at the 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020, als Web-Konferenz, Aachen, Germany.
ELSA
 
[38]
2020 | Konferenz - Poster | ELSA-ID: 7930
Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2020). Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. Presented at the 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020, als Web-Konferenz, Aachen, Germany.
ELSA
 
[37]
2020 | Konferenz - Vortrag | ELSA-ID: 7936
Hernández Rodriguez, T., Frahm, B., & Posch, C. (2020). Integration of prior knowledge and digital tools for uncertainty-based decision support. Presented at the 1st TRD (Technical Research & Development) Virtual Academia Strategic Roundtable, Sandoz, Austria.
ELSA
 
[36]
2020 | Konferenzband - Beitrag | ELSA-ID: 7937
Hernández Rodriguez, T., Deppe, S., Gassenmeier, V., Kuhfuß, F., Tölle, M., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 (Vol. No. 9, pp. 1225 – 1226). Wiley. https://doi.org/10.1002/cite.202055235
ELSA | DOI
 
[35]
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2020). Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 (Vol. No. 9, pp. 1241 – 1242). Wiley. https://doi.org/10.1002/cite.202055234
ELSA | DOI
 
[34]
2020 | Konferenz - Poster | ELSA-ID: 3007
Kuhfuß, F., Tölle, M., Hernández Rodriguez, T., Gassenmeier, V., Deppe, S., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. Presented at the BioProcessingDays 2020, Recklinghausen, Germany.
ELSA
 
[33]
2020 | Konferenz - Poster | ELSA-ID: 3008
Deppe, S., Kuhfuß, F., Tölle, M., Hernández Rodriguez, T., Gassenmeier, V., Ifrim, G. A., … Frahm, B. (2020). Model-assisted Design of Experiments for algae cultivation. Presented at the BioProcessingDays 2020, Recklinghausen, Germany.
ELSA
 
[32]
2020 | Konferenz - Poster | ELSA-ID: 3009
Ifrim, G. A., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., & Frahm, B. (2020). Modeling of microalgae in an air-lift photobioreactor for biomass production. Presented at the BioProcessingDays 2020, Recklinghausen, Germany.
ELSA
 
[31]
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, Claus , Pörtner, R., & Frahm, B. (2020). Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach. BMC Proceedings (Vol. 14, p. P408). Copenhagen, Denmark.: BioMed Central. https://doi.org/10.1186/s12919-020-00188-y
ELSA | Dateien verfügbar | DOI
 
[30]
2019 | Konferenz - Poster | ELSA-ID: 3000
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the BioProcessingDays 2019, Recklinghausen, Germany.
ELSA
 
[29]
2019 | Konferenz - Poster | ELSA-ID: 3001
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the 26th Meeting of the European Society for Animal Cell Technology (ESACT): Cell culture technologies: bridging academia and industry to provide solutions for patients, Copenhagen, Denmark.
ELSA
 
[28]
2019 | Konferenz - Poster | ELSA-ID: 3002
Möller, J., Kuchemüller, K. B., Hernández Rodriguez, T., Deppe, S., Ifrim, G. A., Moser, A., … Pörtner, R. (2019). Model-Assisted Design of Experiments – Software Toolbox. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[27]
2019 | Konferenz - Poster | ELSA-ID: 3003
Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., Tölle, M., Kuhfuß, F., Möller, J., … Frahm, B. (2019). Model-assisted Design of Experiments for algae cultivation. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[26]
2019 | Konferenz - Poster | ELSA-ID: 3004
Ifrim, G. A., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., & Frahm, B. (2019). Modeling of microalgae in an air-lift photobioreactor for biomass production. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[25]
2019 | Konferenz - Poster | ELSA-ID: 3005
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[24]
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 | OA
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, C., Pörtner, R., & Frahm, B. (2019). Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method. Biotechnology and Bioengineering, 116(11), 2944–2959. https://doi.org/10.1002/bit.27125
ELSA | DOI | Download (ext.)
 
