Björn Frahm

Fachbereich 4 Life Science Technologies
bjoern.frahm@th-owl.de
ID
45666

168 Publikationen

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[168]
2024 | Konferenz - Vortrag | ELSA-ID: 12021
J. Segermann, M. Luttmann, A. Blome, S. Feldt, S. Sivanesan, C.-A. Holst, V. Lohweg, B. Frahm, U. Müller, Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie, 2024.
ELSA
 
[167]
2024 | Konferenz - Vortrag | ELSA-ID: 12022
M. Luttmann, A. Blome, J. Segermann, M. Jekle, B. Frahm, U. Müller, Erkenntnisse zur Nutzung von Photogrammmetrie für die Untersuchung des Bräunungsverhaltens von Weizenbrötchen, 2024.
ELSA
 
[166]
2024 | Konferenz - Poster | ELSA-ID: 12395
C. Müller, J. Alarinta, B. Frahm, G. Wirtanen, Investigation of microbial spoilage in vegan foods, 2024.
ELSA
 
[165]
2024 | Konferenz - Poster | ELSA-ID: 12396
V. Gassenmeier, G. Campolongo, B. Frahm, Dissolved Carbon Dioxide in Addition to Dissolved Oxygen for In-situ Monitoring of Hybridoma Cell Culture, 2024.
ELSA
 
[164]
2024 | Konferenz - Poster | ELSA-ID: 12397
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Process optimization in baked goods production using inline sensors and objective product evaluation, 2024.
ELSA
 
[163]
2024 | Preprint | ELSA-ID: 12400 | OA
S. Ramm, U. Odefey, B. Frahm, M. Pein-Hackelbusch, Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters, (2024).
ELSA | DOI | Download (ext.)
 
[162]
2024 | Konferenz - Poster | ELSA-ID: 10957
L. Reinhardt, V. Gassenmeier, S. Feldt, S. Plate, M. Tremmel, B. Frahm, M. Stosch, Mycelium-based materials from residues of the regional wood industry, n.d.
ELSA
 
[161]
2024 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 12402
P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator, Chemie Ingenieur Technik. 96 (2024) 528–534.
ELSA | DOI | WoS
 
[160]
2023 | Konferenz - Poster | ELSA-ID: 11378
V. Gassenmeier, G. Campolongo, B. Frahm, Real-time Monitoring of DCO2 in addition to DO, n.d.
ELSA
 
[159]
2023 | Konferenz - Poster | ELSA-ID: 11381
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development, DECHEMA e.V., n.d.
ELSA
 
[158]
2023 | Konferenz - Poster | ELSA-ID: 11382 | OA
V. Gassenmeier, F. Kuhfuß, S. Deppe, G. Ifrim, T. Hernández Rodriguez, B. Frahm, View on a mechanistic model of Chlorella vulgaris in shake flasks, n.d.
ELSA | Download (ext.)
 
[157]
2023 | Konferenz - Vortrag | ELSA-ID: 11383
T. Hernández Rodriguez, C. Posch, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture, DECHEMA e.V., 2023.
ELSA
 
[156]
2023 | Konferenzband - Beitrag | ELSA-ID: 11384 | OA
C. Müller, J. Alarinta, B. Frahm, G. Wirtanen, Microbial spoilage in vegan foods, Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draženka Komes, Sanja Vidaček Filipec and Bojana Voučko, 2023.
ELSA | Download (ext.)
 
[155]
2023 | Konferenz - Poster | ELSA-ID: 11487 | OA
S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression , DECHEMA e.V., n.d.
ELSA | Download (ext.)
 
[154]
2023 | Konferenz - Poster | ELSA-ID: 10201 | OA
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development, 2023.
ELSA | Download (ext.)
 
[153]
2023 | Konferenz - Vortrag | ELSA-ID: 11109
A. Blome, M. Luttmann, M. Jekle, B. Frahm, U. Müller, Untersuchung der räumlichen Verteilung von viskoelastischen Kenngrößen während der Weizenteigbereitung, 2023.
ELSA
 
[152]
2023 | Konferenz - Poster | ELSA-ID: 11110
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung, 2023.
ELSA
 
[151]
2023 | Konferenz - Poster | ELSA-ID: 12483
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung, 2023.
ELSA
 
[150]
2023 | Konferenz - Poster | ELSA-ID: 12485
M. Luttmann, A. Blome, M. Jekle, B. Frahm, U. Müller, Teig 4.0 - Promotionsthemen, 2023.
ELSA
 
[149]
2023 | Konferenzband - Beitrag | ELSA-ID: 10788 | OA
S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, IEEE, [Piscataway, NJ], 2023.
ELSA | DOI | Download (ext.)
 
[148]
2023 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11385
P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations, Chemie Ingenieur Technik. 95 (2023) 1960–1969.
ELSA | DOI | WoS
 
[147]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11377
T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design, Processes. 10 (2022).
ELSA | DOI
 
[146]
2022 | Konferenz - Poster | ELSA-ID: 7932
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development, n.d.
ELSA
 
[145]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7976
V. Gassenmeier, S. Deppe, T. Hernández Rodriguez, F. Kuhfuß, A. Moser, V.C. Hass, K.B. Kuchemüller, R. Pörtner, J. Möller, G.A. Ifrim, B. Frahm, Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology, Current Research in Biotechnology. 4 (2022) 102–119.
ELSA | DOI
 
[144]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7977
F. Kuhfuß, V. Gassenmeier, S. Deppe, G.A. Ifrim, T. Hernández Rodriguez, B. Frahm, View on a mechanistic model of Chlorella vulgaris in incubated shake flasks, Bioprocess and Biosystems Engineering. 45 (2022) 15–30.
ELSA | DOI
 
[143]
2022 | Datenpublikation | ELSA-ID: 10190
V. Gassenmeier, B. Frahm, Real-time Monitoring of DCO2 in addition to DO, assets-labs, 2022.
ELSA | Dateien verfügbar
 
[142]
2022 | Sammelwerk - Beitrag | ELSA-ID: 10193
T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design, in: R. Pörtner, J. Möller (Eds.), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2022: pp. 21–48.
ELSA | DOI
 
[141]
2022 | Konferenzband - Beitrag | ELSA-ID: 10195
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Process optimisation in the field of wheat dough processing using real-time recording of quality-relevant characteristics in raw materials, intermediates and final products, Versuchsanstalt der Hefeindustrie e.V., 2022.
ELSA
 
[140]
2022 | Konferenz - Vortrag | ELSA-ID: 10196
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Process optimisation in the field of wheat dough processing using real-time recording of quality-relevant characteristics in raw materials, intermediates and final products, 2022.
ELSA
 
[139]
2022 | Konferenz - Vortrag | ELSA-ID: 10197
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture, 2022.
ELSA
 
[138]
2022 | Konferenz - Poster | ELSA-ID: 10198
T. Hernández Rodriguez, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion, n.d.
ELSA
 
[137]
2022 | Konferenz - Poster | ELSA-ID: 10199 | OA
C. Müller, J. Alarinta, B. Frahm, G. Wirtanen, Microbial spoilage in vegan foods, 2022.
ELSA | Download (ext.)
 
