168 Publikationen
2024 | Konferenz - Vortrag | ELSA-ID: 12021
Segermann J et al. (2024) Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie. .
ELSA
2024 | Konferenz - Vortrag | ELSA-ID: 12022
Luttmann M et al. (2024) Erkenntnisse zur Nutzung von Photogrammmetrie für die Untersuchung des Bräunungsverhaltens von Weizenbrötchen. .
ELSA
2024 | Konferenz - Poster | ELSA-ID: 12395
Müller C et al. (2024) Investigation of Microbial Spoilage in Vegan Foods. .
ELSA
2024 | Konferenz - Poster | ELSA-ID: 12396
Gassenmeier V, Campolongo G and Frahm B (2024) Dissolved Carbon Dioxide in Addition to Dissolved Oxygen for In-Situ Monitoring of Hybridoma Cell Culture. .
ELSA
2024 | Konferenz - Poster | ELSA-ID: 12397
Blome A et al. (2024) Process Optimization in Baked Goods Production Using Inline Sensors and Objective Product Evaluation. .
ELSA
2024 | Preprint | ELSA-ID: 12400 |

Ramm S et al. (2024) Semi-Automated vs. Manual: Comparative Study of Cell Culture Counting Methods Using Validation Parameters.
ELSA
| DOI
| Download (ext.)
2024 | Konferenz - Poster | ELSA-ID: 10957
Reinhardt L et al. (n.d.) Mycelium-Based Materials from Residues of the Regional Wood Industry. .
ELSA
2023 | Konferenz - Poster | ELSA-ID: 11378
Gassenmeier V, Campolongo G and Frahm B (n.d.) Real-Time Monitoring of DCO2 in Addition to DO. .
ELSA
2023 | Konferenz - Poster | ELSA-ID: 11381
Hernández Rodriguez T et al. (n.d.) A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. DECHEMA e.V.
ELSA
2023 | Konferenz - Poster | ELSA-ID: 11382 |

Gassenmeier V et al. (n.d.) View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks. .
ELSA
| Download (ext.)
2023 | Konferenz - Vortrag | ELSA-ID: 11383
Hernández Rodriguez T et al. (2023) Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture. DECHEMA e.V.
ELSA
2023 | Konferenzband - Beitrag | ELSA-ID: 11384 |

Müller C et al. (2023) Microbial Spoilage in Vegan Foods. Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draženka Komes, Sanja Vidaček Filipec and Bojana Voučko.
ELSA
| Download (ext.)
2023 | Konferenz - Poster | ELSA-ID: 11487 |

Ramm S et al. (n.d.) Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression . DECHEMA e.V.
ELSA
| Download (ext.)
2023 | Konferenz - Poster | ELSA-ID: 10201 |

Hernández Rodriguez T et al. (2023) A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. .
ELSA
| Download (ext.)
2023 | Konferenz - Vortrag | ELSA-ID: 11109
Blome A et al. (2023) Untersuchung der räumlichen Verteilung von viskoelastischen Kenngrößen während der Weizenteigbereitung. .
ELSA
2023 | Konferenz - Poster | ELSA-ID: 11110
Blome A et al. (2023) Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung. .
ELSA
2023 | Konferenz - Poster | ELSA-ID: 12483
Blome A et al. (2023) Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung. .
ELSA
2023 | Konferenz - Poster | ELSA-ID: 12485
Luttmann M et al. (2023) Teig 4.0 - Promotionsthemen. .
ELSA
2023 | Konferenzband - Beitrag | ELSA-ID: 10788 |

Ramm S et al. (2023) Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, Jasperneite J et al. (eds). [Piscataway, NJ]: IEEE.
ELSA
| DOI
| Download (ext.)
2022 | Konferenz - Poster | ELSA-ID: 7932
Hernández Rodriguez T et al. (n.d.) A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. .
ELSA
2022 | Datenpublikation | ELSA-ID: 10190
Gassenmeier V and Frahm B (2022) Real-Time Monitoring of DCO2 in Addition to DO. assets-labs.
ELSA
| Dateien verfügbar
2022 | Sammelwerk - Beitrag | ELSA-ID: 10193
Hernández Rodriguez T et al. (2022) Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. In Pörtner R and Möller J (eds), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, vol. special issue. Basel: MDPI, pp. 21–48.
ELSA
| DOI
2022 | Konferenzband - Beitrag | ELSA-ID: 10195
Blome A et al. (2022) Process Optimisation in the Field of Wheat Dough Processing Using Real-Time Recording of Quality-Relevant Characteristics in Raw Materials, Intermediates and Final Products. Versuchsanstalt der Hefeindustrie e.V.
ELSA
2022 | Konferenz - Vortrag | ELSA-ID: 10196
Blome A et al. (2022) Process Optimisation in the Field of Wheat Dough Processing Using Real-Time Recording of Quality-Relevant Characteristics in Raw Materials, Intermediates and Final Products. .
ELSA
2022 | Konferenz - Vortrag | ELSA-ID: 10197
Hernández Rodriguez T et al. (2022) Model Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture. .
ELSA
2022 | Konferenz - Poster | ELSA-ID: 10198
Hernández Rodriguez T et al. (n.d.) A Systematic, Model-Based Approach for Decision Making in Upstream Development – Considerations Regarding Clone Selection and Cell Expansion. .
ELSA
2022 | Konferenz - Poster | ELSA-ID: 10199 |