[23]
2019 | Konferenz - Vortrag | ELSA-ID: 2956
Möller, J., Müller, J., Hernández Rodriguez, T., Kuchemüller, K. B., Arndt, L., Frahm, B., … Pörtner, R. (2019). Workflow for model-assisted design and scale-up of biopharmaceutical production processes. Presented at the BioTech 2019 - Biopharmaceutical Manufacturing and Single-Use Technologies: Process intensification and continuous bioprocessing with single-use devices, Wädenswil, Switzerland.
ELSA
 
[22]
2019 | Konferenz - Vortrag | ELSA-ID: 2957
Möller, J., Kuchemüller, K. B., Moser, A., Hass, V. C., Hernández Rodriguez, T., Deppe, S., … Pörtner, R. (2019). Model-Assisted Design of Experiments. Presented at the 5th European Congress of Applied Biotechnology, Florence, Italy.
ELSA
 
[21]
2018 | Konferenz - Vortrag | ELSA-ID: 7935
Hernández Rodriguez, T., Frahm, B., Posch, C., Schmutzhard, J., & Stettner, J. (2018). A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization. Presented at the Sandoz, Kundl, Austria.
ELSA
 
[20]
2018 | Konferenz - Poster | ELSA-ID: 2997
Möller, J., Kuchemüller, K. B., Freiberger, F., Levermann, P., Hernández Rodriguez, T., Frahm, B., … Pörtner, R. (2018). Model-Assisted Design and Optimization of Process Strategies. Presented at the BioProcessingDays 2018, Recklinghausen, Germany.
ELSA
 
[19]
2018 | Konferenz - Poster | ELSA-ID: 2999
Hernández Rodriguez, T., Möller, J., Kuchemüller, K. B., Freiberger, F., Levermann, P., Hass, V. C., … Pörtner, R. (2018). Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses. Presented at the 5th BioProScale Symposium: Innovative scale up and scale down for bioprocess intensification, Berlin, Germany.
ELSA
 
[18]
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 | OA
Möller, J., Kuchemüller, K. B., Hernández Rodriguez, T., Frahm, B., Hass, V. C., & Pörtner, R. (2018). Model-Assisted Design of Process Strategies for Cell Culture Processes. American Pharmaceutical Review, 3, 39–41.
ELSA | Download (ext.)
 
[17]
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
Hernández Rodriguez, T., Krull, S., Hass, V. C., Möller, J., Pörtner, R., & Frahm, B. (2018). Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. BMC Proceedings (Vol. 112, p. P175). Lausanne, Switzerland: BioMed Central. https://doi.org/10.1186/s12919-018-0097-x
ELSA | Dateien verfügbar | DOI
 
[16]
2017 | Konferenz - Poster | ELSA-ID: 2994
Hernández Rodriguez, T., Koopmann, K. S., Pörtner, R., & Frahm, B. (2017). Influence of parameter accuracies in cell culture seed train simulations. Presented at the BioProcessingDays 2017, Recklinghausen, Germany.
ELSA
 
[15]
2017 | Konferenz - Poster | ELSA-ID: 2995
Hernández Rodriguez, T., Krull, S., Hass, V. C., Möller, J., Pörtner, R., & Frahm, B. (2017). Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. Presented at the 25th Meeting of the European Society for Animal Cell Technology (ESACT): Cell technologies for innovative therapies, Lausanne, Switzerland.
ELSA
 
[14]
2017 | Konferenz - Poster | ELSA-ID: 2996
Hernández Rodriguez, T., Krull, S., Hass, V. C., Pörtner, R., & Frahm, B. (2017). Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. Presented at the DECHEMA Himmelfahrtstagung “Models for Developing and Optimising Biotech Production,” Neu-Ulm, Germany.
ELSA
 
[13]
2017 | Konferenz - Vortrag | ELSA-ID: 2920
Hernández Rodriguez, T., Kern, S., Platas Barradas, O., Pörtner, R., & Frahm, B. (2017). Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. Presented at the 3. Lippischer Automatisierungstreff der Produktions- und Werkstofftechnik (LAT/PWT), Lemgo, Germany.
ELSA
 
[12]
2017 | Konferenz - Vortrag | ELSA-ID: 2921
Pörtner, R., Möller, J., Hernández Rodriguez, T., Frahm, B., & Hass, V. C. (2017). Model-assisted design and optimization of biotechnological processes. Presented at the DECHEMA Himmelfahrtstagung “Models for Developing and Optimising Biotech Production, Neu-Ulm, Germany.
ELSA
 