[136]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11376
T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study, Processes. 9 (2021).
ELSA | DOI
 
[135]
2021 | Konferenz - Vortrag | ELSA-ID: 7927
T. Hernández Rodriguez, B. Frahm, Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction, 2021.
ELSA
 
[134]
2021 | Konferenz - Poster | ELSA-ID: 7931
A. Moser, J. Möller, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, B. Frahm, R. Pörtner, V.C. Hass, Model-assisted Design of Experiments - Concept, Software and Applications, 2021.
ELSA
 
[133]
2021 | Lexikoneintrag | ELSA-ID: 7939
G. Wirtanen, J. Alarinta, B. Frahm, S. Fasse, Bovine Colostrum for Human Consumption, in: MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science, 2021.
ELSA
 
[132]
2021 | Sammelwerk - Beitrag | ELSA-ID: 7983
T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study, in: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2021: pp. 49–74.
ELSA | DOI
 
[131]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train, Bioprocess and Biosystems Engineering. 44 (2021) 793–808.
ELSA | DOI
 
[130]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7986
A. Moser, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, B. Frahm, R. Pörtner, V.C. Hass, J. Möller, Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses, Bioprocess and Biosystems Engineering. 44 (2021) 683–700.
ELSA | DOI
 
[129]
2021 | Konferenz - Vortrag | ELSA-ID: 8078
A. Blome, M. Luttmann, B. Frahm, U. Müller, Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung, 2021.
ELSA
 
[128]
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
T. Hernández Rodriguez, B. Frahm, Digital Seed Train Twins and Statistical Methods, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digital Twins Tools and Concepts for Smart Biomanufacturing, Springer, Berlin, Heidelberg, 2021: pp. 97–131.
ELSA | DOI
 
[127]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7981
S. Fasse, J. Alarinta, B. Frahm, G. Wirtanen, Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing, Dairy. 2 (2021) 556–575.
ELSA | DOI | WoS
 
[126]
2020 | Konferenz - Poster | ELSA-ID: 7929
T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration, 2020.
ELSA
 
[125]
2020 | Konferenz - Poster | ELSA-ID: 7930
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes, 2020.
ELSA
 
[124]
2020 | Konferenz - Vortrag | ELSA-ID: 7936
T. Hernández Rodriguez, B. Frahm, C. Posch, Integration of prior knowledge and digital tools for uncertainty-based decision support, 2020.
ELSA
 
[123]
2020 | Konferenzband - Beitrag | ELSA-ID: 7937
T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration, Wiley, 2020.
ELSA | DOI
 
[122]
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes, Wiley, 2020.
ELSA | DOI
 
[121]
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, Claus Weihs, R. Pörtner, B. Frahm, Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach, BioMed Central, 2020.
ELSA | Dateien verfügbar | DOI
 
[120]
2020 | Konferenz - Poster | ELSA-ID: 3007
F. Kuhfuß, M. Tölle, T. Hernández Rodriguez, V. Gassenmeier, S. Deppe, G.A. Ifrim, B. Frahm, Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration, 2020.
ELSA
 
[119]
2020 | Konferenz - Poster | ELSA-ID: 3008
S. Deppe, F. Kuhfuß, M. Tölle, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, J. Möller, R. Pörtner, A. Moser, V.C. Hass, B. Frahm, Model-assisted Design of Experiments for algae cultivation, 2020.
ELSA
 
[118]
2020 | Konferenz - Poster | ELSA-ID: 3009
G.A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, B. Frahm, Modeling of microalgae in an air-lift photobioreactor for biomass production, 2020.
ELSA
 
[117]
2020 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2392
J. Möller, T. Hernández Rodríguez, J. Müller, L. Arndt, K.B. Kuchemüller, B. Frahm, R. Eibl, D. Eibl, R. Pörtner, Model uncertainty-based evaluation of process strategies during scale-up of biopharmaceutical processes, Computers & Chemical Engineering. 134 (2020) 1–13.
ELSA | DOI
 
[116]
2020 | Sammelwerk - Beitrag | ELSA-ID: 2397
T. Hernández Rodríguez, B. Frahm, Design, Optimization and Adaptive Control of Cell Culture Seed Trains, in: R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols, Springer, Berlin, Heidelberg, New York, 2020: pp. 251–267.
ELSA | DOI
 
[115]
2020 | Sammelwerk - Beitrag | ELSA-ID: 2399
S. Deppe, B. Frahm, V.C. Hass, T. Hernández Rodríguez, K.B. Kuchemüller, J. Möller, R. Pörtner, Estimation of Process Model Parameters, in: R. Pörtner (Ed.), Animal Cell Biotechnology: Methods and Protocols, Springer, Berlin ; Heidelberg ; New York, 2020: pp. 213–234.
ELSA | DOI
 
[114]
2019 | Konferenz - Vortrag | ELSA-ID: 7928
B. Frahm, Scale-up of stirred vessels, 2019.
ELSA
 
[113]
2019 | Konferenz - Vortrag | ELSA-ID: 2956
J. Möller, J. Müller, T. Hernández Rodriguez, K.B. Kuchemüller, L. Arndt, B. Frahm, R. Eibl, D. Eibl, R. Pörtner, Workflow for model-assisted design and scale-up of biopharmaceutical production processes, 2019.
ELSA
 
[112]
2019 | Konferenz - Vortrag | ELSA-ID: 2957
J. Möller, K.B. Kuchemüller, A. Moser, V.C. Hass, T. Hernández Rodriguez, S. Deppe, B. Frahm, R. Pörtner, Model-Assisted Design of Experiments, 2019.
ELSA
 
[111]
2019 | Konferenz - Vortrag | ELSA-ID: 2958
G.A. Ifrim, M. Titica, S. Deppe, B. Frahm, M. Barbu, S. Caraman, Novel control strategy for microalgae in photobioreactor, 2019.
ELSA
 
[110]
2019 | Konferenz - Poster | ELSA-ID: 3000
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019.
ELSA
 
[109]
2019 | Konferenz - Poster | ELSA-ID: 3001
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019.
ELSA
 
[108]
2019 | Konferenz - Poster | ELSA-ID: 3002
J. Möller, K.B. Kuchemüller, T. Hernández Rodriguez, S. Deppe, G.A. Ifrim, A. Moser, V.C. Hass, B. Frahm, R. Pörtner, Model-Assisted Design of Experiments – Software Toolbox, 2019.
ELSA
 
[107]
2019 | Konferenz - Poster | ELSA-ID: 3003
S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, M. Tölle, F. Kuhfuß, J. Möller, K.B. Kuchemüller, R. Pörtner, A. Moser, V.C. Hass, G.A. Ifrim, B. Frahm, Model-assisted Design of Experiments for algae cultivation, 2019.
ELSA
 
[106]
2019 | Konferenz - Poster | ELSA-ID: 3004
G.A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, B. Frahm, Modeling of microalgae in an air-lift photobioreactor for biomass production, 2019.
ELSA
 
[105]
2019 | Konferenz - Poster | ELSA-ID: 3005
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019.
ELSA
 
[104]
2019 | Konferenz - Poster | ELSA-ID: 3006
G.A. Ifrim, M. Titica, S. Deppe, B. Frahm, M. Barbu, S. Caraman, Multivariable control strategy for the photosynthetic cultures of microalgae, 2019.
ELSA
 
[103]
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 | OA
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, C. Weihs, R. Pörtner, B. Frahm, Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method, Biotechnology and Bioengineering. 116 (2019) 2944–2959.
ELSA | DOI | Download (ext.)
 