Müller C et al. (2022) Microbial Spoilage in Vegan Foods. .
ELSA
| Download (ext.)
2021 | Konferenz - Vortrag | ELSA-ID: 7927
Hernández Rodriguez T and Frahm B (2021) Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction. .
ELSA
2021 | Konferenz - Poster | ELSA-ID: 7931
Moser A et al. (2021) Model-Assisted Design of Experiments - Concept, Software and Applications. .
ELSA
2021 | Lexikoneintrag | ELSA-ID: 7939
Wirtanen G et al. (2021) Bovine Colostrum for Human Consumption. MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science.
ELSA
2021 | Sammelwerk - Beitrag | ELSA-ID: 7983
Hernández Rodriguez T et al. (2021) Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection – a Simulation Study. Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, vol. special issue. Basel: MDPI, pp. 49–74.
ELSA
| DOI
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
Hernández Rodriguez T et al. (2021) Dynamic Parameter Estimation and Prediction over Consecutive Scales, Based on Moving Horizon Estimation - Applied to an Industrial Cell Culture Seed Train. Bioprocess and Biosystems Engineering 44, 793–808.
ELSA
| DOI
2021 | Konferenz - Vortrag | ELSA-ID: 8078
Blome A et al. (2021) Messtechnikkonzepte Für Die Erfassung von Qualitätsrelevanten Parametern Und Merkmalen Bei Der Weizenteigverarbeitung. .
ELSA
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
Hernández Rodriguez T and Frahm B (2021) Digital Seed Train Twins and Statistical Methods. In Herwig C, Pörtner R and Möller J (eds), Digital Twins Tools and Concepts for Smart Biomanufacturing, vol. 176. Berlin, Heidelberg: Springer, pp. 97–131.
ELSA
| DOI
2020 | Konferenz - Poster | ELSA-ID: 7929
Hernández Rodriguez T et al. (2020) Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration. .
ELSA
2020 | Konferenz - Poster | ELSA-ID: 7930
Hernández Rodriguez T et al. (2020) Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes. .
ELSA
2020 | Konferenz - Vortrag | ELSA-ID: 7936
Hernández Rodriguez T, Frahm B and Posch C (2020) Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support. .
ELSA
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
Hernández Rodriguez T et al. (2020) Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach. BioMed Central.
ELSA
| Dateien verfügbar
| DOI
2020 | Konferenz - Poster | ELSA-ID: 3007
Kuhfuß F et al. (2020) Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration. .
ELSA
2020 | Konferenz - Poster | ELSA-ID: 3008
Deppe S et al. (2020) Model-Assisted Design of Experiments for Algae Cultivation. .
ELSA
2020 | Konferenz - Poster | ELSA-ID: 3009
Ifrim GA et al. (2020) Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production. .
ELSA
2020 | Sammelwerk - Beitrag | ELSA-ID: 2397
Hernández Rodríguez T and Frahm B (2020) Design, Optimization and Adaptive Control of Cell Culture Seed Trains. In Pörtner R (ed.), Animal Cell Biotechnology - Methods and Protocols, vol. 2095. Berlin, Heidelberg, New York: Springer, pp. 251–267.
ELSA
| DOI
2019 | Konferenz - Vortrag | ELSA-ID: 2956
Möller J et al. (2019) Workflow for Model-Assisted Design and Scale-up of Biopharmaceutical Production Processes. .
ELSA
2019 | Konferenz - Vortrag | ELSA-ID: 2957
Möller J et al. (2019) Model-Assisted Design of Experiments. .
ELSA
2019 | Konferenz - Vortrag | ELSA-ID: 2958
Ifrim GA et al. (2019) Novel Control Strategy for Microalgae in Photobioreactor. .
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3000
Hernández Rodriguez T et al. (2019) Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating. .
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3001
Hernández Rodriguez T et al. (2019) Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating. .
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3002
Möller J et al. (2019) Model-Assisted Design of Experiments – Software Toolbox. .
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3003
Deppe S et al. (2019) Model-Assisted Design of Experiments for Algae Cultivation. .
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3004
Ifrim GA et al. (2019) Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production. .
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3005
Hernández Rodriguez T et al. (2019) Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating. .
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3006
Ifrim GA et al. (2019) Multivariable Control Strategy for the Photosynthetic Cultures of Microalgae. .
ELSA
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 |

Hernández Rodriguez T et al. (2019) Predicting Industrial‐scale Cell Culture Seed Trains–A Bayesian Framework for Model Fitting and Parameter Estimation, Dealing with Uncertainty in Measurements and Model Parameters, Applied to a Nonlinear Kinetic Cell Culture Model, Using an MCMC Method. Biotechnology and Bioengineering 116, 2944–2959.
ELSA
| DOI
| Download (ext.)
2018 | Konferenz - Vortrag | ELSA-ID: 7935
Hernández Rodriguez T et al. (2018) A Model-Assisted Approach for Design, Optimization and Control of Bioprocesses – a Software Tool for Seed Train Simulation and Optimization. .
ELSA
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
Hernández Rodriguez T et al. (2018) Model-Assisted Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization. BioMed Central.
ELSA
| Dateien verfügbar
| DOI
2018 | Konferenz - Vortrag | ELSA-ID: 2955
Pörtner R et al. (2018) Model-Assisted Design of Process Strategies for Cell Culture Processes. .
ELSA
2018 | Konferenz - Poster | ELSA-ID: 2997
Möller J et al. (2018) Model-Assisted Design and Optimization of Process Strategies. .
ELSA
2018 | Konferenz - Poster | ELSA-ID: 2999
Hernández Rodriguez T et al. (2018) Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses. .
ELSA
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 |

Möller J et al. (2018) Model-Assisted Design of Process Strategies for Cell Culture Processes. American Pharmaceutical Review 3, 39–41.
ELSA
| Download (ext.)
2017 | Konferenz - Vortrag | ELSA-ID: 2920
Hernández Rodriguez T et al. (2017) Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. .
ELSA
2017 | Konferenz - Vortrag | ELSA-ID: 2921
Pörtner R et al. (2017) Model-Assisted Design and Optimization of Biotechnological Processes. .
ELSA
2017 | Konferenz - Vortrag | ELSA-ID: 2950
Hernández Rodriguez T et al. (2017) Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. .
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2994
Hernández Rodriguez T et al. (2017) Influence of Parameter Accuracies in Cell Culture Seed Train Simulations. .
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2995
Hernández Rodriguez T et al. (2017) Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization. .
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2996
Hernández Rodriguez T et al. (2017) Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization. .
ELSA
2016 | Konferenz - Poster | ELSA-ID: 2991
Beshay U et al. (2016) DMA Photobioreactor System – Cultivation at Low Shear Stress and Optional Membrane Aeration. .
ELSA
2016 | Konferenz - Poster | ELSA-ID: 2992
Hernández Rodriguez T et al. (2016) A Software Tool for Biopharmaceutical Seed Train Design and Optimization. .
ELSA
2016 | Konferenz - Poster | ELSA-ID: 2993
Koopmann KS et al. (2016) Simulation of Cell Culture Seed Trains – Investigation of the Influence of Parameter Inaccuracies. .
ELSA
2015 | Konferenzband - Beitrag | ELSA-ID: 2819 |

Hernández Rodriguez T, Pörtner R and Frahm B (2015) Considerations for Cell Passaging in Cell Culture Seed Trains. BioMed Central.
ELSA
| DOI
| Download (ext.)
2015 | Konferenzband - Beitrag | ELSA-ID: 2820 |

Kern S et al. (2015) Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale. BioMed Central.
ELSA
| DOI
| Download (ext.)
2015 | Konferenz - Vortrag | ELSA-ID: 2917
Frahm B et al. (2015) Seed Train Design and Optimization for Animal Cell Suspension Culture. .
ELSA
| Dateien verfügbar
2015 | Konferenz - Vortrag | ELSA-ID: 2919
Frahm B et al. (2015) Seed Train Design and Optimization for Animal Cell Suspension Culture. .
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2985
Hernández Rodriguez T, Pörtner R and Frahm B (2015) Considerations for Cell Passaging in Cell Culture Seed Trains. .
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2986
Kern S et al. (2015) Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale. .
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2987
Hernández Rodriguez T, Pörtner R and Frahm B (2015) A Software Tool for Biopharmaceutical Seed Train Design and Optimization. .
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2988
Hernández Rodriguez T, Pörtner R and Frahm B (2015) Considerations for Cell Passaging in Cell Culture Seed Trains. .
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2990
Kern S et al. (2015) Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale. .
ELSA
2015 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2389
Kern S et al. (2015) Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale. Cytotechnology 68, 1019–1032.
ELSA
| DOI
| Download (ext.)
2014 | Patent | ELSA-ID: 2878
Frahm B and Meier U (2014) Beleuchtung von Disposable Bioreaktoren.
ELSA
2014 | Konferenz - Poster | ELSA-ID: 2984
Drews F et al. (2014) Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche. .
ELSA
2014 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2388
Hahne T et al. (2014) Disposable Algae Cultivation for High-Value Products Using All around LED-Illumination Directly on the Bags. Journal of Algal Biomass Utilization 5, 66–73.
ELSA
2013 | Konferenzband - Beitrag | ELSA-ID: 2817 |

