Tanja Hernández Rodriguez

tanja.hernandez@th-owl.de
ID
52466

61 Publikationen

Alle markieren

[61]
2024 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 12402
P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator, Chemie Ingenieur Technik. 96 (2024) 528–534.
ELSA | DOI | WoS
 
[60]
2023 | Konferenz - Poster | ELSA-ID: 11381
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development, DECHEMA e.V., n.d.
ELSA
 
[59]
2023 | Konferenz - Poster | ELSA-ID: 11382 | OA
V. Gassenmeier, F. Kuhfuß, S. Deppe, G. Ifrim, T. Hernández Rodriguez, B. Frahm, View on a mechanistic model of Chlorella vulgaris in shake flasks, n.d.
ELSA | Download (ext.)
 
[58]
2023 | Konferenz - Vortrag | ELSA-ID: 11383
T. Hernández Rodriguez, C. Posch, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture, DECHEMA e.V., 2023.
ELSA
 
[57]
2023 | Konferenz - Poster | ELSA-ID: 11487 | OA
S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression , DECHEMA e.V., n.d.
ELSA | Download (ext.)
 
[56]
2023 | Konferenz - Poster | ELSA-ID: 10201 | OA
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development, 2023.
ELSA | Download (ext.)
 
[55]
2023 | Konferenzband - Beitrag | ELSA-ID: 10788 | OA
S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, IEEE, [Piscataway, NJ], 2023.
ELSA | DOI | Download (ext.)
 
[54]
2023 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11385
P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations, Chemie Ingenieur Technik. 95 (2023) 1960–1969.
ELSA | DOI | WoS
 
[53]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11377
T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design, Processes. 10 (2022).
ELSA | DOI
 
[52]
2022 | Konferenz - Poster | ELSA-ID: 7932
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development, n.d.
ELSA
 
[51]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7976
V. Gassenmeier, S. Deppe, T. Hernández Rodriguez, F. Kuhfuß, A. Moser, V.C. Hass, K.B. Kuchemüller, R. Pörtner, J. Möller, G.A. Ifrim, B. Frahm, Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology, Current Research in Biotechnology. 4 (2022) 102–119.
ELSA | DOI
 
[50]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7977
F. Kuhfuß, V. Gassenmeier, S. Deppe, G.A. Ifrim, T. Hernández Rodriguez, B. Frahm, View on a mechanistic model of Chlorella vulgaris in incubated shake flasks, Bioprocess and Biosystems Engineering. 45 (2022) 15–30.
ELSA | DOI
 
[49]
2022 | Sammelwerk - Beitrag | ELSA-ID: 10193
T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design, in: R. Pörtner, J. Möller (Eds.), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2022: pp. 21–48.
ELSA | DOI
 
[48]
2022 | Konferenz - Vortrag | ELSA-ID: 10197
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture, 2022.
ELSA
 
[47]
2022 | Konferenz - Poster | ELSA-ID: 10198
T. Hernández Rodriguez, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion, n.d.
ELSA
 
[46]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11376
T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study, Processes. 9 (2021).
ELSA | DOI
 
[45]
2021 | Konferenz - Vortrag | ELSA-ID: 7927
T. Hernández Rodriguez, B. Frahm, Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction, 2021.
ELSA
 
[44]
2021 | Konferenz - Poster | ELSA-ID: 7931
A. Moser, J. Möller, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, B. Frahm, R. Pörtner, V.C. Hass, Model-assisted Design of Experiments - Concept, Software and Applications, 2021.
ELSA
 
[43]
2021 | Sammelwerk - Beitrag | ELSA-ID: 7983
T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study, in: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2021: pp. 49–74.
ELSA | DOI
 
[42]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train, Bioprocess and Biosystems Engineering. 44 (2021) 793–808.
ELSA | DOI
 
[41]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7986
A. Moser, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, B. Frahm, R. Pörtner, V.C. Hass, J. Möller, Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses, Bioprocess and Biosystems Engineering. 44 (2021) 683–700.
ELSA | DOI
 
[40]
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
T. Hernández Rodriguez, B. Frahm, Digital Seed Train Twins and Statistical Methods, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digital Twins Tools and Concepts for Smart Biomanufacturing, Springer, Berlin, Heidelberg, 2021: pp. 97–131.
ELSA | DOI
 