[102]
2019 | Konferenzband - Beitrag | ELSA-ID: 2400
G.A. Ifrim, M. Titica, S. Deppe, B. Frahm, M. Barbu, S. Caraman, Multivariable control strategy for the photosynthetic cultures of microalgae, IEEE, 2019.
ELSA | DOI
 
[101]
2018 | Konferenz - Vortrag | ELSA-ID: 7935
T. Hernández Rodriguez, B. Frahm, C. Posch, J. Schmutzhard, J. Stettner, A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization, 2018.
ELSA
 
[100]
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
T. Hernández Rodriguez, S. Krull, V.C. Hass, J. Möller, R. Pörtner, B. Frahm, Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization, BioMed Central, 2018.
ELSA | Dateien verfügbar | DOI
 
[99]
2018 | Konferenz - Vortrag | ELSA-ID: 2955
R. Pörtner, J. Möller, B. Frahm, V.C. Hass, Model-Assisted Design of Process Strategies for Cell Culture Processes, 2018.
ELSA
 
[98]
2018 | Konferenz - Poster | ELSA-ID: 2997
J. Möller, K.B. Kuchemüller, F. Freiberger, P. Levermann, T. Hernández Rodriguez, B. Frahm, V.C. Hass, R. Pörtner, Model-Assisted Design and Optimization of Process Strategies, 2018.
ELSA
 
[97]
2018 | Konferenz - Poster | ELSA-ID: 2999
T. Hernández Rodriguez, J. Möller, K.B. Kuchemüller, F. Freiberger, P. Levermann, V.C. Hass, B. Frahm, R. Pörtner, Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses, 2018.
ELSA
 
[96]
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 | OA
J. Möller, K.B. Kuchemüller, T. Hernández Rodriguez, B. Frahm, V.C. Hass, R. Pörtner, Model-Assisted Design of Process Strategies for Cell Culture Processes, American Pharmaceutical Review. 3 (2018) 39–41.
ELSA | Download (ext.)
 
[95]
2017 | Konferenz - Vortrag | ELSA-ID: 2920
T. Hernández Rodriguez, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017.
ELSA
 
[94]
2017 | Konferenz - Vortrag | ELSA-ID: 2921
R. Pörtner, J. Möller, T. Hernández Rodriguez, B. Frahm, V.C. Hass, Model-assisted design and optimization of biotechnological processes, 2017.
ELSA
 
[93]
2017 | Konferenz - Vortrag | ELSA-ID: 2950
T. Hernández Rodriguez, K.S. Koopmann, J. Klaes, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017.
ELSA
 
[92]
2017 | Konferenz - Poster | ELSA-ID: 2994
T. Hernández Rodriguez, K.S. Koopmann, R. Pörtner, B. Frahm, Influence of parameter accuracies in cell culture seed train simulations, 2017.
ELSA
 
[91]
2017 | Konferenz - Poster | ELSA-ID: 2995
T. Hernández Rodriguez, S. Krull, V.C. Hass, J. Möller, R. Pörtner, B. Frahm, Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization, 2017.
ELSA
 
[90]
2017 | Konferenz - Poster | ELSA-ID: 2996
T. Hernández Rodriguez, S. Krull, V.C. Hass, R. Pörtner, B. Frahm, Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization, 2017.
ELSA
 
[89]
2016 | Konferenz - Poster | ELSA-ID: 2991
U. Beshay, S. Feldt, B. Schwarze, P. Wefing, T. Hahne, J. Moschinski, C. Müller, R. Büker, M. Kramer, H. Brod, B. Frahm, DMA Photobioreactor System – Cultivation at low shear stress and optional membrane aeration, 2016.
ELSA
 
[88]
2016 | Konferenz - Poster | ELSA-ID: 2992
T. Hernández Rodriguez, S. Vörtler, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, A software tool for biopharmaceutical seed train design and optimization, 2016.
ELSA
 
[87]
2016 | Konferenz - Poster | ELSA-ID: 2993
K.S. Koopmann, T. Hernández Rodriguez, S. Vörtler, U. Beshay, J. Möller, R. Pörtner, B. Frahm, Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies, 2016.
ELSA
 
[86]
2016 | Sammelwerk - Beitrag | ELSA-ID: 2395
R. Pörtner, O. Platas Barradas, B. Frahm, V.C. Hass, Advanced Process and Control Strategies for Bioreactors, in: Current Developments in Biotechnology and Bioengineering: Bioprocesses, Bioreactors and Controls, Elsevier, Amsterdam, 2016: pp. 463–493.
ELSA | DOI
 
[85]
2015 | Konferenzband - Beitrag | ELSA-ID: 2819 | OA
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for cell passaging in cell culture seed trains, BioMed Central, 2015.
ELSA | DOI | Download (ext.)
 
[84]
2015 | Konferenzband - Beitrag | ELSA-ID: 2820 | OA
S. Kern, O. Platas Barradas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-based strategy for cell culture seed train layout verified at lab scale, BioMed Central, 2015.
ELSA | DOI | Download (ext.)
 
[83]
2015 | Konferenz - Vortrag | ELSA-ID: 2917
B. Frahm, R. Pörtner, S. Kern, T. Hernández Rodriguez, Seed train design and optimization for animal cell suspension culture, 2015.
ELSA | Dateien verfügbar
 
[82]
2015 | Konferenz - Vortrag | ELSA-ID: 2919
B. Frahm, T. Hernández Rodriguez, S. Kern, K.S. Koopmann, U. Beshay, O. Platas-Barradas, R. Pörtner, Seed train design and optimization for animal cell suspension culture, 2015.
ELSA
 
[81]
2015 | Konferenz - Poster | ELSA-ID: 2985
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for cell passaging in cell culture seed trains, 2015.
ELSA
 
[80]
2015 | Konferenz - Poster | ELSA-ID: 2986
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-based strategy for cell culture seed train layout verified at lab scale, 2015.
ELSA
 
[79]
2015 | Konferenz - Poster | ELSA-ID: 2987
T. Hernández Rodriguez, R. Pörtner, B. Frahm, A software tool for biopharmaceutical seed train design and optimization, 2015.
ELSA
 
[78]
2015 | Konferenz - Poster | ELSA-ID: 2988
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for cell passaging in cell culture seed trains, 2015.
ELSA
 
[77]
2015 | Konferenz - Poster | ELSA-ID: 2990
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-based strategy for cell culture seed train layout verified at lab scale, 2015.
ELSA
 
[76]
2015 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2389
S. Kern, O. Platas-Barradas, R. Pörtner, B. Frahm, Model-based strategy for cell culture seed train layout verified at lab scale, Cytotechnology. 68 (2015) 1019–1032.
ELSA | DOI | Download (ext.)
 
[75]
2014 | Patent | ELSA-ID: 2878
B. Frahm, U. Meier, Beleuchtung von disposable Bioreaktoren, (2014).
ELSA
 
[74]
2014 | Konferenz - Poster | ELSA-ID: 2984
F. Drews, G. Drews, C. Folz, G. Platz, T. Gassenmeier, M. Kramer, C. Hundeiker, B. Schwarze, B. Frahm, Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche, 2014.
ELSA
 
[73]
2014 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2388
T. Hahne, B. Schwarze, M. Kramer, B. Frahm, Disposable algae cultivation for high-value products using all around LED-illumination directly on the bags, Journal of Algal Biomass Utilization. 5 (2014) 66–73.
ELSA
 
[72]
2013 | Konferenzband - Beitrag | ELSA-ID: 2817 | OA
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed train optimization for suspension cell culture, BioMed Central , 2013.
ELSA | DOI | Download (ext.)
 