[11]
2017 | Konferenz - Vortrag | ELSA-ID: 2950
Hernández Rodriguez, T., Koopmann, K. S., Klaes, J., Kern, S., Platas Barradas, O., Pörtner, R., & Frahm, B. (2017). Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. Presented at the MATLAB EXPO, Track “Optimierungsaufgaben in der Praxis,” Munic, Germany.
ELSA
 
[10]
2016 | Konferenz - Poster | ELSA-ID: 2992
Hernández Rodriguez, T., Vörtler, S., Kern, S., Platas Barradas, O., Pörtner, R., & Frahm, B. (2016). A software tool for biopharmaceutical seed train design and optimization. Presented at the BioProcessingDays 2016, Recklinghausen, Germany.
ELSA
 
[9]
2016 | Konferenz - Poster | ELSA-ID: 2993
Koopmann, K. S., Hernández Rodriguez, T., Vörtler, S., Beshay, U., Möller, J., Pörtner, R., & Frahm, B. (2016). Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies. Presented at the DECHEMA Himmelfahrtstagung “New Frontiers for Biotech-Processes,” Koblenz, Germany.
ELSA
 
[8]
2015 | Konferenz - Poster | ELSA-ID: 2985
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). Considerations for cell passaging in cell culture seed trains. Presented at the DECHEMA Himmelfahrtstagung “Scale-up and scale-down of bioprocesses,” Hamburg, Germany.
ELSA
 
[7]
2015 | Konferenz - Poster | ELSA-ID: 2987
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). A software tool for biopharmaceutical seed train design and optimization. Presented at the MATLAB EXPO, Munic, Germany.
ELSA
 
[6]
2015 | Konferenz - Poster | ELSA-ID: 2988
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). Considerations for cell passaging in cell culture seed trains. Presented at the 24th Meeting of the European Society for Animal Cell Technology (ESACT): C2P2: Cells, Culture, Patients, Products, Barcelona, Spain.
ELSA
 
[5]
2015 | Konferenzband - Beitrag | ELSA-ID: 2819 | OA
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). Considerations for cell passaging in cell culture seed trains. BMC proceedings / BioMed Central (Vol. 9). BioMed Central. https://doi.org/10.1186/1753-6561-9-s9-p43
ELSA | DOI | Download (ext.)
 
[4]
2015 | Konferenz - Vortrag | ELSA-ID: 2917
Frahm, B., Pörtner, R., Kern, S., & Hernández Rodriguez, T. (2015). Seed train design and optimization for animal cell suspension culture. Presented at the ACHEMA 2015, Frankfurt am Main, Germany.
ELSA | Dateien verfügbar
 
[3]
2015 | Konferenz - Vortrag | ELSA-ID: 2919
Frahm, B., Hernández Rodriguez, T., Kern, S., Koopmann, K. S., Beshay, U., Platas-Barradas, O., & Pörtner, R. (2015). Seed train design and optimization for animal cell suspension culture. Presented at the Max-Planck-Institut für Dynamik komplexer technischer Systeme, Magdeburg, Germany.
ELSA
 
[2]
2013 | Konferenz - Poster | ELSA-ID: 2983
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2013). Seed train optimization for suspension cell culture. Presented at the 23rd Meeting of the European Society for Animal Cell Technology (ESACT): Better Cells for Better Health, Lille, France.
ELSA
 
[1]
2013 | Konferenzband - Beitrag | ELSA-ID: 2817 | OA
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2013). Seed train optimization for suspension cell culture. BMC proceedings / BioMed Central (Vol. 7). BioMed Central . https://doi.org/10.1186/1753-6561-7-s6-p9
ELSA | DOI | Download (ext.)
 

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55 Publikationen

Alle markieren

[55]
2023 | Konferenz - Poster | ELSA-ID: 9574
Ramm, S., Hernández Rodriguez, T., Frahm, B., & Pein-Hackelbusch, M. (2023). Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression. BioProcessingDays 2023, Recklinghausen.
ELSA
 
[54]
2023 | Konferenz - Vortrag | ELSA-ID: 10133
Ramm, S., Hernández Rodriguez, T., Frahm, B., & Pein-Hackelbusch, M. (2023). Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. In IEEE International Conference on Industrial Informatics, INDIN ’23. IEEE International Conference on Industrial Informatics, INDIN ’23, Lemgo.
ELSA
 