[39]
2020 | Konferenz - Poster | ELSA-ID: 7929
T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration, 2020.
ELSA
 
[38]
2020 | Konferenz - Poster | ELSA-ID: 7930
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes, 2020.
ELSA
 
[37]
2020 | Konferenz - Vortrag | ELSA-ID: 7936
T. Hernández Rodriguez, B. Frahm, C. Posch, Integration of prior knowledge and digital tools for uncertainty-based decision support, 2020.
ELSA
 
[36]
2020 | Konferenzband - Beitrag | ELSA-ID: 7937
T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration, Wiley, 2020.
ELSA | DOI
 
[35]
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes, Wiley, 2020.
ELSA | DOI
 
[34]
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, Claus Weihs, R. Pörtner, B. Frahm, Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach, BioMed Central, 2020.
ELSA | Dateien verfügbar | DOI
 
[33]
2020 | Konferenz - Poster | ELSA-ID: 3007
F. Kuhfuß, M. Tölle, T. Hernández Rodriguez, V. Gassenmeier, S. Deppe, G.A. Ifrim, B. Frahm, Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration, 2020.
ELSA
 
[32]
2020 | Konferenz - Poster | ELSA-ID: 3008
S. Deppe, F. Kuhfuß, M. Tölle, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, J. Möller, R. Pörtner, A. Moser, V.C. Hass, B. Frahm, Model-assisted Design of Experiments for algae cultivation, 2020.
ELSA
 
[31]
2020 | Konferenz - Poster | ELSA-ID: 3009
G.A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, B. Frahm, Modeling of microalgae in an air-lift photobioreactor for biomass production, 2020.
ELSA
 
[30]
2019 | Konferenz - Vortrag | ELSA-ID: 2956
J. Möller, J. Müller, T. Hernández Rodriguez, K.B. Kuchemüller, L. Arndt, B. Frahm, R. Eibl, D. Eibl, R. Pörtner, Workflow for model-assisted design and scale-up of biopharmaceutical production processes, 2019.
ELSA
 
[29]
2019 | Konferenz - Vortrag | ELSA-ID: 2957
J. Möller, K.B. Kuchemüller, A. Moser, V.C. Hass, T. Hernández Rodriguez, S. Deppe, B. Frahm, R. Pörtner, Model-Assisted Design of Experiments, 2019.
ELSA
 
[28]
2019 | Konferenz - Poster | ELSA-ID: 3000
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019.
ELSA
 
[27]
2019 | Konferenz - Poster | ELSA-ID: 3001
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019.
ELSA
 
[26]
2019 | Konferenz - Poster | ELSA-ID: 3002
J. Möller, K.B. Kuchemüller, T. Hernández Rodriguez, S. Deppe, G.A. Ifrim, A. Moser, V.C. Hass, B. Frahm, R. Pörtner, Model-Assisted Design of Experiments – Software Toolbox, 2019.
ELSA
 
[25]
2019 | Konferenz - Poster | ELSA-ID: 3003
S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, M. Tölle, F. Kuhfuß, J. Möller, K.B. Kuchemüller, R. Pörtner, A. Moser, V.C. Hass, G.A. Ifrim, B. Frahm, Model-assisted Design of Experiments for algae cultivation, 2019.
ELSA
 
[24]
2019 | Konferenz - Poster | ELSA-ID: 3004
G.A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, B. Frahm, Modeling of microalgae in an air-lift photobioreactor for biomass production, 2019.
ELSA
 
[23]
2019 | Konferenz - Poster | ELSA-ID: 3005
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019.
ELSA
 
[22]
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 | OA
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, C. Weihs, R. Pörtner, B. Frahm, Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method, Biotechnology and Bioengineering. 116 (2019) 2944–2959.
ELSA | DOI | Download (ext.)
 