[71]
2013 | Konferenzband - Beitrag | ELSA-ID: 2818 | OA
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-based design of the first steps of a seed train for cell culture processes, BioMed Central, 2013.
ELSA | DOI | Download (ext.)
 
[70]
2013 | Konferenz - Poster | ELSA-ID: 2980
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Modellgestützte Auslegung der ersten Schritte eines Seed-Trains für Zellkulturprozesse, 2013.
ELSA
 
[69]
2013 | Konferenz - Poster | ELSA-ID: 2981
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-based design of the first steps of a seed train for cell culture processes, 2013.
ELSA
 
[68]
2013 | Konferenz - Poster | ELSA-ID: 2982
T. Hahne, B. Schwarze, J. Moschinski, A. Kuttig, M. Kramer, B. Frahm, Disposable Algenkultivierung für hochpreisige Produkte mittels LED-Rundumbeleuchtung direkt auf den Bags, 2013.
ELSA
 
[67]
2013 | Konferenz - Poster | ELSA-ID: 2983
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed train optimization for suspension cell culture, 2013.
ELSA
 
[66]
2013 | Sammelwerk - Beitrag | ELSA-ID: 10214
B. Frahm, Seed Train Optimization for Cell Culture, in: R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols, 3rd ed., Humana Press, Totowa, NJ, 2013: pp. 355–367.
ELSA | DOI
 
[65]
2012 | Konferenzband - Beitrag | ELSA-ID: 2816 | OA
B. Frahm, H. Brod, Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA), Springer, Dordrecht, 2012.
ELSA | DOI | Download (ext.)
 
[64]
2012 | Patent | ELSA-ID: 2877
H. Brod, B. Frahm, Photobioreaktor mit rotatorisch oszillierenden Lichtquellen, (2012).
ELSA
 
[63]
2012 | Konferenz - Vortrag | ELSA-ID: 2918
W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, R. Ludwig, Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor, Vogel Business Media, 2012.
ELSA
 
[62]
2012 | Konferenz - Poster | ELSA-ID: 2973
R. Marzougui, R. Pörtner, B. Frahm, Optimierung des Seed trains von Suspensions-Zellkulturen, 2012.
ELSA
 
[61]
2011 | Patent | ELSA-ID: 2876
H. Brod, B. Frahm, M. Jenne, J. Kauling, F. Schmitt, J. Seletzky, Flüssigkeitsbegaser, (2011).
ELSA
 
[60]
2011 | Konferenz - Poster | ELSA-ID: 2972
W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, R. Ludwig, Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor, 2011.
ELSA
 
[59]
2011 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2350
W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, J. Dewulf, H. Van Langenhove, R. Ludwig, A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor, Journal of Molecular Catalysis B: Enzymatic. 68 (2011) 154–161.
ELSA | DOI | Download (ext.)
 
[58]
2010 | Konferenzband - Beitrag | ELSA-ID: 2815
B. Dercks, B. Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, R. Zecirovic, Intensified absorption and distillation devices for modular chemical production processes, Czech Society of Chemical Engineering, 2010.
ELSA
 
[57]
2010 | Patent | ELSA-ID: 2873
H. Brod, B. Frahm, J. Kauling, Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen, (2010).
ELSA
 
[56]
2010 | Patent | ELSA-ID: 2874
H. Brod, B. Frahm, M. Jenne, J. Kauling, Bioreaktor, (2010).
ELSA
 
[55]
2010 | Patent | ELSA-ID: 2875
B. Frahm, J. Kauling, A. Pütz, M. Schindler, Begasungssystem, (2010).
ELSA
 
[54]
2010 | Konferenz - Vortrag | ELSA-ID: 2892
B. Frahm, H. Brod, Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration, 2010.
ELSA
 
[53]
2010 | Konferenz - Vortrag | ELSA-ID: 2913
B. Dercks, B. Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, R. Zecirovic, Intensified absorption and distillation devices for modular chemical production processes, 2010.
ELSA
 
[52]
2009 | Patent | ELSA-ID: 2872
A. Braun, H. Brod, B. Frahm, M. Jenne, J. Kauling, S. Kirchner, Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen, (2009).
ELSA
 
[51]
2009 | Konferenz - Vortrag | ELSA-ID: 2912
B. Frahm, H. Brod, U. Langer, Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA), 2009.
ELSA
 
[50]
2009 | Konferenz - Poster | ELSA-ID: 2970
B. Frahm, H. Brod, U. Langer, Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA), 2009.
ELSA
 
[49]
2009 | Konferenz - Poster | ELSA-ID: 2971
W. Van Hecke, H. Van Langenhovve, B. Frahm, H. Brod, J. Dewulf, D. Haltrich, R. Ludwig, Upscaling the biocatalytic conversion of lactose to lactobionic acid with the dynamic membrane aeration reactor, 2009.
ELSA
 
[48]
2009 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2349 | OA
B. Frahm, H. Brod, U. Langer, Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration, Cytotechnology. 59 (2009) 17–30.
ELSA | DOI | Download (ext.)
 
[47]
2008 | Konferenz - Vortrag | ELSA-ID: 2911
H. Brod, J. Kauling, B. Frahm, M. Jenne, U. Langer, B. Bödeker, Pushing the Limits in High-Density Mammalian Cell Fermentation, 2008.
ELSA
 
[46]
2008 | Konferenz - Poster | ELSA-ID: 2968
B. Frahm, H. Brod, M. Burnett, U. Langer, B. Bödeker, High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA), 2008.
ELSA
 
[45]
2008 | Konferenz - Poster | ELSA-ID: 2969
B. Frahm, H. Brod, High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA), 2008.
ELSA
 
[44]
2007 | Konferenzband - Beitrag | ELSA-ID: 2814
R. Pörtner, B. Frahm, P. Lane, A. Munack, K. Kühn, V.C. Hass, Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller, Springer, Dordrecht, 2007.
ELSA | DOI
 
[43]
2007 | Patent | ELSA-ID: 2870 | OA
H. Brod, B. Frahm, J. Kauling, R. Rose, Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component, (2007).
ELSA | Download (ext.)
 
[42]
2007 | Patent | ELSA-ID: 2871
H. Brod, B. Frahm, J. Kauling, M. Poggel, R. Rose, S. Schmidt, Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen, (2007).
ELSA
 
[41]
2007 | Konferenz - Vortrag | ELSA-ID: 2909
H. Brod, B. Frahm, J. Kauling, Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen, 2007.
ELSA
 
[40]
2007 | Konferenz - Vortrag | ELSA-ID: 2910
H. Brod, B. Frahm, J. Kauling, Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen, 2007.
ELSA
 
[39]
2007 | Konferenz - Poster | ELSA-ID: 2967
B. Frahm, S. Kirchner, R. Rose, M. Jenne, J. Kauling, H. Brod, K. Jöris, M. Wischniewski, U. Langer, B. Bödeker, High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA), 2007.
ELSA
 
[38]
2007 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2348
B. Frahm, S. Kirchner, J. Kauling, H. Brod, U. Langer, B. Bödeker, Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien, Chemie Ingenieur Technik. 79 (2007) 1052–1058.
ELSA | DOI | Download (ext.)
 