Hernández Rodriguez T, Pörtner R and Frahm B (2013) Seed Train Optimization for Suspension Cell Culture. BioMed Central .
ELSA
| DOI
| Download (ext.)
2013 | Konferenzband - Beitrag | ELSA-ID: 2818 |

Kern S et al. (2013) Model-Based Design of the First Steps of a Seed Train for Cell Culture Processes. BioMed Central.
ELSA
| DOI
| Download (ext.)
2013 | Konferenz - Poster | ELSA-ID: 2980
Kern S et al. (2013) Modellgestützte Auslegung der ersten Schritte eines Seed-Trains für Zellkulturprozesse. .
ELSA
2013 | Konferenz - Poster | ELSA-ID: 2981
Kern S et al. (2013) Model-Based Design of the First Steps of a Seed Train for Cell Culture Processes. .
ELSA
2013 | Konferenz - Poster | ELSA-ID: 2982
Hahne T et al. (2013) Disposable Algenkultivierung für hochpreisige Produkte mittels LED-Rundumbeleuchtung direkt auf den Bags. .
ELSA
2013 | Konferenz - Poster | ELSA-ID: 2983
Hernández Rodriguez T, Pörtner R and Frahm B (2013) Seed Train Optimization for Suspension Cell Culture. .
ELSA
2012 | Konferenzband - Beitrag | ELSA-ID: 2816 |

Frahm B and Brod H (2012) Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA). Dordrecht: Springer.
ELSA
| DOI
| Download (ext.)
2012 | Patent | ELSA-ID: 2877
Brod H and Frahm B (2012) Photobioreaktor Mit Rotatorisch Oszillierenden Lichtquellen.
ELSA
2012 | Konferenz - Vortrag | ELSA-ID: 2918
Van Hecke W et al. (2012) Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor. Vogel Business Media.
ELSA
2012 | Konferenz - Poster | ELSA-ID: 2973
Marzougui R, Pörtner R and Frahm B (2012) Optimierung des Seed trains von Suspensions-Zellkulturen. .
ELSA
2011 | Konferenz - Poster | ELSA-ID: 2972
Van Hecke W et al. (2011) Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor. .
ELSA
2011 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2350
Van Hecke W et al. (2011) A Biocatalytic Cascade Reaction Sensitive to the Gas–Liquid Interface: Modeling and Upscaling in a Dynamic Membrane Aeration Reactor. Journal of Molecular Catalysis B: Enzymatic 68, 154–161.
ELSA
| DOI
| Download (ext.)
2010 | Konferenzband - Beitrag | ELSA-ID: 2815
Dercks B et al. (2010) Intensified Absorption and Distillation Devices for Modular Chemical Production Processes. Czech Society of Chemical Engineering.
ELSA
2010 | Patent | ELSA-ID: 2873
Brod H, Frahm B and Kauling J (2010) Verfahren Zur Reduzierung von Ablagerungen Bei Der Kultivierung von Organismen.
ELSA
2010 | Konferenz - Vortrag | ELSA-ID: 2892
Frahm B and Brod H (2010) Cultivation of Sensitive Cell Lines - Improving Bioreactor Performance by Dynamic Membrane Aeration. .
ELSA
2010 | Konferenz - Vortrag | ELSA-ID: 2913
Dercks B et al. (2010) Intensified Absorption and Distillation Devices for Modular Chemical Production Processes. .
ELSA
2009 | Patent | ELSA-ID: 2872
Braun A et al. (2009) Verfahren Und Vorrichtung Zur Rückhaltung Und Rückführung von Zellen.
ELSA
2009 | Konferenz - Vortrag | ELSA-ID: 2912
Frahm B, Brod H and Langer U (2009) Improving Cell Culture Bioreactor Performance by Dynamic Membrane Aeration (DMA). .
ELSA
2009 | Konferenz - Poster | ELSA-ID: 2970
Frahm B, Brod H and Langer U (2009) Improving Cell Culture Bioreactor Performance by Dynamic Membrane Aeration (DMA). .
ELSA
2009 | Konferenz - Poster | ELSA-ID: 2971
Van Hecke W et al. (2009) Upscaling the Biocatalytic Conversion of Lactose to Lactobionic Acid with the Dynamic Membrane Aeration Reactor. .
ELSA
2009 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2349 |

Frahm B, Brod H and Langer U (2009) Improving Bioreactor Cultivation Conditions for Sensitive Cell Lines by Dynamic Membrane Aeration. Cytotechnology 59, 17–30.
ELSA
| DOI
| Download (ext.)
2008 | Konferenz - Vortrag | ELSA-ID: 2911
Brod H et al. (2008) Pushing the Limits in High-Density Mammalian Cell Fermentation. .
ELSA
2008 | Konferenz - Poster | ELSA-ID: 2968
Frahm B et al. (2008) High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA). .
ELSA
2008 | Konferenz - Poster | ELSA-ID: 2969
Frahm B and Brod H (2008) High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA). .
ELSA
2007 | Patent | ELSA-ID: 2870 |

Brod H et al. (2007) Procedure for Gassing of Liquid for Cell Cultures, Comprises Exchanging of Gas over Immersed Membrane Surfaces and Controlling the Gassing Rate Change of the Gas Concentration and/or Pressure of the Gas or Gas Mixture or Gas Component.
ELSA
| Download (ext.)
2007 | Patent | ELSA-ID: 2871
Brod H et al. (2007) Verfahren Und Vorrichtung Zur Be- Und Entgasung von Flüssigkeiten, Insbesondere in Der Biotechnologie Und Speziell von Zellkulturen.
ELSA
2007 | Konferenz - Vortrag | ELSA-ID: 2909
Brod H, Frahm B and Kauling J (2007) Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. .
ELSA
2007 | Konferenz - Vortrag | ELSA-ID: 2910
Brod H, Frahm B and Kauling J (2007) Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. .
ELSA
2007 | Konferenz - Poster | ELSA-ID: 2967
Frahm B et al. (2007) High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA). .
ELSA
2007 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2348
Frahm B et al. (2007) Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien. Chemie Ingenieur Technik 79, 1052–1058.
ELSA
| DOI
| Download (ext.)
2005 | Konferenz - Vortrag | ELSA-ID: 2907
Pörtner R et al. (2005) Optimisation of Time-Space-Yield for Hybridoma Fed-Batch Cultures with an Adaptive OLFO-Controller. .
ELSA
2005 | Konferenz - Vortrag | ELSA-ID: 2908
Pörtner R et al. (2005) Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. .
ELSA
2005 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2347 |

Frahm B et al. (2005) Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. Chemie Ingenieur Technik 77, 429–435.
ELSA
| DOI
| Download (ext.)
2004 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2345 |