[21]
2018 | Konferenz - Vortrag | ELSA-ID: 7935
T. Hernández Rodriguez, B. Frahm, C. Posch, J. Schmutzhard, J. Stettner, A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization, 2018.
ELSA
 
[20]
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
T. Hernández Rodriguez, S. Krull, V.C. Hass, J. Möller, R. Pörtner, B. Frahm, Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization, BioMed Central, 2018.
ELSA | Dateien verfügbar | DOI
 
[19]
2018 | Konferenz - Poster | ELSA-ID: 2997
J. Möller, K.B. Kuchemüller, F. Freiberger, P. Levermann, T. Hernández Rodriguez, B. Frahm, V.C. Hass, R. Pörtner, Model-Assisted Design and Optimization of Process Strategies, 2018.
ELSA
 
[18]
2018 | Konferenz - Poster | ELSA-ID: 2999
T. Hernández Rodriguez, J. Möller, K.B. Kuchemüller, F. Freiberger, P. Levermann, V.C. Hass, B. Frahm, R. Pörtner, Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses, 2018.
ELSA
 
[17]
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 | OA
J. Möller, K.B. Kuchemüller, T. Hernández Rodriguez, B. Frahm, V.C. Hass, R. Pörtner, Model-Assisted Design of Process Strategies for Cell Culture Processes, American Pharmaceutical Review. 3 (2018) 39–41.
ELSA | Download (ext.)
 
[16]
2017 | Konferenz - Vortrag | ELSA-ID: 2920
T. Hernández Rodriguez, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017.
ELSA
 
[15]
2017 | Konferenz - Vortrag | ELSA-ID: 2921
R. Pörtner, J. Möller, T. Hernández Rodriguez, B. Frahm, V.C. Hass, Model-assisted design and optimization of biotechnological processes, 2017.
ELSA
 
[14]
2017 | Konferenz - Vortrag | ELSA-ID: 2950
T. Hernández Rodriguez, K.S. Koopmann, J. Klaes, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017.
ELSA
 
[13]
2017 | Konferenz - Poster | ELSA-ID: 2994
T. Hernández Rodriguez, K.S. Koopmann, R. Pörtner, B. Frahm, Influence of parameter accuracies in cell culture seed train simulations, 2017.
ELSA
 
[12]
2017 | Konferenz - Poster | ELSA-ID: 2995
T. Hernández Rodriguez, S. Krull, V.C. Hass, J. Möller, R. Pörtner, B. Frahm, Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization, 2017.
ELSA
 
[11]
2017 | Konferenz - Poster | ELSA-ID: 2996
T. Hernández Rodriguez, S. Krull, V.C. Hass, R. Pörtner, B. Frahm, Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization, 2017.
ELSA
 
[10]
2016 | Konferenz - Poster | ELSA-ID: 2992
T. Hernández Rodriguez, S. Vörtler, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, A software tool for biopharmaceutical seed train design and optimization, 2016.
ELSA
 
[9]
2016 | Konferenz - Poster | ELSA-ID: 2993
K.S. Koopmann, T. Hernández Rodriguez, S. Vörtler, U. Beshay, J. Möller, R. Pörtner, B. Frahm, Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies, 2016.
ELSA
 
[8]
2015 | Konferenzband - Beitrag | ELSA-ID: 2819 | OA
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for cell passaging in cell culture seed trains, BioMed Central, 2015.
ELSA | DOI | Download (ext.)
 
[7]
2015 | Konferenz - Vortrag | ELSA-ID: 2917
B. Frahm, R. Pörtner, S. Kern, T. Hernández Rodriguez, Seed train design and optimization for animal cell suspension culture, 2015.
ELSA | Dateien verfügbar
 
[6]
2015 | Konferenz - Vortrag | ELSA-ID: 2919
B. Frahm, T. Hernández Rodriguez, S. Kern, K.S. Koopmann, U. Beshay, O. Platas-Barradas, R. Pörtner, Seed train design and optimization for animal cell suspension culture, 2015.
ELSA
 
[5]
2015 | Konferenz - Poster | ELSA-ID: 2985
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for cell passaging in cell culture seed trains, 2015.
ELSA
 
[4]
2015 | Konferenz - Poster | ELSA-ID: 2987
T. Hernández Rodriguez, R. Pörtner, B. Frahm, A software tool for biopharmaceutical seed train design and optimization, 2015.
ELSA
 
[3]
2015 | Konferenz - Poster | ELSA-ID: 2988
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for cell passaging in cell culture seed trains, 2015.
ELSA
 
[2]
2013 | Konferenzband - Beitrag | ELSA-ID: 2817 | OA
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed train optimization for suspension cell culture, BioMed Central , 2013.
ELSA | DOI | Download (ext.)
 