[53]
2023 | Konferenz - Poster | ELSA-ID: 10201
Hernández Rodriguez, T., Ramm, S., Lange-Hegermann, M., & Frahm, B. (2023). A systematic, model-based workflow for risk-based decision making in upstream development. BioProcessingDays 2023, Recklinghausen, Germany.
ELSA
 
[52]
2023 | Konferenzband - Beitrag | ELSA-ID: 10788
Ramm, S., Hernández Rodriguez, T., Frahm, B., & Pein-Hackelbusch, M. (2023). Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. In 2023 IEEE 21st International Conference on Industrial Informatics (INDIN) (pp. 1–6). IEEE. https://doi.org/10.1109/INDIN51400.2023.10218012
ELSA | DOI
 
[51]
2022 | Konferenz - Poster | ELSA-ID: 7932
Hernández Rodriguez, T., Ramm, S., Lange-Hegermann, M., & Frahm, B. (2022). A systematic, model-based workflow for risk-based decision making in upstream development. 5th annual Bioprocessing Summit Europe, Barcelona, Spain.
ELSA
 
[50]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7976
Gassenmeier, V., Deppe, S., Hernández Rodriguez, T., Kuhfuß, F., Moser, A., Hass, V. C., Kuchemüller, K. B., Pörtner, R., Möller, J., Ifrim, G. A., & Frahm, B. (2022). Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. Current Research in Biotechnology, 4, 102–119. https://doi.org/10.1016/j.crbiot.2022.01.005
ELSA | DOI
 
[49]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7977
Kuhfuß, F., Gassenmeier, V., Deppe, S., Ifrim, G. A., Hernández Rodriguez, T., & Frahm, B. (2022). View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. Bioprocess and Biosystems Engineering, 45, 15–30. https://doi.org/10.1007/s00449-021-02627-2
ELSA | DOI
 
[48]
2022 | Sammelwerk - Beitrag | ELSA-ID: 10193
Hernández Rodriguez, T., Sekulic, A., Lange-Hegermann, M., & Frahm, B. (2022). Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In R. Pörtner & J. Möller (Eds.), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing: Vol. special issue (pp. 21–48). MDPI. https://doi.org/10.3390/pr10050883
ELSA | DOI
 
[47]
2022 | Konferenz - Vortrag | ELSA-ID: 10197
Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2022). Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture. In ACHEMA 2022. ACHEMA 2022, Frankfurt am Main, Germany.
ELSA
 
[46]
2022 | Konferenz - Poster | ELSA-ID: 10198
Hernández Rodriguez, T., Pörtner, R., Lange-Hegermann, M., Wurm, F. M., & Frahm, B. (2022). A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion. 27th Meeting of the European Society for Animal Cell Technology (ESACT): Advanced Cell Technologies: Making Protein, Cell, and Gene Therapies a Reality, Lisbon, Portugal .
ELSA
 
[45]
2021 | Konferenz - Vortrag | ELSA-ID: 7927
Hernández Rodriguez, T., & Frahm, B. (2021). Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction. International Week “Digitalization and Sustainability in Higher Education,” SeAMK, Seinäjoki, Finnland.
ELSA
 
[44]
2021 | Konferenz - Poster | ELSA-ID: 7931
Moser, A., Möller, J., Kuchemüller, K. B., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., … Hass, V. C. (2021). Model-assisted Design of Experiments - Concept, Software and Applications. Presented at the 24th International Congress of Chemical and Process Engineering, CHISA 2021, as a web conference, Prague, Czech Republic.
ELSA
 
[43]
2021 | Sammelwerk - Beitrag | ELSA-ID: 7983
Hernández Rodriguez, T., Morerod, S., Pörtner, R., Wurm, F. M., & Frahm, B. (2021). Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing: Vol. special issue (pp. 49–74). MDPI. https://doi.org/10.3390/pr9060964
ELSA | DOI
 
[42]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2021). Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering, 44(4), 793–808. https://doi.org/10.1007/s00449-020-02488-1
ELSA | DOI
 
[41]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7986
Moser, A., Kuchemüller, K. B., Deppe, S., Hernández Rodriguez, T., Frahm, B., Pörtner, R., Hass, V. C., & Möller, J. (2021). Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering, 44(4), 683–700. https://doi.org/10.1007/s00449-020-02478-3
ELSA | DOI
 
