61 Publikationen

Alle markieren

[61]
2024 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 12402
Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator
P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Chemie Ingenieur Technik 96 (2024) 528–534.
ELSA | DOI | WoS
 
[60]
2023 | Konferenzband - Beitrag | ELSA-ID: 10788 | OA
Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities
S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, IEEE, [Piscataway, NJ], 2023.
ELSA | DOI | Download (ext.)
 
[59]
2023 | Konferenz - Poster | ELSA-ID: 11381
A systematic, model-based workflow for risk-based decision making in upstream development
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, DECHEMA e.V., n.d.
ELSA
 
[58]
2023 | Konferenz - Poster | ELSA-ID: 11382 | OA
View on a mechanistic model of Chlorella vulgaris in shake flasks
V. Gassenmeier, F. Kuhfuß, S. Deppe, G. Ifrim, T. Hernández Rodriguez, B. Frahm, View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks, n.d.
ELSA | Download (ext.)
 
[57]
2023 | Konferenz - Vortrag | ELSA-ID: 11383
Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture
T. Hernández Rodriguez, C. Posch, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture, DECHEMA e.V., 2023.
ELSA
 
[56]
2023 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11385
Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations
P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Chemie Ingenieur Technik 95 (2023) 1960–1969.
ELSA | DOI | WoS
 
[55]
2023 | Konferenz - Poster | ELSA-ID: 11487 | OA
Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression
S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression , DECHEMA e.V., n.d.
ELSA | Download (ext.)
 
[54]
2023 | Konferenz - Poster | ELSA-ID: 10201 | OA
A systematic, model-based workflow for risk-based decision making in upstream development
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, 2023.
ELSA | Download (ext.)
 
[53]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11377 ELSA | DOI
 
[52]
2022 | Konferenz - Poster | ELSA-ID: 7932
A systematic, model-based workflow for risk-based decision making in upstream development
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, n.d.
ELSA
 
[51]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7976
Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology
V. Gassenmeier, S. Deppe, T. Hernández Rodriguez, F. Kuhfuß, A. Moser, V.C. Hass, K.B. Kuchemüller, R. Pörtner, J. Möller, G.A. Ifrim, B. Frahm, Current Research in Biotechnology 4 (2022) 102–119.
ELSA | DOI
 
[50]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7977
View on a mechanistic model of Chlorella vulgaris in incubated shake flasks
F. Kuhfuß, V. Gassenmeier, S. Deppe, G.A. Ifrim, T. Hernández Rodriguez, B. Frahm, Bioprocess and Biosystems Engineering 45 (2022) 15–30.
ELSA | DOI
 
[49]
2022 | Sammelwerk - Beitrag | ELSA-ID: 10193
Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design
T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, in: R. Pörtner, J. Möller (Eds.), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2022, pp. 21–48.
ELSA | DOI
 
[48]
2022 | Konferenz - Vortrag | ELSA-ID: 10197
Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Model Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture, 2022.
ELSA
 
[47]
2022 | Konferenz - Poster | ELSA-ID: 10198
A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion
T. Hernández Rodriguez, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, A Systematic, Model-Based Approach for Decision Making in Upstream Development – Considerations Regarding Clone Selection and Cell Expansion, n.d.
ELSA
 
[46]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11376
Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study
T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Processes 9 (2021).
ELSA | DOI
 
[45]
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
Digital Seed Train Twins and Statistical Methods
T. Hernández Rodriguez, B. Frahm, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digital Twins Tools and Concepts for Smart Biomanufacturing, Springer, Berlin, Heidelberg, 2021, pp. 97–131.
ELSA | DOI
 
[44]
2021 | Konferenz - Vortrag | ELSA-ID: 7927
Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction
T. Hernández Rodriguez, B. Frahm, Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction, 2021.
ELSA
 
[43]
2021 | Konferenz - Poster | ELSA-ID: 7931
Model-assisted Design of Experiments - Concept, Software and Applications
A. Moser, J. Möller, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, B. Frahm, R. Pörtner, V.C. Hass, Model-Assisted Design of Experiments - Concept, Software and Applications, 2021.
ELSA
 
[42]
2021 | Sammelwerk - Beitrag | ELSA-ID: 7983
Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study
T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, in: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2021, pp. 49–74.
ELSA | DOI
 