[1]
2013 | Konferenz - Poster | ELSA-ID: 2983
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed train optimization for suspension cell culture, 2013.
ELSA
 
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61 Publikationen

Alle markieren

[61]
2024 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 12402
P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator, Chemie Ingenieur Technik. 96 (2024) 528–534.
ELSA | DOI | WoS
 
[60]
2023 | Konferenz - Poster | ELSA-ID: 11381
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development, DECHEMA e.V., n.d.
ELSA
 
[59]
2023 | Konferenz - Poster | ELSA-ID: 11382 | OA
V. Gassenmeier, F. Kuhfuß, S. Deppe, G. Ifrim, T. Hernández Rodriguez, B. Frahm, View on a mechanistic model of Chlorella vulgaris in shake flasks, n.d.
ELSA | Download (ext.)
 
[58]
2023 | Konferenz - Vortrag | ELSA-ID: 11383
T. Hernández Rodriguez, C. Posch, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture, DECHEMA e.V., 2023.
ELSA
 
[57]
2023 | Konferenz - Poster | ELSA-ID: 11487 | OA
S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression , DECHEMA e.V., n.d.
ELSA | Download (ext.)
 
[56]
2023 | Konferenz - Poster | ELSA-ID: 10201 | OA
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development, 2023.
ELSA | Download (ext.)
 
[55]
2023 | Konferenzband - Beitrag | ELSA-ID: 10788 | OA
S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, IEEE, [Piscataway, NJ], 2023.
ELSA | DOI | Download (ext.)
 
[54]
2023 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11385
P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations, Chemie Ingenieur Technik. 95 (2023) 1960–1969.
ELSA | DOI | WoS
 
[53]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11377
T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design, Processes. 10 (2022).
ELSA | DOI
 
[52]
2022 | Konferenz - Poster | ELSA-ID: 7932
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development, n.d.
ELSA
 
[51]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7976
V. Gassenmeier, S. Deppe, T. Hernández Rodriguez, F. Kuhfuß, A. Moser, V.C. Hass, K.B. Kuchemüller, R. Pörtner, J. Möller, G.A. Ifrim, B. Frahm, Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology, Current Research in Biotechnology. 4 (2022) 102–119.
ELSA | DOI
 
[50]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7977
F. Kuhfuß, V. Gassenmeier, S. Deppe, G.A. Ifrim, T. Hernández Rodriguez, B. Frahm, View on a mechanistic model of Chlorella vulgaris in incubated shake flasks, Bioprocess and Biosystems Engineering. 45 (2022) 15–30.
ELSA | DOI
 
[49]
2022 | Sammelwerk - Beitrag | ELSA-ID: 10193
T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design, in: R. Pörtner, J. Möller (Eds.), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2022: pp. 21–48.
ELSA | DOI
 
[48]
2022 | Konferenz - Vortrag | ELSA-ID: 10197
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture, 2022.
ELSA
 
[47]
2022 | Konferenz - Poster | ELSA-ID: 10198
T. Hernández Rodriguez, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion, n.d.
ELSA
 
[46]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11376
T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study, Processes. 9 (2021).
ELSA | DOI
 
[45]
2021 | Konferenz - Vortrag | ELSA-ID: 7927
T. Hernández Rodriguez, B. Frahm, Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction, 2021.
ELSA
 
[44]
2021 | Konferenz - Poster | ELSA-ID: 7931
A. Moser, J. Möller, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, B. Frahm, R. Pörtner, V.C. Hass, Model-assisted Design of Experiments - Concept, Software and Applications, 2021.
ELSA
 
[43]
2021 | Sammelwerk - Beitrag | ELSA-ID: 7983
T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study, in: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2021: pp. 49–74.
ELSA | DOI
 
[42]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train, Bioprocess and Biosystems Engineering. 44 (2021) 793–808.
ELSA | DOI
 
[41]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7986
A. Moser, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, B. Frahm, R. Pörtner, V.C. Hass, J. Möller, Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses, Bioprocess and Biosystems Engineering. 44 (2021) 683–700.
ELSA | DOI
 
[40]
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
T. Hernández Rodriguez, B. Frahm, Digital Seed Train Twins and Statistical Methods, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digital Twins Tools and Concepts for Smart Biomanufacturing, Springer, Berlin, Heidelberg, 2021: pp. 97–131.
ELSA | DOI
 