[37]
2005 | Konferenzband - Beitrag | ELSA-ID: 2813
B. Frahm, R. Pörtner, Flexible Fed-Batch Process Control of Animal Cells, Springer, Dordrecht, 2005.
ELSA | DOI
 
[36]
2005 | Konferenz - Vortrag | ELSA-ID: 2907
R. Pörtner, B. Frahm, P. Lane, A. Munack, Optimisation of time-space-yield for hybridoma fed-batch cultures with an adaptive OLFO-controller, 2005.
ELSA
 
[35]
2005 | Konferenz - Vortrag | ELSA-ID: 2908
R. Pörtner, B. Frahm, V.C. Hass, P. Lane, A. Munack, Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode, 2005.
ELSA
 
[34]
2005 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2347 | OA
B. Frahm, P. Lane, A. Munack, R. Pörtner, Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode, Chemie Ingenieur Technik. 77 (2005) 429–435.
ELSA | DOI | Download (ext.)
 
[33]
2004 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2345 | OA
R. Pörtner, J.-O. Schwabe, B. Frahm, Evaluation of selected control strategies for fed-batch cultures of a hybridoma cell line, Biotechnology and Applied Biochemistry. 40 (2004).
ELSA | DOI | Download (ext.)
 
[32]
2003 | Konferenz - Vortrag | ELSA-ID: 7934
B. Frahm, R. Pörtner, Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies, 2003.
ELSA
 
[31]
2003 | Konferenzband - Beitrag | ELSA-ID: 2435
B. Frahm, B. Müller-Landré, G. Wiggers de Almeida, M. Singer, M. Rausch, P. Lane, A. Munack, V.C. Hass, R. Pörtner, Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control, Inst. für Bioprozess- und Analysenmesstechnik , Heiligenstadt, 2003.
ELSA
 
[30]
2003 | Konferenzband - Beitrag | ELSA-ID: 2436
K. Kühn, B. Frahm, R. Pörtner, P. Lane, A. Munack, V.C. Hass, Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells, ECCE4, Granada, 2003.
ELSA
 
[29]
2003 | Konferenz - Vortrag | ELSA-ID: 2902
B. Frahm, R. Pörtner, Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung, 2003.
ELSA
 
[28]
2003 | Konferenz - Vortrag | ELSA-ID: 2903
V.C. Hass, K. Kühn, B. Frahm, R. Pörtner, P. Lane, A. Munack, Ein strukturiertes Kompartiment-Modell zur Beschreibung der Kultivierung von Hybridomazellen als Teil einer adaptiven, modellgestützten Prozessführung, 2003.
ELSA
 
[27]
2003 | Konferenz - Vortrag | ELSA-ID: 2905
B. Frahm, P. Lane, A. Munack, V.C. Hass, R. Pörtner, Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies, 2003.
ELSA | Dateien verfügbar
 
[26]
2003 | Konferenz - Vortrag | ELSA-ID: 2906
R. Pörtner, B. Frahm, P. Lane, V.C. Hass, A. Munack, H. Märkl, Fed-Batch-Kultivierung tierischer Zellen – eine Herausforderung für eine adaptive, modellgestützte Steuerung, 2003.
ELSA
 
[25]
2003 | Konferenz - Poster | ELSA-ID: 2964
B. Frahm, R. Pörtner, CO2-off-gas measurement for animal cell culture processes, 2003.
ELSA
 
[24]
2003 | Konferenz - Poster | ELSA-ID: 2965
B. Frahm, R. Pörtner, Flexible fed-batch process control of animal cells, 2003.
ELSA
 
[23]
2003 | Konferenz - Poster | ELSA-ID: 2966
K. Kühn, B. Frahm, R. Pörtner, P. Lane, A. Munack, V.C. Hass, Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells, 2003.
ELSA
 
[22]
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2343 | OA
B. Frahm, V.C. Hass, P. Lane, A. Munack, H. Märkl, R. Pörtner, Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung, Chemie Ingenieur Technik. 75 (2003) 457–460.
ELSA | DOI | Download (ext.)
 
[21]
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2344 | OA
B. Frahm, P. Lane, H. Märkl, R. Pörtner, Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis, Bioprocess and Biosystems Engineering. 26 (2003) 1–10.
ELSA | DOI | Download (ext.)
 
[20]
2003 | Dissertation | ELSA-ID: 2393
B. Frahm, Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen, Books on Demand GmbH, Norderstedt, 2003.
ELSA
 
[19]
2002 | Konferenzband - Beitrag | ELSA-ID: 2431
B. Frahm, R. Pörtner, Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen, Kurt-Schwabe-Inst. , Meinsberg , 2002.
ELSA
 
[18]
2002 | Konferenz - Vortrag | ELSA-ID: 2897
B. Frahm, R. Pörtner, Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen, 2002.
ELSA
 
[17]
2002 | Konferenz - Vortrag | ELSA-ID: 2898
B. Frahm, R. Pörtner, Adaptive, model-based control by the OLFO-controller for the fed-batch cultivation of animal cells, 2002.
ELSA
 
[16]
2002 | Konferenz - Vortrag | ELSA-ID: 2899
B. Frahm, R. Pörtner, Adaptive, model-based control by the OLFO-controller for the fed-batch cultivation of animal cells, 2002.
ELSA
 
[15]
2002 | Konferenz - Vortrag | ELSA-ID: 2900
B. Frahm, B. Müller-Landré, G. Wiggers de Almeida, M. Singer, M. Rausch, P. Lane, A. Munack, V.C. Hass, R. Pörtner, Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control, 2002.
ELSA
 
[14]
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2340 | OA
B. Frahm, H.-C. Blank, P. Cornand, W. Oelßner, U. Guth, P. Lane, A. Munack, K. Johannsen, R. Pörtner, Determination of dissolved CO2 concentration and CO2 production rate of mammalian cell suspension culture based on off-gas measurement, Journal of Biotechnology. 99 (2002) 133–148.
ELSA | DOI | Download (ext.)
 
[13]
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2341 | OA
B. Frahm, P. Lane, H. Atzert, A. Munack, M. Hoffmann, V.C. Hass, R. Pörtner, Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Effective Fed-Batch Cultivation of Hybridoma Cells, Biotechnology Progress. 18 (2002) 1095–1103.
ELSA | DOI | Download (ext.)
 