[40]
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
Hernández Rodriguez, T., & Frahm, B. (2021). Digital Seed Train Twins and Statistical Methods. In C. Herwig, R. Pörtner, & J. Möller (Eds.), Digital Twins Tools and Concepts for Smart Biomanufacturing (Vol. 176, pp. 97–131). Springer. https://doi.org/10.1007/10_2020_137
ELSA | DOI
 
[39]
2020 | Konferenz - Poster | ELSA-ID: 7929
Hernández Rodriguez, T., Deppe, S., Gassenmeier, V., Kuhfuß, F., Tölle, M., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. Presented at the 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020, als Web-Konferenz, Aachen, Germany.
ELSA
 
[38]
2020 | Konferenz - Poster | ELSA-ID: 7930
Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2020). Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. Presented at the 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020, als Web-Konferenz, Aachen, Germany.
ELSA
 
[37]
2020 | Konferenz - Vortrag | ELSA-ID: 7936
Hernández Rodriguez, T., Frahm, B., & Posch, C. (2020). Integration of prior knowledge and digital tools for uncertainty-based decision support. Presented at the 1st TRD (Technical Research & Development) Virtual Academia Strategic Roundtable, Sandoz, Austria.
ELSA
 
[36]
2020 | Konferenzband - Beitrag | ELSA-ID: 7937
Hernández Rodriguez, T., Deppe, S., Gassenmeier, V., Kuhfuß, F., Tölle, M., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 (Vol. No. 9, pp. 1225 – 1226). Wiley. https://doi.org/10.1002/cite.202055235
ELSA | DOI
 
[35]
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2020). Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 (Vol. No. 9, pp. 1241 – 1242). Wiley. https://doi.org/10.1002/cite.202055234
ELSA | DOI
 
[34]
2020 | Konferenz - Poster | ELSA-ID: 3007
Kuhfuß, F., Tölle, M., Hernández Rodriguez, T., Gassenmeier, V., Deppe, S., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. Presented at the BioProcessingDays 2020, Recklinghausen, Germany.
ELSA
 
[33]
2020 | Konferenz - Poster | ELSA-ID: 3008
Deppe, S., Kuhfuß, F., Tölle, M., Hernández Rodriguez, T., Gassenmeier, V., Ifrim, G. A., … Frahm, B. (2020). Model-assisted Design of Experiments for algae cultivation. Presented at the BioProcessingDays 2020, Recklinghausen, Germany.
ELSA
 
[32]
2020 | Konferenz - Poster | ELSA-ID: 3009
Ifrim, G. A., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., & Frahm, B. (2020). Modeling of microalgae in an air-lift photobioreactor for biomass production. Presented at the BioProcessingDays 2020, Recklinghausen, Germany.
ELSA
 
[31]
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, Claus , Pörtner, R., & Frahm, B. (2020). Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach. BMC Proceedings (Vol. 14, p. P408). Copenhagen, Denmark.: BioMed Central. https://doi.org/10.1186/s12919-020-00188-y
ELSA | Dateien verfügbar | DOI
 
[30]
2019 | Konferenz - Poster | ELSA-ID: 3000
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the BioProcessingDays 2019, Recklinghausen, Germany.
ELSA
 
[29]
2019 | Konferenz - Poster | ELSA-ID: 3001
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the 26th Meeting of the European Society for Animal Cell Technology (ESACT): Cell culture technologies: bridging academia and industry to provide solutions for patients, Copenhagen, Denmark.
ELSA
 
[28]
2019 | Konferenz - Poster | ELSA-ID: 3002
Möller, J., Kuchemüller, K. B., Hernández Rodriguez, T., Deppe, S., Ifrim, G. A., Moser, A., … Pörtner, R. (2019). Model-Assisted Design of Experiments – Software Toolbox. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[27]
2019 | Konferenz - Poster | ELSA-ID: 3003
Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., Tölle, M., Kuhfuß, F., Möller, J., … Frahm, B. (2019). Model-assisted Design of Experiments for algae cultivation. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[26]
2019 | Konferenz - Poster | ELSA-ID: 3004
Ifrim, G. A., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., & Frahm, B. (2019). Modeling of microalgae in an air-lift photobioreactor for biomass production. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[25]
2019 | Konferenz - Poster | ELSA-ID: 3005
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[24]
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 | OA
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, C., Pörtner, R., & Frahm, B. (2019). Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method. Biotechnology and Bioengineering, 116(11), 2944–2959. https://doi.org/10.1002/bit.27125
ELSA | DOI | Download (ext.)
 