[41]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Bioprocess and Biosystems Engineering 44 (2021) 793–808.
ELSA | DOI
 
[40]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7986
Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses
A. Moser, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, B. Frahm, R. Pörtner, V.C. Hass, J. Möller, Bioprocess and Biosystems Engineering 44 (2021) 683–700.
ELSA | DOI
 
[39]
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, Claus Weihs, R. Pörtner, B. Frahm, Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach, BioMed Central, 2020.
ELSA | Dateien verfügbar | DOI
 
[38]
2020 | Konferenz - Poster | ELSA-ID: 3007
Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration
F. Kuhfuß, M. Tölle, T. Hernández Rodriguez, V. Gassenmeier, S. Deppe, G.A. Ifrim, B. Frahm, Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration, 2020.
ELSA
 
[37]
2020 | Konferenz - Poster | ELSA-ID: 3008
Model-assisted Design of Experiments for algae cultivation
S. Deppe, F. Kuhfuß, M. Tölle, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, J. Möller, R. Pörtner, A. Moser, V.C. Hass, B. Frahm, Model-Assisted Design of Experiments for Algae Cultivation, 2020.
ELSA
 
[36]
2020 | Konferenz - Poster | ELSA-ID: 3009
Modeling of microalgae in an air-lift photobioreactor for biomass production
G.A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, B. Frahm, Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production, 2020.
ELSA
 
[35]
2020 | Konferenz - Poster | ELSA-ID: 7929
Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration
T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration, 2020.
ELSA
 
[34]
2020 | Konferenz - Poster | ELSA-ID: 7930
Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes, 2020.
ELSA
 
[33]
2020 | Konferenz - Vortrag | ELSA-ID: 7936
Integration of prior knowledge and digital tools for uncertainty-based decision support
T. Hernández Rodriguez, B. Frahm, C. Posch, Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support, 2020.
ELSA
 
[32]
2020 | Konferenzband - Beitrag | ELSA-ID: 7937
Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration
T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella Vulgaris Algae in Shake Flasks with Respect to Light Intensity and Light Duration, Wiley, 2020.
ELSA | DOI
 
[31]
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes, Wiley, 2020.
ELSA | DOI
 
[30]
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 | OA ELSA | DOI | Download (ext.)
 
[29]
2019 | Konferenz - Vortrag | ELSA-ID: 2956
Workflow for model-assisted design and scale-up of biopharmaceutical production processes
J. Möller, J. Müller, T. Hernández Rodriguez, K.B. Kuchemüller, L. Arndt, B. Frahm, R. Eibl, D. Eibl, R. Pörtner, Workflow for Model-Assisted Design and Scale-up of Biopharmaceutical Production Processes, 2019.
ELSA
 
[28]
2019 | Konferenz - Vortrag | ELSA-ID: 2957
Model-Assisted Design of Experiments
J. Möller, K.B. Kuchemüller, A. Moser, V.C. Hass, T. Hernández Rodriguez, S. Deppe, B. Frahm, R. Pörtner, Model-Assisted Design of Experiments, 2019.
ELSA
 
[27]
2019 | Konferenz - Poster | ELSA-ID: 3000
Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating, 2019.
ELSA
 
[26]
2019 | Konferenz - Poster | ELSA-ID: 3001
Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating, 2019.
ELSA
 
[25]
2019 | Konferenz - Poster | ELSA-ID: 3002
Model-Assisted Design of Experiments – Software Toolbox
J. Möller, K.B. Kuchemüller, T. Hernández Rodriguez, S. Deppe, G.A. Ifrim, A. Moser, V.C. Hass, B. Frahm, R. Pörtner, Model-Assisted Design of Experiments – Software Toolbox, 2019.
ELSA
 
[24]
2019 | Konferenz - Poster | ELSA-ID: 3003
Model-assisted Design of Experiments for algae cultivation
S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, M. Tölle, F. Kuhfuß, J. Möller, K.B. Kuchemüller, R. Pörtner, A. Moser, V.C. Hass, G.A. Ifrim, B. Frahm, Model-Assisted Design of Experiments for Algae Cultivation, 2019.
ELSA
 