Pörtner R, Schwabe J-O and Frahm B (2004) Evaluation of Selected Control Strategies for Fed-Batch Cultures of a Hybridoma Cell Line. Biotechnology and Applied Biochemistry 40.
ELSA
| DOI
| Download (ext.)
2003 | Konferenz - Vortrag | ELSA-ID: 7934
Frahm B and Pörtner R (2003) Fed-Batch-Cultivation of Animal Cells: Model-Based, Adaptive Control in Comparison to Alternative Control Strategies. .
ELSA
2003 | Konferenzband - Beitrag | ELSA-ID: 2435
Frahm B et al. (2003) Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control, Beckmann D and Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld) (eds). Heiligenstadt: Inst. für Bioprozess- und Analysenmesstechnik .
ELSA
2003 | Konferenzband - Beitrag | ELSA-ID: 2436
Kühn K et al. (2003) Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells, European Federation of Chemical Engineering (ed.). Granada: ECCE4.
ELSA
2003 | Konferenz - Vortrag | ELSA-ID: 2902
Frahm B and Pörtner R (2003) Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung. .
ELSA
2003 | Konferenz - Vortrag | ELSA-ID: 2903
Hass VC et al. (2003) Ein strukturiertes Kompartiment-Modell zur Beschreibung der Kultivierung von Hybridomazellen als Teil einer adaptiven, modellgestützten Prozessführung. .
ELSA
2003 | Konferenz - Vortrag | ELSA-ID: 2905
Frahm B et al. (2003) Fed-Batch-Cultivation of Animal Cells: Model-Based, Adaptive Control in Comparison to Alternative Control Strategies. .
ELSA
| Dateien verfügbar
2003 | Konferenz - Vortrag | ELSA-ID: 2906
Pörtner R et al. (2003) Fed-Batch-Kultivierung tierischer Zellen – eine Herausforderung für eine adaptive, modellgestützte Steuerung. .
ELSA
2003 | Konferenz - Poster | ELSA-ID: 2964
Frahm B and Pörtner R (2003) CO2-off-Gas Measurement for Animal Cell Culture Processes. .
ELSA
2003 | Konferenz - Poster | ELSA-ID: 2965
Frahm B and Pörtner R (2003) Flexible Fed-Batch Process Control of Animal Cells. .
ELSA
2003 | Konferenz - Poster | ELSA-ID: 2966
Kühn K et al. (2003) Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells. .
ELSA
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2343 |

Frahm B et al. (2003) Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung. Chemie Ingenieur Technik 75, 457–460.
ELSA
| DOI
| Download (ext.)
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2344 |

Frahm B et al. (2003) Improvement of a Mammalian Cell Culture Process by Adaptive, Model-Based Dialysis Fed-Batch Cultivation and Suppression of Apoptosis. Bioprocess and Biosystems Engineering 26, 1–10.
ELSA
| DOI
| Download (ext.)
2003 | Dissertation | ELSA-ID: 2393
Frahm B (2003) Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Norderstedt: Books on Demand GmbH.
ELSA
2002 | Konferenzband - Beitrag | ELSA-ID: 2431
Frahm B and Pörtner R (2002) Messung Und Simulation Des Kohlendioxidausstoßes von Zellkulturprozessen, Kaden H and Forum Innovative Biosystemtechnik - Sensorik, Aktorik und Auswertung Biotechnologischer Prozesse (2001 : Waldheim) (eds). Meinsberg : Kurt-Schwabe-Inst. .
ELSA
2002 | Konferenz - Vortrag | ELSA-ID: 2897
Frahm B and Pörtner R (2002) Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen. .
ELSA
2002 | Konferenz - Vortrag | ELSA-ID: 2898
Frahm B and Pörtner R (2002) Adaptive, Model-Based Control by the OLFO-Controller for the Fed-Batch Cultivation of Animal Cells. .
ELSA
2002 | Konferenz - Vortrag | ELSA-ID: 2899
Frahm B and Pörtner R (2002) Adaptive, Model-Based Control by the OLFO-Controller for the Fed-Batch Cultivation of Animal Cells. .
ELSA
2002 | Konferenz - Vortrag | ELSA-ID: 2900
Frahm B et al. (2002) Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control. .
ELSA
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2340 |

Frahm B et al. (2002) Determination of Dissolved CO2 Concentration and CO2 Production Rate of Mammalian Cell Suspension Culture Based on Off-Gas Measurement. Journal of Biotechnology 99, 133–148.
ELSA
| DOI
| Download (ext.)
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2341 |

Frahm B et al. (2002) Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Effective Fed-Batch Cultivation of Hybridoma Cells. Biotechnology Progress 18, 1095–1103.
ELSA
| DOI
| Download (ext.)
2002 | Zeitschriftenaufsatz | ELSA-ID: 2342
Frahm B and Pörtner R (2002) Reaktor-Abgasmessungen bei Zellkulturen. BIOforum 4, 179–180.
ELSA
2001 | Konferenz - Vortrag | ELSA-ID: 7933
Frahm B and Pörtner R (2001) Messung Und Simulation Des Kohlendioxidausstoßes von Zellkulturprozessen. .
ELSA
2001 | Konferenz - Poster | ELSA-ID: 2429
Hass VC et al. (2001) Model-Based Control of Hybridoma Cell Cultures. .
ELSA
2001 | Konferenz - Vortrag | ELSA-ID: 2894
Hoffmann M et al. (2001) Untersuchung verschiedener mathematischer Modelle in Hinblick auf ihre Eignung für die adaptive Prozessführung von Hybridoma Zellkulturen. .
ELSA
2001 | Konferenz - Vortrag | ELSA-ID: 2895
Frahm B and Pörtner R (2001) Arbeitsschwerpunkte TUHH, Bioprozess- und Bioverfahrenstechnik, Arbeitsgruppe Zellkulturtechnik. .
ELSA
2001 | Konferenz - Poster | ELSA-ID: 2960
Frahm B et al. (2001) Adaptive Modellgestützte Steuerung von Zellkulturprozessen. .
ELSA
2001 | Konferenz - Poster | ELSA-ID: 2961
Lane P et al. (2001) Design of Feeding Strategies for Fed-Batch Cultures of Animal Cells by the Method of Inequalities. .
ELSA
2001 | Konferenz - Poster | ELSA-ID: 2962
Frahm B et al. (2001) Development of an Automated, Model-Based, Adaptive Control for the Effective Cultivation of Hybridoma Cells. .
ELSA
2001 | Konferenzband - Beitrag | ELSA-ID: 2963 |