[12]
2002 | Zeitschriftenaufsatz | ELSA-ID: 2342
B. Frahm, R. Pörtner, Reaktor-Abgasmessungen bei Zellkulturen, BIOforum. 4 (2002) 179–180.
ELSA
 
[11]
2001 | Konferenz - Vortrag | ELSA-ID: 7933
B. Frahm, R. Pörtner, Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen, 2001.
ELSA
 
[10]
2001 | Konferenzband - Beitrag | ELSA-ID: 2427
B. Frahm, H. Atzert, P. Lane, M. Hoffmann, V.C. Hass, A. Munack, R. Pörtner, Development of an Automated, Adaptive Model-Based Control for the Effective Cultivation of Hybridoma Cells, Springer, Dordrecht, 2001.
ELSA | DOI
 
[9]
2001 | Konferenz - Poster | ELSA-ID: 2429
V.C. Hass, P. Lane, M. Hoffmann, B. Frahm, J.-O. Schwabe, R. Pörtner, A. Munack, Model-Based Control of Hybridoma Cell Cultures, 2001.
ELSA
 
[8]
2001 | Konferenz - Vortrag | ELSA-ID: 2894
M. Hoffmann, V.C. Hass, B. Frahm, J.-O. Schwabe, R. Pörtner, P. Lane, A. Munack, Untersuchung verschiedener mathematischer Modelle in Hinblick auf ihre Eignung für die adaptive Prozessführung von Hybridoma Zellkulturen, 2001.
ELSA
 
[7]
2001 | Konferenz - Vortrag | ELSA-ID: 2895
B. Frahm, R. Pörtner, Arbeitsschwerpunkte TUHH, Bioprozess- und Bioverfahrenstechnik, Arbeitsgruppe Zellkulturtechnik, 2001.
ELSA
 
[6]
2001 | Konferenz - Poster | ELSA-ID: 2960
B. Frahm, H. Atzert, J.-O. Schwabe, P. Lane, A. Munack, M. Hoffmann, V.C. Hass, R. Pörtner, Adaptive modellgestützte Steuerung von Zellkulturprozessen, 2001.
ELSA
 
[5]
2001 | Konferenz - Poster | ELSA-ID: 2961
P. Lane, B. Frahm, H. Atzert, J.-O. Schwabe, M. Hoffmann, V.C. Hass, R. Pörtner, Design of Feeding Strategies for Fed-Batch Cultures of Animal Cells by the Method of Inequalities, 2001.
ELSA
 
[4]
2001 | Konferenz - Poster | ELSA-ID: 2962
B. Frahm, H. Atzert, P. Lane, M. Hoffmann, V.C. Hass, A. Munack, R. Pörtner, Development of an automated, model-based, adaptive control for the effective cultivation of hybridoma cells, 2001.
ELSA
 
[3]
2001 | Konferenzband - Beitrag | ELSA-ID: 2963 | OA
V.C. Hass, P. Lane, M. Hoffmann, B. Frahm, J.-O. Schwabe, R. Pörtner, A. Munack, Model-Based Control of Hybridoma Cell Cultures, ScienceDirect, Oxford, 2001.
ELSA | DOI | Download (ext.)
 
[2]
2000 | Konferenz - Vortrag | ELSA-ID: 2893
T. Anderelei, B. Frahm, J. Büchs, Online-Bestimmung der Sauerstofftransferrate (OTR) und der Kohlendioxidtransferrate (CTR) in geschüttelten Bioreaktoren, 2000.
ELSA
 
[1]
2000 | Konferenz - Poster | ELSA-ID: 2959
M. Hoffmann, B. Frahm, J.-O. Schwabe, P. Lane, R. Pörtner, V.C. Hass, A. Munack, Modellgestützte Prozessführung für Hybridoma-Kulturen mit Hilfe des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus, 2000.
ELSA
 
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[168]
2024 | Konferenz - Vortrag | ELSA-ID: 12021
J. Segermann, M. Luttmann, A. Blome, S. Feldt, S. Sivanesan, C.-A. Holst, V. Lohweg, B. Frahm, U. Müller, Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie, 2024.
ELSA
 
[167]
2024 | Konferenz - Vortrag | ELSA-ID: 12022
M. Luttmann, A. Blome, J. Segermann, M. Jekle, B. Frahm, U. Müller, Erkenntnisse zur Nutzung von Photogrammmetrie für die Untersuchung des Bräunungsverhaltens von Weizenbrötchen, 2024.
ELSA
 
[166]
2024 | Konferenz - Poster | ELSA-ID: 12395
C. Müller, J. Alarinta, B. Frahm, G. Wirtanen, Investigation of microbial spoilage in vegan foods, 2024.
ELSA
 
[165]
2024 | Konferenz - Poster | ELSA-ID: 12396
V. Gassenmeier, G. Campolongo, B. Frahm, Dissolved Carbon Dioxide in Addition to Dissolved Oxygen for In-situ Monitoring of Hybridoma Cell Culture, 2024.
ELSA
 
[164]
2024 | Konferenz - Poster | ELSA-ID: 12397
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Process optimization in baked goods production using inline sensors and objective product evaluation, 2024.
ELSA
 
[163]
2024 | Preprint | ELSA-ID: 12400 | OA
S. Ramm, U. Odefey, B. Frahm, M. Pein-Hackelbusch, Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters, (2024).
ELSA | DOI | Download (ext.)
 
[162]
2024 | Konferenz - Poster | ELSA-ID: 10957
L. Reinhardt, V. Gassenmeier, S. Feldt, S. Plate, M. Tremmel, B. Frahm, M. Stosch, Mycelium-based materials from residues of the regional wood industry, n.d.
ELSA
 
[161]
2024 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 12402
P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator, Chemie Ingenieur Technik. 96 (2024) 528–534.
ELSA | DOI | WoS
 
[160]
2023 | Konferenz - Poster | ELSA-ID: 11378
V. Gassenmeier, G. Campolongo, B. Frahm, Real-time Monitoring of DCO2 in addition to DO, n.d.
ELSA
 
[159]
2023 | Konferenz - Poster | ELSA-ID: 11381
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development, DECHEMA e.V., n.d.
ELSA
 
[158]
2023 | Konferenz - Poster | ELSA-ID: 11382 | OA
V. Gassenmeier, F. Kuhfuß, S. Deppe, G. Ifrim, T. Hernández Rodriguez, B. Frahm, View on a mechanistic model of Chlorella vulgaris in shake flasks, n.d.
ELSA | Download (ext.)
 
[157]
2023 | Konferenz - Vortrag | ELSA-ID: 11383
T. Hernández Rodriguez, C. Posch, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture, DECHEMA e.V., 2023.
ELSA
 
[156]
2023 | Konferenzband - Beitrag | ELSA-ID: 11384 | OA
C. Müller, J. Alarinta, B. Frahm, G. Wirtanen, Microbial spoilage in vegan foods, Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draženka Komes, Sanja Vidaček Filipec and Bojana Voučko, 2023.
ELSA | Download (ext.)
 
[155]
2023 | Konferenz - Poster | ELSA-ID: 11487 | OA
S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression , DECHEMA e.V., n.d.
ELSA | Download (ext.)
 
[154]
2023 | Konferenz - Poster | ELSA-ID: 10201 | OA
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development, 2023.
ELSA | Download (ext.)
 
[153]
2023 | Konferenz - Vortrag | ELSA-ID: 11109
A. Blome, M. Luttmann, M. Jekle, B. Frahm, U. Müller, Untersuchung der räumlichen Verteilung von viskoelastischen Kenngrößen während der Weizenteigbereitung, 2023.
ELSA
 
[152]
2023 | Konferenz - Poster | ELSA-ID: 11110
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung, 2023.
ELSA
 
[151]
2023 | Konferenz - Poster | ELSA-ID: 12483
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung, 2023.
ELSA
 
[150]
2023 | Konferenz - Poster | ELSA-ID: 12485
M. Luttmann, A. Blome, M. Jekle, B. Frahm, U. Müller, Teig 4.0 - Promotionsthemen, 2023.
ELSA
 
[149]
2023 | Konferenzband - Beitrag | ELSA-ID: 10788 | OA
S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, IEEE, [Piscataway, NJ], 2023.
ELSA | DOI | Download (ext.)
 