[23]
2019 | Konferenz - Poster | ELSA-ID: 3004
Modeling of microalgae in an air-lift photobioreactor for biomass production
G.A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, B. Frahm, Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production, 2019.
ELSA
 
[22]
2019 | Konferenz - Poster | ELSA-ID: 3005
Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating, 2019.
ELSA
 
[21]
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 | OA
Model-Assisted Design of Process Strategies for Cell Culture Processes
J. Möller, K.B. Kuchemüller, T. Hernández Rodriguez, B. Frahm, V.C. Hass, R. Pörtner, American Pharmaceutical Review 3 (2018) 39–41.
ELSA | Download (ext.)
 
[20]
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization
T. Hernández Rodriguez, S. Krull, V.C. Hass, J. Möller, R. Pörtner, B. Frahm, Model-Assisted Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization, BioMed Central, 2018.
ELSA | Dateien verfügbar | DOI
 
[19]
2018 | Konferenz - Poster | ELSA-ID: 2997
Model-Assisted Design and Optimization of Process Strategies
J. Möller, K.B. Kuchemüller, F. Freiberger, P. Levermann, T. Hernández Rodriguez, B. Frahm, V.C. Hass, R. Pörtner, Model-Assisted Design and Optimization of Process Strategies, 2018.
ELSA
 
[18]
2018 | Konferenz - Poster | ELSA-ID: 2999
Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses
T. Hernández Rodriguez, J. Möller, K.B. Kuchemüller, F. Freiberger, P. Levermann, V.C. Hass, B. Frahm, R. Pörtner, Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses, 2018.
ELSA
 
[17]
2018 | Konferenz - Vortrag | ELSA-ID: 7935
A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization
T. Hernández Rodriguez, B. Frahm, C. Posch, J. Schmutzhard, J. Stettner, A Model-Assisted Approach for Design, Optimization and Control of Bioprocesses – a Software Tool for Seed Train Simulation and Optimization, 2018.
ELSA
 
[16]
2017 | Konferenz - Vortrag | ELSA-ID: 2920
Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren
T. Hernández Rodriguez, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017.
ELSA
 
[15]
2017 | Konferenz - Vortrag | ELSA-ID: 2921
Model-assisted design and optimization of biotechnological processes
R. Pörtner, J. Möller, T. Hernández Rodriguez, B. Frahm, V.C. Hass, Model-Assisted Design and Optimization of Biotechnological Processes, 2017.
ELSA
 
[14]
2017 | Konferenz - Vortrag | ELSA-ID: 2950
Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren
T. Hernández Rodriguez, K.S. Koopmann, J. Klaes, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017.
ELSA
 
[13]
2017 | Konferenz - Poster | ELSA-ID: 2994
Influence of parameter accuracies in cell culture seed train simulations
T. Hernández Rodriguez, K.S. Koopmann, R. Pörtner, B. Frahm, Influence of Parameter Accuracies in Cell Culture Seed Train Simulations, 2017.
ELSA
 
[12]
2017 | Konferenz - Poster | ELSA-ID: 2995
Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization
T. Hernández Rodriguez, S. Krull, V.C. Hass, J. Möller, R. Pörtner, B. Frahm, Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization, 2017.
ELSA
 
[11]
2017 | Konferenz - Poster | ELSA-ID: 2996
Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization
T. Hernández Rodriguez, S. Krull, V.C. Hass, R. Pörtner, B. Frahm, Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization, 2017.
ELSA
 
[10]
2016 | Konferenz - Poster | ELSA-ID: 2992
A software tool for biopharmaceutical seed train design and optimization
T. Hernández Rodriguez, S. Vörtler, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, A Software Tool for Biopharmaceutical Seed Train Design and Optimization, 2016.
ELSA
 
[9]
2016 | Konferenz - Poster | ELSA-ID: 2993
Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies
K.S. Koopmann, T. Hernández Rodriguez, S. Vörtler, U. Beshay, J. Möller, R. Pörtner, B. Frahm, Simulation of Cell Culture Seed Trains – Investigation of the Influence of Parameter Inaccuracies, 2016.
ELSA
 
[8]
2015 | Konferenzband - Beitrag | ELSA-ID: 2819 | OA
Considerations for cell passaging in cell culture seed trains
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for Cell Passaging in Cell Culture Seed Trains, BioMed Central, 2015.
ELSA | DOI | Download (ext.)
 