Hass VC et al. (2001) Model-Based Control of Hybridoma Cell Cultures, Published for the International Federation of Automatic Control by Pergamon (ed.). Oxford: ScienceDirect.
ELSA
| DOI
| Download (ext.)
2000 | Konferenz - Vortrag | ELSA-ID: 2893
Anderelei T, Frahm B and Büchs J (2000) Online-Bestimmung der Sauerstofftransferrate (OTR) und der Kohlendioxidtransferrate (CTR) in geschüttelten Bioreaktoren. .
ELSA
2000 | Konferenz - Poster | ELSA-ID: 2959
Hoffmann M et al. (2000) Modellgestützte Prozessführung Für Hybridoma-Kulturen Mit Hilfe Des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus. .
ELSA
Suche
Publikationen filtern
Darstellung / Sortierung
Export / Einbettung
168 Publikationen
2024 | Konferenz - Vortrag | ELSA-ID: 12021
Segermann J et al. (2024) Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie. .
ELSA
2024 | Konferenz - Vortrag | ELSA-ID: 12022
Luttmann M et al. (2024) Erkenntnisse zur Nutzung von Photogrammmetrie für die Untersuchung des Bräunungsverhaltens von Weizenbrötchen. .
ELSA
2024 | Konferenz - Poster | ELSA-ID: 12395
Müller C et al. (2024) Investigation of Microbial Spoilage in Vegan Foods. .
ELSA
2024 | Konferenz - Poster | ELSA-ID: 12396
Gassenmeier V, Campolongo G and Frahm B (2024) Dissolved Carbon Dioxide in Addition to Dissolved Oxygen for In-Situ Monitoring of Hybridoma Cell Culture. .
ELSA
2024 | Konferenz - Poster | ELSA-ID: 12397
Blome A et al. (2024) Process Optimization in Baked Goods Production Using Inline Sensors and Objective Product Evaluation. .
ELSA
2024 | Preprint | ELSA-ID: 12400 |

Ramm S et al. (2024) Semi-Automated vs. Manual: Comparative Study of Cell Culture Counting Methods Using Validation Parameters.
ELSA
| DOI
| Download (ext.)
2024 | Konferenz - Poster | ELSA-ID: 10957
Reinhardt L et al. (n.d.) Mycelium-Based Materials from Residues of the Regional Wood Industry. .
ELSA
2023 | Konferenz - Poster | ELSA-ID: 11378
Gassenmeier V, Campolongo G and Frahm B (n.d.) Real-Time Monitoring of DCO2 in Addition to DO. .
ELSA
2023 | Konferenz - Poster | ELSA-ID: 11381
Hernández Rodriguez T et al. (n.d.) A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. DECHEMA e.V.
ELSA
2023 | Konferenz - Poster | ELSA-ID: 11382 |

Gassenmeier V et al. (n.d.) View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks. .
ELSA
| Download (ext.)
2023 | Konferenz - Vortrag | ELSA-ID: 11383
Hernández Rodriguez T et al. (2023) Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture. DECHEMA e.V.
ELSA
2023 | Konferenzband - Beitrag | ELSA-ID: 11384 |

Müller C et al. (2023) Microbial Spoilage in Vegan Foods. Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draženka Komes, Sanja Vidaček Filipec and Bojana Voučko.
ELSA
| Download (ext.)
2023 | Konferenz - Poster | ELSA-ID: 11487 |

Ramm S et al. (n.d.) Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression . DECHEMA e.V.
ELSA
| Download (ext.)
2023 | Konferenz - Poster | ELSA-ID: 10201 |

Hernández Rodriguez T et al. (2023) A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. .
ELSA
| Download (ext.)
2023 | Konferenz - Vortrag | ELSA-ID: 11109
Blome A et al. (2023) Untersuchung der räumlichen Verteilung von viskoelastischen Kenngrößen während der Weizenteigbereitung. .
ELSA
2023 | Konferenz - Poster | ELSA-ID: 11110
Blome A et al. (2023) Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung. .
ELSA
2023 | Konferenz - Poster | ELSA-ID: 12483
Blome A et al. (2023) Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung. .
ELSA
2023 | Konferenz - Poster | ELSA-ID: 12485
Luttmann M et al. (2023) Teig 4.0 - Promotionsthemen. .
ELSA
2023 | Konferenzband - Beitrag | ELSA-ID: 10788 |

Ramm S et al. (2023) Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, Jasperneite J et al. (eds). [Piscataway, NJ]: IEEE.
ELSA
| DOI
| Download (ext.)
2022 | Konferenz - Poster | ELSA-ID: 7932
Hernández Rodriguez T et al. (n.d.) A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. .
ELSA
2022 | Datenpublikation | ELSA-ID: 10190
Gassenmeier V and Frahm B (2022) Real-Time Monitoring of DCO2 in Addition to DO. assets-labs.
ELSA
| Dateien verfügbar
2022 | Sammelwerk - Beitrag | ELSA-ID: 10193
Hernández Rodriguez T et al. (2022) Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. In Pörtner R and Möller J (eds), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, vol. special issue. Basel: MDPI, pp. 21–48.
ELSA
| DOI
2022 | Konferenzband - Beitrag | ELSA-ID: 10195
Blome A et al. (2022) Process Optimisation in the Field of Wheat Dough Processing Using Real-Time Recording of Quality-Relevant Characteristics in Raw Materials, Intermediates and Final Products. Versuchsanstalt der Hefeindustrie e.V.
ELSA
2022 | Konferenz - Vortrag | ELSA-ID: 10196
Blome A et al. (2022) Process Optimisation in the Field of Wheat Dough Processing Using Real-Time Recording of Quality-Relevant Characteristics in Raw Materials, Intermediates and Final Products. .
ELSA
2022 | Konferenz - Vortrag | ELSA-ID: 10197
Hernández Rodriguez T et al. (2022) Model Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture. .
ELSA
2022 | Konferenz - Poster | ELSA-ID: 10198
Hernández Rodriguez T et al. (n.d.) A Systematic, Model-Based Approach for Decision Making in Upstream Development – Considerations Regarding Clone Selection and Cell Expansion. .
ELSA
2022 | Konferenz - Poster | ELSA-ID: 10199 |