[23]
2019 | Konferenz - Vortrag | ELSA-ID: 2956
Möller, J., Müller, J., Hernández Rodriguez, T., Kuchemüller, K. B., Arndt, L., Frahm, B., … Pörtner, R. (2019). Workflow for model-assisted design and scale-up of biopharmaceutical production processes. Presented at the BioTech 2019 - Biopharmaceutical Manufacturing and Single-Use Technologies: Process intensification and continuous bioprocessing with single-use devices, Wädenswil, Switzerland.
ELSA
 
[22]
2019 | Konferenz - Vortrag | ELSA-ID: 2957
Möller, J., Kuchemüller, K. B., Moser, A., Hass, V. C., Hernández Rodriguez, T., Deppe, S., … Pörtner, R. (2019). Model-Assisted Design of Experiments. Presented at the 5th European Congress of Applied Biotechnology, Florence, Italy.
ELSA
 
[21]
2018 | Konferenz - Vortrag | ELSA-ID: 7935
Hernández Rodriguez, T., Frahm, B., Posch, C., Schmutzhard, J., & Stettner, J. (2018). A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization. Presented at the Sandoz, Kundl, Austria.
ELSA
 
[20]
2018 | Konferenz - Poster | ELSA-ID: 2997
Möller, J., Kuchemüller, K. B., Freiberger, F., Levermann, P., Hernández Rodriguez, T., Frahm, B., … Pörtner, R. (2018). Model-Assisted Design and Optimization of Process Strategies. Presented at the BioProcessingDays 2018, Recklinghausen, Germany.
ELSA
 
[19]
2018 | Konferenz - Poster | ELSA-ID: 2999
Hernández Rodriguez, T., Möller, J., Kuchemüller, K. B., Freiberger, F., Levermann, P., Hass, V. C., … Pörtner, R. (2018). Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses. Presented at the 5th BioProScale Symposium: Innovative scale up and scale down for bioprocess intensification, Berlin, Germany.
ELSA
 
[18]
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 | OA
Möller, J., Kuchemüller, K. B., Hernández Rodriguez, T., Frahm, B., Hass, V. C., & Pörtner, R. (2018). Model-Assisted Design of Process Strategies for Cell Culture Processes. American Pharmaceutical Review, 3, 39–41.
ELSA | Download (ext.)
 
[17]
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
Hernández Rodriguez, T., Krull, S., Hass, V. C., Möller, J., Pörtner, R., & Frahm, B. (2018). Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. BMC Proceedings (Vol. 112, p. P175). Lausanne, Switzerland: BioMed Central. https://doi.org/10.1186/s12919-018-0097-x
ELSA | Dateien verfügbar | DOI
 
[16]
2017 | Konferenz - Poster | ELSA-ID: 2994
Hernández Rodriguez, T., Koopmann, K. S., Pörtner, R., & Frahm, B. (2017). Influence of parameter accuracies in cell culture seed train simulations. Presented at the BioProcessingDays 2017, Recklinghausen, Germany.
ELSA
 
[15]
2017 | Konferenz - Poster | ELSA-ID: 2995
Hernández Rodriguez, T., Krull, S., Hass, V. C., Möller, J., Pörtner, R., & Frahm, B. (2017). Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. Presented at the 25th Meeting of the European Society for Animal Cell Technology (ESACT): Cell technologies for innovative therapies, Lausanne, Switzerland.
ELSA
 
[14]
2017 | Konferenz - Poster | ELSA-ID: 2996
Hernández Rodriguez, T., Krull, S., Hass, V. C., Pörtner, R., & Frahm, B. (2017). Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. Presented at the DECHEMA Himmelfahrtstagung “Models for Developing and Optimising Biotech Production,” Neu-Ulm, Germany.
ELSA
 