[7]
2015 | Konferenz - Vortrag | ELSA-ID: 2917
Seed train design and optimization for animal cell suspension culture
B. Frahm, R. Pörtner, S. Kern, T. Hernández Rodriguez, Seed Train Design and Optimization for Animal Cell Suspension Culture, 2015.
ELSA | Dateien verfügbar
 
[6]
2015 | Konferenz - Vortrag | ELSA-ID: 2919
Seed train design and optimization for animal cell suspension culture
B. Frahm, T. Hernández Rodriguez, S. Kern, K.S. Koopmann, U. Beshay, O. Platas-Barradas, R. Pörtner, Seed Train Design and Optimization for Animal Cell Suspension Culture, 2015.
ELSA
 
[5]
2015 | Konferenz - Poster | ELSA-ID: 2985
Considerations for cell passaging in cell culture seed trains
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for Cell Passaging in Cell Culture Seed Trains, 2015.
ELSA
 
[4]
2015 | Konferenz - Poster | ELSA-ID: 2987
A software tool for biopharmaceutical seed train design and optimization
T. Hernández Rodriguez, R. Pörtner, B. Frahm, A Software Tool for Biopharmaceutical Seed Train Design and Optimization, 2015.
ELSA
 
[3]
2015 | Konferenz - Poster | ELSA-ID: 2988
Considerations for cell passaging in cell culture seed trains
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for Cell Passaging in Cell Culture Seed Trains, 2015.
ELSA
 
[2]
2013 | Konferenzband - Beitrag | ELSA-ID: 2817 | OA
Seed train optimization for suspension cell culture
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed Train Optimization for Suspension Cell Culture, BioMed Central , 2013.
ELSA | DOI | Download (ext.)
 
[1]
2013 | Konferenz - Poster | ELSA-ID: 2983
Seed train optimization for suspension cell culture
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed Train Optimization for Suspension Cell Culture, 2013.
ELSA
 

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61 Publikationen

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[61]
2024 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 12402
Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator
P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Chemie Ingenieur Technik 96 (2024) 528–534.
ELSA | DOI | WoS
 
[60]
2023 | Konferenzband - Beitrag | ELSA-ID: 10788 | OA
Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities
S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, IEEE, [Piscataway, NJ], 2023.
ELSA | DOI | Download (ext.)
 
[59]
2023 | Konferenz - Poster | ELSA-ID: 11381
A systematic, model-based workflow for risk-based decision making in upstream development
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, DECHEMA e.V., n.d.
ELSA
 
[58]
2023 | Konferenz - Poster | ELSA-ID: 11382 | OA
View on a mechanistic model of Chlorella vulgaris in shake flasks
V. Gassenmeier, F. Kuhfuß, S. Deppe, G. Ifrim, T. Hernández Rodriguez, B. Frahm, View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks, n.d.
ELSA | Download (ext.)
 
[57]
2023 | Konferenz - Vortrag | ELSA-ID: 11383
Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture
T. Hernández Rodriguez, C. Posch, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture, DECHEMA e.V., 2023.
ELSA
 
[56]
2023 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11385
Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations
P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Chemie Ingenieur Technik 95 (2023) 1960–1969.
ELSA | DOI | WoS
 
[55]
2023 | Konferenz - Poster | ELSA-ID: 11487 | OA
Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression
S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression , DECHEMA e.V., n.d.
ELSA | Download (ext.)
 
[54]
2023 | Konferenz - Poster | ELSA-ID: 10201 | OA
A systematic, model-based workflow for risk-based decision making in upstream development
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, 2023.
ELSA | Download (ext.)
 