[39]
2020 | Konferenz - Poster | ELSA-ID: 7929
T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration, 2020.
ELSA
 
[38]
2020 | Konferenz - Poster | ELSA-ID: 7930
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes, 2020.
ELSA
 
[37]
2020 | Konferenz - Vortrag | ELSA-ID: 7936
T. Hernández Rodriguez, B. Frahm, C. Posch, Integration of prior knowledge and digital tools for uncertainty-based decision support, 2020.
ELSA
 
[36]
2020 | Konferenzband - Beitrag | ELSA-ID: 7937
T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration, Wiley, 2020.
ELSA | DOI
 
[35]
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes, Wiley, 2020.
ELSA | DOI
 
[34]
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, Claus Weihs, R. Pörtner, B. Frahm, Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach, BioMed Central, 2020.
ELSA | Dateien verfügbar | DOI
 
[33]
2020 | Konferenz - Poster | ELSA-ID: 3007
F. Kuhfuß, M. Tölle, T. Hernández Rodriguez, V. Gassenmeier, S. Deppe, G.A. Ifrim, B. Frahm, Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration, 2020.
ELSA
 
[32]
2020 | Konferenz - Poster | ELSA-ID: 3008
S. Deppe, F. Kuhfuß, M. Tölle, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, J. Möller, R. Pörtner, A. Moser, V.C. Hass, B. Frahm, Model-assisted Design of Experiments for algae cultivation, 2020.
ELSA
 
[31]
2020 | Konferenz - Poster | ELSA-ID: 3009
G.A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, B. Frahm, Modeling of microalgae in an air-lift photobioreactor for biomass production, 2020.
ELSA
 
[30]
2019 | Konferenz - Vortrag | ELSA-ID: 2956
J. Möller, J. Müller, T. Hernández Rodriguez, K.B. Kuchemüller, L. Arndt, B. Frahm, R. Eibl, D. Eibl, R. Pörtner, Workflow for model-assisted design and scale-up of biopharmaceutical production processes, 2019.
ELSA
 
[29]
2019 | Konferenz - Vortrag | ELSA-ID: 2957
J. Möller, K.B. Kuchemüller, A. Moser, V.C. Hass, T. Hernández Rodriguez, S. Deppe, B. Frahm, R. Pörtner, Model-Assisted Design of Experiments, 2019.
ELSA
 
[28]
2019 | Konferenz - Poster | ELSA-ID: 3000
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019.
ELSA
 
[27]
2019 | Konferenz - Poster | ELSA-ID: 3001
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019.
ELSA
 
[26]
2019 | Konferenz - Poster | ELSA-ID: 3002
J. Möller, K.B. Kuchemüller, T. Hernández Rodriguez, S. Deppe, G.A. Ifrim, A. Moser, V.C. Hass, B. Frahm, R. Pörtner, Model-Assisted Design of Experiments – Software Toolbox, 2019.
ELSA
 
[25]
2019 | Konferenz - Poster | ELSA-ID: 3003
S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, M. Tölle, F. Kuhfuß, J. Möller, K.B. Kuchemüller, R. Pörtner, A. Moser, V.C. Hass, G.A. Ifrim, B. Frahm, Model-assisted Design of Experiments for algae cultivation, 2019.
ELSA
 
[24]
2019 | Konferenz - Poster | ELSA-ID: 3004
G.A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, B. Frahm, Modeling of microalgae in an air-lift photobioreactor for biomass production, 2019.
ELSA
 
[23]
2019 | Konferenz - Poster | ELSA-ID: 3005
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019.
ELSA
 
[22]
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 | OA
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, C. Weihs, R. Pörtner, B. Frahm, Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method, Biotechnology and Bioengineering. 116 (2019) 2944–2959.
ELSA | DOI | Download (ext.)
 