[148]
2023 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11385
P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations, Chemie Ingenieur Technik. 95 (2023) 1960–1969.
ELSA | DOI | WoS
 
[147]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11377
T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design, Processes. 10 (2022).
ELSA | DOI
 
[146]
2022 | Konferenz - Poster | ELSA-ID: 7932
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development, n.d.
ELSA
 
[145]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7976
V. Gassenmeier, S. Deppe, T. Hernández Rodriguez, F. Kuhfuß, A. Moser, V.C. Hass, K.B. Kuchemüller, R. Pörtner, J. Möller, G.A. Ifrim, B. Frahm, Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology, Current Research in Biotechnology. 4 (2022) 102–119.
ELSA | DOI
 
[144]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7977
F. Kuhfuß, V. Gassenmeier, S. Deppe, G.A. Ifrim, T. Hernández Rodriguez, B. Frahm, View on a mechanistic model of Chlorella vulgaris in incubated shake flasks, Bioprocess and Biosystems Engineering. 45 (2022) 15–30.
ELSA | DOI
 
[143]
2022 | Datenpublikation | ELSA-ID: 10190
V. Gassenmeier, B. Frahm, Real-time Monitoring of DCO2 in addition to DO, assets-labs, 2022.
ELSA | Dateien verfügbar
 
[142]
2022 | Sammelwerk - Beitrag | ELSA-ID: 10193
T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design, in: R. Pörtner, J. Möller (Eds.), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2022: pp. 21–48.
ELSA | DOI
 
[141]
2022 | Konferenzband - Beitrag | ELSA-ID: 10195
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Process optimisation in the field of wheat dough processing using real-time recording of quality-relevant characteristics in raw materials, intermediates and final products, Versuchsanstalt der Hefeindustrie e.V., 2022.
ELSA
 
[140]
2022 | Konferenz - Vortrag | ELSA-ID: 10196
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Process optimisation in the field of wheat dough processing using real-time recording of quality-relevant characteristics in raw materials, intermediates and final products, 2022.
ELSA
 
[139]
2022 | Konferenz - Vortrag | ELSA-ID: 10197
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture, 2022.
ELSA
 
[138]
2022 | Konferenz - Poster | ELSA-ID: 10198
T. Hernández Rodriguez, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion, n.d.
ELSA
 
[137]
2022 | Konferenz - Poster | ELSA-ID: 10199 | OA
C. Müller, J. Alarinta, B. Frahm, G. Wirtanen, Microbial spoilage in vegan foods, 2022.
ELSA | Download (ext.)
 
[136]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11376
T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study, Processes. 9 (2021).
ELSA | DOI
 
[135]
2021 | Konferenz - Vortrag | ELSA-ID: 7927
T. Hernández Rodriguez, B. Frahm, Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction, 2021.
ELSA
 
[134]
2021 | Konferenz - Poster | ELSA-ID: 7931
A. Moser, J. Möller, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, B. Frahm, R. Pörtner, V.C. Hass, Model-assisted Design of Experiments - Concept, Software and Applications, 2021.
ELSA
 
[133]
2021 | Lexikoneintrag | ELSA-ID: 7939
G. Wirtanen, J. Alarinta, B. Frahm, S. Fasse, Bovine Colostrum for Human Consumption, in: MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science, 2021.
ELSA
 
[132]
2021 | Sammelwerk - Beitrag | ELSA-ID: 7983
T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study, in: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2021: pp. 49–74.
ELSA | DOI
 
[131]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train, Bioprocess and Biosystems Engineering. 44 (2021) 793–808.
ELSA | DOI
 
[130]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7986
A. Moser, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, B. Frahm, R. Pörtner, V.C. Hass, J. Möller, Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses, Bioprocess and Biosystems Engineering. 44 (2021) 683–700.
ELSA | DOI
 
[129]
2021 | Konferenz - Vortrag | ELSA-ID: 8078
A. Blome, M. Luttmann, B. Frahm, U. Müller, Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung, 2021.
ELSA
 
[128]
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
T. Hernández Rodriguez, B. Frahm, Digital Seed Train Twins and Statistical Methods, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digital Twins Tools and Concepts for Smart Biomanufacturing, Springer, Berlin, Heidelberg, 2021: pp. 97–131.
ELSA | DOI
 
[127]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7981
S. Fasse, J. Alarinta, B. Frahm, G. Wirtanen, Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing, Dairy. 2 (2021) 556–575.
ELSA | DOI | WoS
 
[126]
2020 | Konferenz - Poster | ELSA-ID: 7929
T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration, 2020.
ELSA
 
[125]
2020 | Konferenz - Poster | ELSA-ID: 7930
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes, 2020.
ELSA
 
[124]
2020 | Konferenz - Vortrag | ELSA-ID: 7936
T. Hernández Rodriguez, B. Frahm, C. Posch, Integration of prior knowledge and digital tools for uncertainty-based decision support, 2020.
ELSA
 
[123]
2020 | Konferenzband - Beitrag | ELSA-ID: 7937
T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration, Wiley, 2020.
ELSA | DOI
 
[122]
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes, Wiley, 2020.
ELSA | DOI
 
[121]
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, Claus Weihs, R. Pörtner, B. Frahm, Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach, BioMed Central, 2020.
ELSA | Dateien verfügbar | DOI
 
[120]
2020 | Konferenz - Poster | ELSA-ID: 3007
F. Kuhfuß, M. Tölle, T. Hernández Rodriguez, V. Gassenmeier, S. Deppe, G.A. Ifrim, B. Frahm, Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration, 2020.
ELSA
 
[119]
2020 | Konferenz - Poster | ELSA-ID: 3008
S. Deppe, F. Kuhfuß, M. Tölle, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, J. Möller, R. Pörtner, A. Moser, V.C. Hass, B. Frahm, Model-assisted Design of Experiments for algae cultivation, 2020.
ELSA
 
[118]
2020 | Konferenz - Poster | ELSA-ID: 3009
G.A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, B. Frahm, Modeling of microalgae in an air-lift photobioreactor for biomass production, 2020.
ELSA
 
[117]
2020 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2392
J. Möller, T. Hernández Rodríguez, J. Müller, L. Arndt, K.B. Kuchemüller, B. Frahm, R. Eibl, D. Eibl, R. Pörtner, Model uncertainty-based evaluation of process strategies during scale-up of biopharmaceutical processes, Computers & Chemical Engineering. 134 (2020) 1–13.
ELSA | DOI
 
[116]
2020 | Sammelwerk - Beitrag | ELSA-ID: 2397
T. Hernández Rodríguez, B. Frahm, Design, Optimization and Adaptive Control of Cell Culture Seed Trains, in: R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols, Springer, Berlin, Heidelberg, New York, 2020: pp. 251–267.
ELSA | DOI
 
[115]
2020 | Sammelwerk - Beitrag | ELSA-ID: 2399
S. Deppe, B. Frahm, V.C. Hass, T. Hernández Rodríguez, K.B. Kuchemüller, J. Möller, R. Pörtner, Estimation of Process Model Parameters, in: R. Pörtner (Ed.), Animal Cell Biotechnology: Methods and Protocols, Springer, Berlin ; Heidelberg ; New York, 2020: pp. 213–234.
ELSA | DOI
 
[114]
2019 | Konferenz - Vortrag | ELSA-ID: 7928
B. Frahm, Scale-up of stirred vessels, 2019.
ELSA
 