[53]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11377 ELSA | DOI
 
[52]
2022 | Konferenz - Poster | ELSA-ID: 7932
A systematic, model-based workflow for risk-based decision making in upstream development
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, n.d.
ELSA
 
[51]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7976
Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology
V. Gassenmeier, S. Deppe, T. Hernández Rodriguez, F. Kuhfuß, A. Moser, V.C. Hass, K.B. Kuchemüller, R. Pörtner, J. Möller, G.A. Ifrim, B. Frahm, Current Research in Biotechnology 4 (2022) 102–119.
ELSA | DOI
 
[50]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7977
View on a mechanistic model of Chlorella vulgaris in incubated shake flasks
F. Kuhfuß, V. Gassenmeier, S. Deppe, G.A. Ifrim, T. Hernández Rodriguez, B. Frahm, Bioprocess and Biosystems Engineering 45 (2022) 15–30.
ELSA | DOI
 
[49]
2022 | Sammelwerk - Beitrag | ELSA-ID: 10193
Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design
T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, in: R. Pörtner, J. Möller (Eds.), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2022, pp. 21–48.
ELSA | DOI
 
[48]
2022 | Konferenz - Vortrag | ELSA-ID: 10197
Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Model Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture, 2022.
ELSA
 
[47]
2022 | Konferenz - Poster | ELSA-ID: 10198
A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion
T. Hernández Rodriguez, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, A Systematic, Model-Based Approach for Decision Making in Upstream Development – Considerations Regarding Clone Selection and Cell Expansion, n.d.
ELSA
 
[46]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11376
Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study
T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Processes 9 (2021).
ELSA | DOI
 
[45]
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
Digital Seed Train Twins and Statistical Methods
T. Hernández Rodriguez, B. Frahm, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digital Twins Tools and Concepts for Smart Biomanufacturing, Springer, Berlin, Heidelberg, 2021, pp. 97–131.
ELSA | DOI
 
[44]
2021 | Konferenz - Vortrag | ELSA-ID: 7927
Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction
T. Hernández Rodriguez, B. Frahm, Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction, 2021.
ELSA
 
[43]
2021 | Konferenz - Poster | ELSA-ID: 7931
Model-assisted Design of Experiments - Concept, Software and Applications
A. Moser, J. Möller, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, B. Frahm, R. Pörtner, V.C. Hass, Model-Assisted Design of Experiments - Concept, Software and Applications, 2021.
ELSA
 
[42]
2021 | Sammelwerk - Beitrag | ELSA-ID: 7983
Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study
T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, in: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2021, pp. 49–74.
ELSA | DOI
 
[41]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Bioprocess and Biosystems Engineering 44 (2021) 793–808.
ELSA | DOI
 
[40]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7986
Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses
A. Moser, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, B. Frahm, R. Pörtner, V.C. Hass, J. Möller, Bioprocess and Biosystems Engineering 44 (2021) 683–700.
ELSA | DOI
 
[39]
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, Claus Weihs, R. Pörtner, B. Frahm, Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach, BioMed Central, 2020.
ELSA | Dateien verfügbar | DOI
 
[38]
2020 | Konferenz - Poster | ELSA-ID: 3007
Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration
F. Kuhfuß, M. Tölle, T. Hernández Rodriguez, V. Gassenmeier, S. Deppe, G.A. Ifrim, B. Frahm, Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration, 2020.
ELSA
 
[37]
2020 | Konferenz - Poster | ELSA-ID: 3008
Model-assisted Design of Experiments for algae cultivation
S. Deppe, F. Kuhfuß, M. Tölle, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, J. Möller, R. Pörtner, A. Moser, V.C. Hass, B. Frahm, Model-Assisted Design of Experiments for Algae Cultivation, 2020.
ELSA
 
[36]
2020 | Konferenz - Poster | ELSA-ID: 3009
Modeling of microalgae in an air-lift photobioreactor for biomass production
G.A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, B. Frahm, Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production, 2020.
ELSA
 
[35]
2020 | Konferenz - Poster | ELSA-ID: 7929
Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration
T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration, 2020.
ELSA
 
[34]
2020 | Konferenz - Poster | ELSA-ID: 7930
Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes, 2020.
ELSA
 
[33]
2020 | Konferenz - Vortrag | ELSA-ID: 7936
Integration of prior knowledge and digital tools for uncertainty-based decision support
T. Hernández Rodriguez, B. Frahm, C. Posch, Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support, 2020.
ELSA
 
[32]
2020 | Konferenzband - Beitrag | ELSA-ID: 7937
Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration
T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella Vulgaris Algae in Shake Flasks with Respect to Light Intensity and Light Duration, Wiley, 2020.
ELSA | DOI
 
[31]
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes, Wiley, 2020.
ELSA | DOI
 
[30]
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 | OA ELSA | DOI | Download (ext.)
 