[13]
2017 | Konferenz - Vortrag | ELSA-ID: 2920
Hernández Rodriguez, T., Kern, S., Platas Barradas, O., Pörtner, R., & Frahm, B. (2017). Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. Presented at the 3. Lippischer Automatisierungstreff der Produktions- und Werkstofftechnik (LAT/PWT), Lemgo, Germany.
ELSA
 
[12]
2017 | Konferenz - Vortrag | ELSA-ID: 2921
Pörtner, R., Möller, J., Hernández Rodriguez, T., Frahm, B., & Hass, V. C. (2017). Model-assisted design and optimization of biotechnological processes. Presented at the DECHEMA Himmelfahrtstagung “Models for Developing and Optimising Biotech Production, Neu-Ulm, Germany.
ELSA
 
[11]
2017 | Konferenz - Vortrag | ELSA-ID: 2950
Hernández Rodriguez, T., Koopmann, K. S., Klaes, J., Kern, S., Platas Barradas, O., Pörtner, R., & Frahm, B. (2017). Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. Presented at the MATLAB EXPO, Track “Optimierungsaufgaben in der Praxis,” Munic, Germany.
ELSA
 
[10]
2016 | Konferenz - Poster | ELSA-ID: 2992
Hernández Rodriguez, T., Vörtler, S., Kern, S., Platas Barradas, O., Pörtner, R., & Frahm, B. (2016). A software tool for biopharmaceutical seed train design and optimization. Presented at the BioProcessingDays 2016, Recklinghausen, Germany.
ELSA
 
[9]
2016 | Konferenz - Poster | ELSA-ID: 2993
Koopmann, K. S., Hernández Rodriguez, T., Vörtler, S., Beshay, U., Möller, J., Pörtner, R., & Frahm, B. (2016). Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies. Presented at the DECHEMA Himmelfahrtstagung “New Frontiers for Biotech-Processes,” Koblenz, Germany.
ELSA
 
[8]
2015 | Konferenz - Poster | ELSA-ID: 2985
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). Considerations for cell passaging in cell culture seed trains. Presented at the DECHEMA Himmelfahrtstagung “Scale-up and scale-down of bioprocesses,” Hamburg, Germany.
ELSA
 
[7]
2015 | Konferenz - Poster | ELSA-ID: 2987
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). A software tool for biopharmaceutical seed train design and optimization. Presented at the MATLAB EXPO, Munic, Germany.
ELSA
 
[6]
2015 | Konferenz - Poster | ELSA-ID: 2988
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). Considerations for cell passaging in cell culture seed trains. Presented at the 24th Meeting of the European Society for Animal Cell Technology (ESACT): C2P2: Cells, Culture, Patients, Products, Barcelona, Spain.
ELSA
 
[5]
2015 | Konferenzband - Beitrag | ELSA-ID: 2819 | OA
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). Considerations for cell passaging in cell culture seed trains. BMC proceedings / BioMed Central (Vol. 9). BioMed Central. https://doi.org/10.1186/1753-6561-9-s9-p43
ELSA | DOI | Download (ext.)
 
[4]
2015 | Konferenz - Vortrag | ELSA-ID: 2917
Frahm, B., Pörtner, R., Kern, S., & Hernández Rodriguez, T. (2015). Seed train design and optimization for animal cell suspension culture. Presented at the ACHEMA 2015, Frankfurt am Main, Germany.
ELSA | Dateien verfügbar
 
[3]
2015 | Konferenz - Vortrag | ELSA-ID: 2919
Frahm, B., Hernández Rodriguez, T., Kern, S., Koopmann, K. S., Beshay, U., Platas-Barradas, O., & Pörtner, R. (2015). Seed train design and optimization for animal cell suspension culture. Presented at the Max-Planck-Institut für Dynamik komplexer technischer Systeme, Magdeburg, Germany.
ELSA
 
[2]
2013 | Konferenz - Poster | ELSA-ID: 2983
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2013). Seed train optimization for suspension cell culture. Presented at the 23rd Meeting of the European Society for Animal Cell Technology (ESACT): Better Cells for Better Health, Lille, France.
ELSA
 
[1]
2013 | Konferenzband - Beitrag | ELSA-ID: 2817 | OA
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2013). Seed train optimization for suspension cell culture. BMC proceedings / BioMed Central (Vol. 7). BioMed Central . https://doi.org/10.1186/1753-6561-7-s6-p9
ELSA | DOI | Download (ext.)
 

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