Müller C et al. (2022) Microbial Spoilage in Vegan Foods. .
ELSA
| Download (ext.)
2021 | Konferenz - Vortrag | ELSA-ID: 7927
Hernández Rodriguez T and Frahm B (2021) Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction. .
ELSA
2021 | Konferenz - Poster | ELSA-ID: 7931
Moser A et al. (2021) Model-Assisted Design of Experiments - Concept, Software and Applications. .
ELSA
2021 | Lexikoneintrag | ELSA-ID: 7939
Wirtanen G et al. (2021) Bovine Colostrum for Human Consumption. MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science.
ELSA
2021 | Sammelwerk - Beitrag | ELSA-ID: 7983
Hernández Rodriguez T et al. (2021) Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection – a Simulation Study. Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, vol. special issue. Basel: MDPI, pp. 49–74.
ELSA
| DOI
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
Hernández Rodriguez T et al. (2021) Dynamic Parameter Estimation and Prediction over Consecutive Scales, Based on Moving Horizon Estimation - Applied to an Industrial Cell Culture Seed Train. Bioprocess and Biosystems Engineering 44, 793–808.
ELSA
| DOI
2021 | Konferenz - Vortrag | ELSA-ID: 8078
Blome A et al. (2021) Messtechnikkonzepte Für Die Erfassung von Qualitätsrelevanten Parametern Und Merkmalen Bei Der Weizenteigverarbeitung. .
ELSA
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
Hernández Rodriguez T and Frahm B (2021) Digital Seed Train Twins and Statistical Methods. In Herwig C, Pörtner R and Möller J (eds), Digital Twins Tools and Concepts for Smart Biomanufacturing, vol. 176. Berlin, Heidelberg: Springer, pp. 97–131.
ELSA
| DOI
2020 | Konferenz - Poster | ELSA-ID: 7929
Hernández Rodriguez T et al. (2020) Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration. .
ELSA
2020 | Konferenz - Poster | ELSA-ID: 7930
Hernández Rodriguez T et al. (2020) Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes. .
ELSA
2020 | Konferenz - Vortrag | ELSA-ID: 7936
Hernández Rodriguez T, Frahm B and Posch C (2020) Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support. .
ELSA
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
Hernández Rodriguez T et al. (2020) Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach. BioMed Central.
ELSA
| Dateien verfügbar
| DOI
2020 | Konferenz - Poster | ELSA-ID: 3007
Kuhfuß F et al. (2020) Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration. .
ELSA
2020 | Konferenz - Poster | ELSA-ID: 3008
Deppe S et al. (2020) Model-Assisted Design of Experiments for Algae Cultivation. .
ELSA
2020 | Konferenz - Poster | ELSA-ID: 3009
Ifrim GA et al. (2020) Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production. .
ELSA
2020 | Sammelwerk - Beitrag | ELSA-ID: 2397
Hernández Rodríguez T and Frahm B (2020) Design, Optimization and Adaptive Control of Cell Culture Seed Trains. In Pörtner R (ed.), Animal Cell Biotechnology - Methods and Protocols, vol. 2095. Berlin, Heidelberg, New York: Springer, pp. 251–267.
ELSA
| DOI
2019 | Konferenz - Vortrag | ELSA-ID: 2956
Möller J et al. (2019) Workflow for Model-Assisted Design and Scale-up of Biopharmaceutical Production Processes. .
ELSA
2019 | Konferenz - Vortrag | ELSA-ID: 2957
Möller J et al. (2019) Model-Assisted Design of Experiments. .
ELSA
2019 | Konferenz - Vortrag | ELSA-ID: 2958
Ifrim GA et al. (2019) Novel Control Strategy for Microalgae in Photobioreactor. .
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3000
Hernández Rodriguez T et al. (2019) Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating. .
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3001
Hernández Rodriguez T et al. (2019) Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating. .
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3002
Möller J et al. (2019) Model-Assisted Design of Experiments – Software Toolbox. .
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3003
Deppe S et al. (2019) Model-Assisted Design of Experiments for Algae Cultivation. .
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3004
Ifrim GA et al. (2019) Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production. .
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3005
Hernández Rodriguez T et al. (2019) Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating. .
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3006
Ifrim GA et al. (2019) Multivariable Control Strategy for the Photosynthetic Cultures of Microalgae. .
ELSA
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 |

Hernández Rodriguez T et al. (2019) Predicting Industrial‐scale Cell Culture Seed Trains–A Bayesian Framework for Model Fitting and Parameter Estimation, Dealing with Uncertainty in Measurements and Model Parameters, Applied to a Nonlinear Kinetic Cell Culture Model, Using an MCMC Method. Biotechnology and Bioengineering 116, 2944–2959.
ELSA
| DOI
| Download (ext.)
2018 | Konferenz - Vortrag | ELSA-ID: 7935
Hernández Rodriguez T et al. (2018) A Model-Assisted Approach for Design, Optimization and Control of Bioprocesses – a Software Tool for Seed Train Simulation and Optimization. .
ELSA
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
Hernández Rodriguez T et al. (2018) Model-Assisted Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization. BioMed Central.
ELSA
| Dateien verfügbar
| DOI
2018 | Konferenz - Vortrag | ELSA-ID: 2955
Pörtner R et al. (2018) Model-Assisted Design of Process Strategies for Cell Culture Processes. .
ELSA
2018 | Konferenz - Poster | ELSA-ID: 2997
Möller J et al. (2018) Model-Assisted Design and Optimization of Process Strategies. .
ELSA
2018 | Konferenz - Poster | ELSA-ID: 2999
Hernández Rodriguez T et al. (2018) Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses. .
ELSA
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 |

Möller J et al. (2018) Model-Assisted Design of Process Strategies for Cell Culture Processes. American Pharmaceutical Review 3, 39–41.
ELSA
| Download (ext.)
2017 | Konferenz - Vortrag | ELSA-ID: 2920
Hernández Rodriguez T et al. (2017) Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. .
ELSA
2017 | Konferenz - Vortrag | ELSA-ID: 2921
Pörtner R et al. (2017) Model-Assisted Design and Optimization of Biotechnological Processes. .
ELSA
2017 | Konferenz - Vortrag | ELSA-ID: 2950
Hernández Rodriguez T et al. (2017) Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. .
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2994
Hernández Rodriguez T et al. (2017) Influence of Parameter Accuracies in Cell Culture Seed Train Simulations. .
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2995
Hernández Rodriguez T et al. (2017) Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization. .
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2996
Hernández Rodriguez T et al. (2017) Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization. .
ELSA
2016 | Konferenz - Poster | ELSA-ID: 2991
Beshay U et al. (2016) DMA Photobioreactor System – Cultivation at Low Shear Stress and Optional Membrane Aeration. .
ELSA
2016 | Konferenz - Poster | ELSA-ID: 2992
Hernández Rodriguez T et al. (2016) A Software Tool for Biopharmaceutical Seed Train Design and Optimization. .
ELSA
2016 | Konferenz - Poster | ELSA-ID: 2993
Koopmann KS et al. (2016) Simulation of Cell Culture Seed Trains – Investigation of the Influence of Parameter Inaccuracies. .
ELSA
2015 | Konferenzband - Beitrag | ELSA-ID: 2819 |

Hernández Rodriguez T, Pörtner R and Frahm B (2015) Considerations for Cell Passaging in Cell Culture Seed Trains. BioMed Central.
ELSA
| DOI
| Download (ext.)
2015 | Konferenzband - Beitrag | ELSA-ID: 2820 |

Kern S et al. (2015) Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale. BioMed Central.
ELSA
| DOI
| Download (ext.)
2015 | Konferenz - Vortrag | ELSA-ID: 2917
Frahm B et al. (2015) Seed Train Design and Optimization for Animal Cell Suspension Culture. .
ELSA
| Dateien verfügbar
2015 | Konferenz - Vortrag | ELSA-ID: 2919
Frahm B et al. (2015) Seed Train Design and Optimization for Animal Cell Suspension Culture. .
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2985
Hernández Rodriguez T, Pörtner R and Frahm B (2015) Considerations for Cell Passaging in Cell Culture Seed Trains. .
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2986
Kern S et al. (2015) Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale. .
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2987
Hernández Rodriguez T, Pörtner R and Frahm B (2015) A Software Tool for Biopharmaceutical Seed Train Design and Optimization. .
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2988
Hernández Rodriguez T, Pörtner R and Frahm B (2015) Considerations for Cell Passaging in Cell Culture Seed Trains. .
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2990
Kern S et al. (2015) Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale. .
ELSA
2015 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2389
Kern S et al. (2015) Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale. Cytotechnology 68, 1019–1032.
ELSA
| DOI
| Download (ext.)
2014 | Patent | ELSA-ID: 2878
Frahm B and Meier U (2014) Beleuchtung von Disposable Bioreaktoren.
ELSA
2014 | Konferenz - Poster | ELSA-ID: 2984
Drews F et al. (2014) Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche. .
ELSA
2014 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2388
Hahne T et al. (2014) Disposable Algae Cultivation for High-Value Products Using All around LED-Illumination Directly on the Bags. Journal of Algal Biomass Utilization 5, 66–73.
ELSA
2013 | Konferenzband - Beitrag | ELSA-ID: 2817 |