[29]
2019 | Konferenz - Vortrag | ELSA-ID: 2956
Workflow for model-assisted design and scale-up of biopharmaceutical production processes
J. Möller, J. Müller, T. Hernández Rodriguez, K.B. Kuchemüller, L. Arndt, B. Frahm, R. Eibl, D. Eibl, R. Pörtner, Workflow for Model-Assisted Design and Scale-up of Biopharmaceutical Production Processes, 2019.
ELSA
 
[28]
2019 | Konferenz - Vortrag | ELSA-ID: 2957
Model-Assisted Design of Experiments
J. Möller, K.B. Kuchemüller, A. Moser, V.C. Hass, T. Hernández Rodriguez, S. Deppe, B. Frahm, R. Pörtner, Model-Assisted Design of Experiments, 2019.
ELSA
 
[27]
2019 | Konferenz - Poster | ELSA-ID: 3000
Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating, 2019.
ELSA
 
[26]
2019 | Konferenz - Poster | ELSA-ID: 3001
Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating, 2019.
ELSA
 
[25]
2019 | Konferenz - Poster | ELSA-ID: 3002
Model-Assisted Design of Experiments – Software Toolbox
J. Möller, K.B. Kuchemüller, T. Hernández Rodriguez, S. Deppe, G.A. Ifrim, A. Moser, V.C. Hass, B. Frahm, R. Pörtner, Model-Assisted Design of Experiments – Software Toolbox, 2019.
ELSA
 
[24]
2019 | Konferenz - Poster | ELSA-ID: 3003
Model-assisted Design of Experiments for algae cultivation
S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, M. Tölle, F. Kuhfuß, J. Möller, K.B. Kuchemüller, R. Pörtner, A. Moser, V.C. Hass, G.A. Ifrim, B. Frahm, Model-Assisted Design of Experiments for Algae Cultivation, 2019.
ELSA
 
[23]
2019 | Konferenz - Poster | ELSA-ID: 3004
Modeling of microalgae in an air-lift photobioreactor for biomass production
G.A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, B. Frahm, Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production, 2019.
ELSA
 
[22]
2019 | Konferenz - Poster | ELSA-ID: 3005
Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating, 2019.
ELSA
 
[21]
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 | OA
Model-Assisted Design of Process Strategies for Cell Culture Processes
J. Möller, K.B. Kuchemüller, T. Hernández Rodriguez, B. Frahm, V.C. Hass, R. Pörtner, American Pharmaceutical Review 3 (2018) 39–41.
ELSA | Download (ext.)
 
[20]
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization
T. Hernández Rodriguez, S. Krull, V.C. Hass, J. Möller, R. Pörtner, B. Frahm, Model-Assisted Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization, BioMed Central, 2018.
ELSA | Dateien verfügbar | DOI
 
[19]
2018 | Konferenz - Poster | ELSA-ID: 2997
Model-Assisted Design and Optimization of Process Strategies
J. Möller, K.B. Kuchemüller, F. Freiberger, P. Levermann, T. Hernández Rodriguez, B. Frahm, V.C. Hass, R. Pörtner, Model-Assisted Design and Optimization of Process Strategies, 2018.
ELSA
 
[18]
2018 | Konferenz - Poster | ELSA-ID: 2999
Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses
T. Hernández Rodriguez, J. Möller, K.B. Kuchemüller, F. Freiberger, P. Levermann, V.C. Hass, B. Frahm, R. Pörtner, Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses, 2018.
ELSA
 
[17]
2018 | Konferenz - Vortrag | ELSA-ID: 7935
A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization
T. Hernández Rodriguez, B. Frahm, C. Posch, J. Schmutzhard, J. Stettner, A Model-Assisted Approach for Design, Optimization and Control of Bioprocesses – a Software Tool for Seed Train Simulation and Optimization, 2018.
ELSA
 
[16]
2017 | Konferenz - Vortrag | ELSA-ID: 2920
Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren
T. Hernández Rodriguez, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017.
ELSA
 