[21]
2018 | Konferenz - Vortrag | ELSA-ID: 7935
T. Hernández Rodriguez, B. Frahm, C. Posch, J. Schmutzhard, J. Stettner, A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization, 2018.
ELSA
 
[20]
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
T. Hernández Rodriguez, S. Krull, V.C. Hass, J. Möller, R. Pörtner, B. Frahm, Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization, BioMed Central, 2018.
ELSA | Dateien verfügbar | DOI
 
[19]
2018 | Konferenz - Poster | ELSA-ID: 2997
J. Möller, K.B. Kuchemüller, F. Freiberger, P. Levermann, T. Hernández Rodriguez, B. Frahm, V.C. Hass, R. Pörtner, Model-Assisted Design and Optimization of Process Strategies, 2018.
ELSA
 
[18]
2018 | Konferenz - Poster | ELSA-ID: 2999
T. Hernández Rodriguez, J. Möller, K.B. Kuchemüller, F. Freiberger, P. Levermann, V.C. Hass, B. Frahm, R. Pörtner, Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses, 2018.
ELSA
 
[17]
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 | OA
J. Möller, K.B. Kuchemüller, T. Hernández Rodriguez, B. Frahm, V.C. Hass, R. Pörtner, Model-Assisted Design of Process Strategies for Cell Culture Processes, American Pharmaceutical Review. 3 (2018) 39–41.
ELSA | Download (ext.)
 
[16]
2017 | Konferenz - Vortrag | ELSA-ID: 2920
T. Hernández Rodriguez, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017.
ELSA
 
[15]
2017 | Konferenz - Vortrag | ELSA-ID: 2921
R. Pörtner, J. Möller, T. Hernández Rodriguez, B. Frahm, V.C. Hass, Model-assisted design and optimization of biotechnological processes, 2017.
ELSA
 
[14]
2017 | Konferenz - Vortrag | ELSA-ID: 2950
T. Hernández Rodriguez, K.S. Koopmann, J. Klaes, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017.
ELSA
 
[13]
2017 | Konferenz - Poster | ELSA-ID: 2994
T. Hernández Rodriguez, K.S. Koopmann, R. Pörtner, B. Frahm, Influence of parameter accuracies in cell culture seed train simulations, 2017.
ELSA
 
[12]
2017 | Konferenz - Poster | ELSA-ID: 2995
T. Hernández Rodriguez, S. Krull, V.C. Hass, J. Möller, R. Pörtner, B. Frahm, Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization, 2017.
ELSA
 
[11]
2017 | Konferenz - Poster | ELSA-ID: 2996
T. Hernández Rodriguez, S. Krull, V.C. Hass, R. Pörtner, B. Frahm, Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization, 2017.
ELSA
 
[10]
2016 | Konferenz - Poster | ELSA-ID: 2992
T. Hernández Rodriguez, S. Vörtler, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, A software tool for biopharmaceutical seed train design and optimization, 2016.
ELSA
 
[9]
2016 | Konferenz - Poster | ELSA-ID: 2993
K.S. Koopmann, T. Hernández Rodriguez, S. Vörtler, U. Beshay, J. Möller, R. Pörtner, B. Frahm, Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies, 2016.
ELSA
 
[8]
2015 | Konferenzband - Beitrag | ELSA-ID: 2819 | OA
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for cell passaging in cell culture seed trains, BioMed Central, 2015.
ELSA | DOI | Download (ext.)
 
[7]
2015 | Konferenz - Vortrag | ELSA-ID: 2917
B. Frahm, R. Pörtner, S. Kern, T. Hernández Rodriguez, Seed train design and optimization for animal cell suspension culture, 2015.
ELSA | Dateien verfügbar
 
[6]
2015 | Konferenz - Vortrag | ELSA-ID: 2919
B. Frahm, T. Hernández Rodriguez, S. Kern, K.S. Koopmann, U. Beshay, O. Platas-Barradas, R. Pörtner, Seed train design and optimization for animal cell suspension culture, 2015.
ELSA
 
[5]
2015 | Konferenz - Poster | ELSA-ID: 2985
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for cell passaging in cell culture seed trains, 2015.
ELSA
 
[4]
2015 | Konferenz - Poster | ELSA-ID: 2987
T. Hernández Rodriguez, R. Pörtner, B. Frahm, A software tool for biopharmaceutical seed train design and optimization, 2015.
ELSA
 
[3]
2015 | Konferenz - Poster | ELSA-ID: 2988
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for cell passaging in cell culture seed trains, 2015.
ELSA
 
[2]
2013 | Konferenzband - Beitrag | ELSA-ID: 2817 | OA
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed train optimization for suspension cell culture, BioMed Central , 2013.
ELSA | DOI | Download (ext.)
 
[1]
2013 | Konferenz - Poster | ELSA-ID: 2983
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed train optimization for suspension cell culture, 2013.
ELSA
 
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