Hernández Rodriguez T, Pörtner R and Frahm B (2013) Seed Train Optimization for Suspension Cell Culture. BioMed Central .
ELSA
| DOI
| Download (ext.)
2013 | Konferenzband - Beitrag | ELSA-ID: 2818 |

Kern S et al. (2013) Model-Based Design of the First Steps of a Seed Train for Cell Culture Processes. BioMed Central.
ELSA
| DOI
| Download (ext.)
2013 | Konferenz - Poster | ELSA-ID: 2980
Kern S et al. (2013) Modellgestützte Auslegung der ersten Schritte eines Seed-Trains für Zellkulturprozesse. .
ELSA
2013 | Konferenz - Poster | ELSA-ID: 2981
Kern S et al. (2013) Model-Based Design of the First Steps of a Seed Train for Cell Culture Processes. .
ELSA
2013 | Konferenz - Poster | ELSA-ID: 2982
Hahne T et al. (2013) Disposable Algenkultivierung für hochpreisige Produkte mittels LED-Rundumbeleuchtung direkt auf den Bags. .
ELSA
2013 | Konferenz - Poster | ELSA-ID: 2983
Hernández Rodriguez T, Pörtner R and Frahm B (2013) Seed Train Optimization for Suspension Cell Culture. .
ELSA
2012 | Konferenzband - Beitrag | ELSA-ID: 2816 |

Frahm B and Brod H (2012) Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA). Dordrecht: Springer.
ELSA
| DOI
| Download (ext.)
2012 | Patent | ELSA-ID: 2877
Brod H and Frahm B (2012) Photobioreaktor Mit Rotatorisch Oszillierenden Lichtquellen.
ELSA
2012 | Konferenz - Vortrag | ELSA-ID: 2918
Van Hecke W et al. (2012) Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor. Vogel Business Media.
ELSA
2012 | Konferenz - Poster | ELSA-ID: 2973
Marzougui R, Pörtner R and Frahm B (2012) Optimierung des Seed trains von Suspensions-Zellkulturen. .
ELSA
2011 | Konferenz - Poster | ELSA-ID: 2972
Van Hecke W et al. (2011) Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor. .
ELSA
2011 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2350
Van Hecke W et al. (2011) A Biocatalytic Cascade Reaction Sensitive to the Gas–Liquid Interface: Modeling and Upscaling in a Dynamic Membrane Aeration Reactor. Journal of Molecular Catalysis B: Enzymatic 68, 154–161.
ELSA
| DOI
| Download (ext.)
2010 | Konferenzband - Beitrag | ELSA-ID: 2815
Dercks B et al. (2010) Intensified Absorption and Distillation Devices for Modular Chemical Production Processes. Czech Society of Chemical Engineering.
ELSA
2010 | Patent | ELSA-ID: 2873
Brod H, Frahm B and Kauling J (2010) Verfahren Zur Reduzierung von Ablagerungen Bei Der Kultivierung von Organismen.
ELSA
2010 | Konferenz - Vortrag | ELSA-ID: 2892
Frahm B and Brod H (2010) Cultivation of Sensitive Cell Lines - Improving Bioreactor Performance by Dynamic Membrane Aeration. .
ELSA
2010 | Konferenz - Vortrag | ELSA-ID: 2913
Dercks B et al. (2010) Intensified Absorption and Distillation Devices for Modular Chemical Production Processes. .
ELSA
2009 | Patent | ELSA-ID: 2872
Braun A et al. (2009) Verfahren Und Vorrichtung Zur Rückhaltung Und Rückführung von Zellen.
ELSA
2009 | Konferenz - Vortrag | ELSA-ID: 2912
Frahm B, Brod H and Langer U (2009) Improving Cell Culture Bioreactor Performance by Dynamic Membrane Aeration (DMA). .
ELSA
2009 | Konferenz - Poster | ELSA-ID: 2970
Frahm B, Brod H and Langer U (2009) Improving Cell Culture Bioreactor Performance by Dynamic Membrane Aeration (DMA). .
ELSA
2009 | Konferenz - Poster | ELSA-ID: 2971
Van Hecke W et al. (2009) Upscaling the Biocatalytic Conversion of Lactose to Lactobionic Acid with the Dynamic Membrane Aeration Reactor. .
ELSA
2009 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2349 |

Frahm B, Brod H and Langer U (2009) Improving Bioreactor Cultivation Conditions for Sensitive Cell Lines by Dynamic Membrane Aeration. Cytotechnology 59, 17–30.
ELSA
| DOI
| Download (ext.)
2008 | Konferenz - Vortrag | ELSA-ID: 2911
Brod H et al. (2008) Pushing the Limits in High-Density Mammalian Cell Fermentation. .
ELSA
2008 | Konferenz - Poster | ELSA-ID: 2968
Frahm B et al. (2008) High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA). .
ELSA
2008 | Konferenz - Poster | ELSA-ID: 2969
Frahm B and Brod H (2008) High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA). .
ELSA
2007 | Patent | ELSA-ID: 2870 |

Brod H et al. (2007) Procedure for Gassing of Liquid for Cell Cultures, Comprises Exchanging of Gas over Immersed Membrane Surfaces and Controlling the Gassing Rate Change of the Gas Concentration and/or Pressure of the Gas or Gas Mixture or Gas Component.
ELSA
| Download (ext.)
2007 | Patent | ELSA-ID: 2871
Brod H et al. (2007) Verfahren Und Vorrichtung Zur Be- Und Entgasung von Flüssigkeiten, Insbesondere in Der Biotechnologie Und Speziell von Zellkulturen.
ELSA
2007 | Konferenz - Vortrag | ELSA-ID: 2909
Brod H, Frahm B and Kauling J (2007) Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. .
ELSA
2007 | Konferenz - Vortrag | ELSA-ID: 2910
Brod H, Frahm B and Kauling J (2007) Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. .
ELSA
2007 | Konferenz - Poster | ELSA-ID: 2967
Frahm B et al. (2007) High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA). .
ELSA
2007 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2348
Frahm B et al. (2007) Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien. Chemie Ingenieur Technik 79, 1052–1058.
ELSA
| DOI
| Download (ext.)
2005 | Konferenz - Vortrag | ELSA-ID: 2907
Pörtner R et al. (2005) Optimisation of Time-Space-Yield for Hybridoma Fed-Batch Cultures with an Adaptive OLFO-Controller. .
ELSA
2005 | Konferenz - Vortrag | ELSA-ID: 2908
Pörtner R et al. (2005) Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. .
ELSA
2005 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2347 |

Frahm B et al. (2005) Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. Chemie Ingenieur Technik 77, 429–435.
ELSA
| DOI
| Download (ext.)
2004 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2345 |