[15]
2017 | Konferenz - Vortrag | ELSA-ID: 2921
Model-assisted design and optimization of biotechnological processes
R. Pörtner, J. Möller, T. Hernández Rodriguez, B. Frahm, V.C. Hass, Model-Assisted Design and Optimization of Biotechnological Processes, 2017.
ELSA
 
[14]
2017 | Konferenz - Vortrag | ELSA-ID: 2950
Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren
T. Hernández Rodriguez, K.S. Koopmann, J. Klaes, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017.
ELSA
 
[13]
2017 | Konferenz - Poster | ELSA-ID: 2994
Influence of parameter accuracies in cell culture seed train simulations
T. Hernández Rodriguez, K.S. Koopmann, R. Pörtner, B. Frahm, Influence of Parameter Accuracies in Cell Culture Seed Train Simulations, 2017.
ELSA
 
[12]
2017 | Konferenz - Poster | ELSA-ID: 2995
Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization
T. Hernández Rodriguez, S. Krull, V.C. Hass, J. Möller, R. Pörtner, B. Frahm, Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization, 2017.
ELSA
 
[11]
2017 | Konferenz - Poster | ELSA-ID: 2996
Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization
T. Hernández Rodriguez, S. Krull, V.C. Hass, R. Pörtner, B. Frahm, Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization, 2017.
ELSA
 
[10]
2016 | Konferenz - Poster | ELSA-ID: 2992
A software tool for biopharmaceutical seed train design and optimization
T. Hernández Rodriguez, S. Vörtler, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, A Software Tool for Biopharmaceutical Seed Train Design and Optimization, 2016.
ELSA
 
[9]
2016 | Konferenz - Poster | ELSA-ID: 2993
Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies
K.S. Koopmann, T. Hernández Rodriguez, S. Vörtler, U. Beshay, J. Möller, R. Pörtner, B. Frahm, Simulation of Cell Culture Seed Trains – Investigation of the Influence of Parameter Inaccuracies, 2016.
ELSA
 
[8]
2015 | Konferenzband - Beitrag | ELSA-ID: 2819 | OA
Considerations for cell passaging in cell culture seed trains
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for Cell Passaging in Cell Culture Seed Trains, BioMed Central, 2015.
ELSA | DOI | Download (ext.)
 
[7]
2015 | Konferenz - Vortrag | ELSA-ID: 2917
Seed train design and optimization for animal cell suspension culture
B. Frahm, R. Pörtner, S. Kern, T. Hernández Rodriguez, Seed Train Design and Optimization for Animal Cell Suspension Culture, 2015.
ELSA | Dateien verfügbar
 
[6]
2015 | Konferenz - Vortrag | ELSA-ID: 2919
Seed train design and optimization for animal cell suspension culture
B. Frahm, T. Hernández Rodriguez, S. Kern, K.S. Koopmann, U. Beshay, O. Platas-Barradas, R. Pörtner, Seed Train Design and Optimization for Animal Cell Suspension Culture, 2015.
ELSA
 
[5]
2015 | Konferenz - Poster | ELSA-ID: 2985
Considerations for cell passaging in cell culture seed trains
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for Cell Passaging in Cell Culture Seed Trains, 2015.
ELSA
 
[4]
2015 | Konferenz - Poster | ELSA-ID: 2987
A software tool for biopharmaceutical seed train design and optimization
T. Hernández Rodriguez, R. Pörtner, B. Frahm, A Software Tool for Biopharmaceutical Seed Train Design and Optimization, 2015.
ELSA
 
[3]
2015 | Konferenz - Poster | ELSA-ID: 2988
Considerations for cell passaging in cell culture seed trains
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for Cell Passaging in Cell Culture Seed Trains, 2015.
ELSA
 
[2]
2013 | Konferenzband - Beitrag | ELSA-ID: 2817 | OA
Seed train optimization for suspension cell culture
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed Train Optimization for Suspension Cell Culture, BioMed Central , 2013.
ELSA | DOI | Download (ext.)
 
[1]
2013 | Konferenz - Poster | ELSA-ID: 2983
Seed train optimization for suspension cell culture
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed Train Optimization for Suspension Cell Culture, 2013.
ELSA
 

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