Pörtner R, Schwabe J-O and Frahm B (2004) Evaluation of Selected Control Strategies for Fed-Batch Cultures of a Hybridoma Cell Line. Biotechnology and Applied Biochemistry 40.
ELSA
| DOI
| Download (ext.)
2003 | Konferenz - Vortrag | ELSA-ID: 7934
Frahm B and Pörtner R (2003) Fed-Batch-Cultivation of Animal Cells: Model-Based, Adaptive Control in Comparison to Alternative Control Strategies. .
ELSA
2003 | Konferenzband - Beitrag | ELSA-ID: 2435
Frahm B et al. (2003) Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control, Beckmann D and Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld) (eds). Heiligenstadt: Inst. für Bioprozess- und Analysenmesstechnik .
ELSA
2003 | Konferenzband - Beitrag | ELSA-ID: 2436
Kühn K et al. (2003) Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells, European Federation of Chemical Engineering (ed.). Granada: ECCE4.
ELSA
2003 | Konferenz - Vortrag | ELSA-ID: 2902
Frahm B and Pörtner R (2003) Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung. .
ELSA
2003 | Konferenz - Vortrag | ELSA-ID: 2903
Hass VC et al. (2003) Ein strukturiertes Kompartiment-Modell zur Beschreibung der Kultivierung von Hybridomazellen als Teil einer adaptiven, modellgestützten Prozessführung. .
ELSA
2003 | Konferenz - Vortrag | ELSA-ID: 2905
Frahm B et al. (2003) Fed-Batch-Cultivation of Animal Cells: Model-Based, Adaptive Control in Comparison to Alternative Control Strategies. .
ELSA
| Dateien verfügbar
2003 | Konferenz - Vortrag | ELSA-ID: 2906
Pörtner R et al. (2003) Fed-Batch-Kultivierung tierischer Zellen – eine Herausforderung für eine adaptive, modellgestützte Steuerung. .
ELSA
2003 | Konferenz - Poster | ELSA-ID: 2964
Frahm B and Pörtner R (2003) CO2-off-Gas Measurement for Animal Cell Culture Processes. .
ELSA
2003 | Konferenz - Poster | ELSA-ID: 2965
Frahm B and Pörtner R (2003) Flexible Fed-Batch Process Control of Animal Cells. .
ELSA
2003 | Konferenz - Poster | ELSA-ID: 2966
Kühn K et al. (2003) Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells. .
ELSA
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2343 |

Frahm B et al. (2003) Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung. Chemie Ingenieur Technik 75, 457–460.
ELSA
| DOI
| Download (ext.)
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2344 |

Frahm B et al. (2003) Improvement of a Mammalian Cell Culture Process by Adaptive, Model-Based Dialysis Fed-Batch Cultivation and Suppression of Apoptosis. Bioprocess and Biosystems Engineering 26, 1–10.
ELSA
| DOI
| Download (ext.)
2003 | Dissertation | ELSA-ID: 2393
Frahm B (2003) Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Norderstedt: Books on Demand GmbH.
ELSA
2002 | Konferenzband - Beitrag | ELSA-ID: 2431
Frahm B and Pörtner R (2002) Messung Und Simulation Des Kohlendioxidausstoßes von Zellkulturprozessen, Kaden H and Forum Innovative Biosystemtechnik - Sensorik, Aktorik und Auswertung Biotechnologischer Prozesse (2001 : Waldheim) (eds). Meinsberg : Kurt-Schwabe-Inst. .
ELSA
2002 | Konferenz - Vortrag | ELSA-ID: 2897
Frahm B and Pörtner R (2002) Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen. .
ELSA
2002 | Konferenz - Vortrag | ELSA-ID: 2898
Frahm B and Pörtner R (2002) Adaptive, Model-Based Control by the OLFO-Controller for the Fed-Batch Cultivation of Animal Cells. .
ELSA
2002 | Konferenz - Vortrag | ELSA-ID: 2899
Frahm B and Pörtner R (2002) Adaptive, Model-Based Control by the OLFO-Controller for the Fed-Batch Cultivation of Animal Cells. .
ELSA
2002 | Konferenz - Vortrag | ELSA-ID: 2900
Frahm B et al. (2002) Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control. .
ELSA
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2340 |

Frahm B et al. (2002) Determination of Dissolved CO2 Concentration and CO2 Production Rate of Mammalian Cell Suspension Culture Based on Off-Gas Measurement. Journal of Biotechnology 99, 133–148.
ELSA
| DOI
| Download (ext.)
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2341 |

Frahm B et al. (2002) Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Effective Fed-Batch Cultivation of Hybridoma Cells. Biotechnology Progress 18, 1095–1103.
ELSA
| DOI
| Download (ext.)
2002 | Zeitschriftenaufsatz | ELSA-ID: 2342
Frahm B and Pörtner R (2002) Reaktor-Abgasmessungen bei Zellkulturen. BIOforum 4, 179–180.
ELSA
2001 | Konferenz - Vortrag | ELSA-ID: 7933
Frahm B and Pörtner R (2001) Messung Und Simulation Des Kohlendioxidausstoßes von Zellkulturprozessen. .
ELSA
2001 | Konferenz - Poster | ELSA-ID: 2429
Hass VC et al. (2001) Model-Based Control of Hybridoma Cell Cultures. .
ELSA
2001 | Konferenz - Vortrag | ELSA-ID: 2894
Hoffmann M et al. (2001) Untersuchung verschiedener mathematischer Modelle in Hinblick auf ihre Eignung für die adaptive Prozessführung von Hybridoma Zellkulturen. .
ELSA
2001 | Konferenz - Vortrag | ELSA-ID: 2895
Frahm B and Pörtner R (2001) Arbeitsschwerpunkte TUHH, Bioprozess- und Bioverfahrenstechnik, Arbeitsgruppe Zellkulturtechnik. .
ELSA
2001 | Konferenz - Poster | ELSA-ID: 2960
Frahm B et al. (2001) Adaptive Modellgestützte Steuerung von Zellkulturprozessen. .
ELSA
2001 | Konferenz - Poster | ELSA-ID: 2961
Lane P et al. (2001) Design of Feeding Strategies for Fed-Batch Cultures of Animal Cells by the Method of Inequalities. .
ELSA
2001 | Konferenz - Poster | ELSA-ID: 2962
Frahm B et al. (2001) Development of an Automated, Model-Based, Adaptive Control for the Effective Cultivation of Hybridoma Cells. .
ELSA
2001 | Konferenzband - Beitrag | ELSA-ID: 2963 |

Hass VC et al. (2001) Model-Based Control of Hybridoma Cell Cultures, Published for the International Federation of Automatic Control by Pergamon (ed.). Oxford: ScienceDirect.
ELSA
| DOI
| Download (ext.)
2000 | Konferenz - Vortrag | ELSA-ID: 2893
Anderelei T, Frahm B and Büchs J (2000) Online-Bestimmung der Sauerstofftransferrate (OTR) und der Kohlendioxidtransferrate (CTR) in geschüttelten Bioreaktoren. .
ELSA
2000 | Konferenz - Poster | ELSA-ID: 2959
Hoffmann M et al. (2000) Modellgestützte Prozessführung Für Hybridoma-Kulturen Mit Hilfe Des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus. .
ELSA