[113]
2019 | Konferenz - Vortrag | ELSA-ID: 2956
J. Möller, J. Müller, T. Hernández Rodriguez, K.B. Kuchemüller, L. Arndt, B. Frahm, R. Eibl, D. Eibl, R. Pörtner, Workflow for model-assisted design and scale-up of biopharmaceutical production processes, 2019.
ELSA
 
[112]
2019 | Konferenz - Vortrag | ELSA-ID: 2957
J. Möller, K.B. Kuchemüller, A. Moser, V.C. Hass, T. Hernández Rodriguez, S. Deppe, B. Frahm, R. Pörtner, Model-Assisted Design of Experiments, 2019.
ELSA
 
[111]
2019 | Konferenz - Vortrag | ELSA-ID: 2958
G.A. Ifrim, M. Titica, S. Deppe, B. Frahm, M. Barbu, S. Caraman, Novel control strategy for microalgae in photobioreactor, 2019.
ELSA
 
[110]
2019 | Konferenz - Poster | ELSA-ID: 3000
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019.
ELSA
 
[109]
2019 | Konferenz - Poster | ELSA-ID: 3001
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019.
ELSA
 
[108]
2019 | Konferenz - Poster | ELSA-ID: 3002
J. Möller, K.B. Kuchemüller, T. Hernández Rodriguez, S. Deppe, G.A. Ifrim, A. Moser, V.C. Hass, B. Frahm, R. Pörtner, Model-Assisted Design of Experiments – Software Toolbox, 2019.
ELSA
 
[107]
2019 | Konferenz - Poster | ELSA-ID: 3003
S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, M. Tölle, F. Kuhfuß, J. Möller, K.B. Kuchemüller, R. Pörtner, A. Moser, V.C. Hass, G.A. Ifrim, B. Frahm, Model-assisted Design of Experiments for algae cultivation, 2019.
ELSA
 
[106]
2019 | Konferenz - Poster | ELSA-ID: 3004
G.A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, B. Frahm, Modeling of microalgae in an air-lift photobioreactor for biomass production, 2019.
ELSA
 
[105]
2019 | Konferenz - Poster | ELSA-ID: 3005
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019.
ELSA
 
[104]
2019 | Konferenz - Poster | ELSA-ID: 3006
G.A. Ifrim, M. Titica, S. Deppe, B. Frahm, M. Barbu, S. Caraman, Multivariable control strategy for the photosynthetic cultures of microalgae, 2019.
ELSA
 
[103]
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 | OA
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, C. Weihs, R. Pörtner, B. Frahm, Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method, Biotechnology and Bioengineering. 116 (2019) 2944–2959.
ELSA | DOI | Download (ext.)
 
[102]
2019 | Konferenzband - Beitrag | ELSA-ID: 2400
G.A. Ifrim, M. Titica, S. Deppe, B. Frahm, M. Barbu, S. Caraman, Multivariable control strategy for the photosynthetic cultures of microalgae, IEEE, 2019.
ELSA | DOI
 
[101]
2018 | Konferenz - Vortrag | ELSA-ID: 7935
T. Hernández Rodriguez, B. Frahm, C. Posch, J. Schmutzhard, J. Stettner, A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization, 2018.
ELSA
 
[100]
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
T. Hernández Rodriguez, S. Krull, V.C. Hass, J. Möller, R. Pörtner, B. Frahm, Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization, BioMed Central, 2018.
ELSA | Dateien verfügbar | DOI
 
[99]
2018 | Konferenz - Vortrag | ELSA-ID: 2955
R. Pörtner, J. Möller, B. Frahm, V.C. Hass, Model-Assisted Design of Process Strategies for Cell Culture Processes, 2018.
ELSA
 
[98]
2018 | Konferenz - Poster | ELSA-ID: 2997
J. Möller, K.B. Kuchemüller, F. Freiberger, P. Levermann, T. Hernández Rodriguez, B. Frahm, V.C. Hass, R. Pörtner, Model-Assisted Design and Optimization of Process Strategies, 2018.
ELSA
 
[97]
2018 | Konferenz - Poster | ELSA-ID: 2999
T. Hernández Rodriguez, J. Möller, K.B. Kuchemüller, F. Freiberger, P. Levermann, V.C. Hass, B. Frahm, R. Pörtner, Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses, 2018.
ELSA
 
[96]
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 | OA
J. Möller, K.B. Kuchemüller, T. Hernández Rodriguez, B. Frahm, V.C. Hass, R. Pörtner, Model-Assisted Design of Process Strategies for Cell Culture Processes, American Pharmaceutical Review. 3 (2018) 39–41.
ELSA | Download (ext.)
 
[95]
2017 | Konferenz - Vortrag | ELSA-ID: 2920
T. Hernández Rodriguez, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017.
ELSA
 
[94]
2017 | Konferenz - Vortrag | ELSA-ID: 2921
R. Pörtner, J. Möller, T. Hernández Rodriguez, B. Frahm, V.C. Hass, Model-assisted design and optimization of biotechnological processes, 2017.
ELSA
 
[93]
2017 | Konferenz - Vortrag | ELSA-ID: 2950
T. Hernández Rodriguez, K.S. Koopmann, J. Klaes, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017.
ELSA
 
[92]
2017 | Konferenz - Poster | ELSA-ID: 2994
T. Hernández Rodriguez, K.S. Koopmann, R. Pörtner, B. Frahm, Influence of parameter accuracies in cell culture seed train simulations, 2017.
ELSA
 
[91]
2017 | Konferenz - Poster | ELSA-ID: 2995
T. Hernández Rodriguez, S. Krull, V.C. Hass, J. Möller, R. Pörtner, B. Frahm, Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization, 2017.
ELSA
 
[90]
2017 | Konferenz - Poster | ELSA-ID: 2996
T. Hernández Rodriguez, S. Krull, V.C. Hass, R. Pörtner, B. Frahm, Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization, 2017.
ELSA
 
[89]
2016 | Konferenz - Poster | ELSA-ID: 2991
U. Beshay, S. Feldt, B. Schwarze, P. Wefing, T. Hahne, J. Moschinski, C. Müller, R. Büker, M. Kramer, H. Brod, B. Frahm, DMA Photobioreactor System – Cultivation at low shear stress and optional membrane aeration, 2016.
ELSA
 
[88]
2016 | Konferenz - Poster | ELSA-ID: 2992
T. Hernández Rodriguez, S. Vörtler, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, A software tool for biopharmaceutical seed train design and optimization, 2016.
ELSA
 
[87]
2016 | Konferenz - Poster | ELSA-ID: 2993
K.S. Koopmann, T. Hernández Rodriguez, S. Vörtler, U. Beshay, J. Möller, R. Pörtner, B. Frahm, Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies, 2016.
ELSA
 
[86]
2016 | Sammelwerk - Beitrag | ELSA-ID: 2395
R. Pörtner, O. Platas Barradas, B. Frahm, V.C. Hass, Advanced Process and Control Strategies for Bioreactors, in: Current Developments in Biotechnology and Bioengineering: Bioprocesses, Bioreactors and Controls, Elsevier, Amsterdam, 2016: pp. 463–493.
ELSA | DOI
 
[85]
2015 | Konferenzband - Beitrag | ELSA-ID: 2819 | OA
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for cell passaging in cell culture seed trains, BioMed Central, 2015.
ELSA | DOI | Download (ext.)
 
[84]
2015 | Konferenzband - Beitrag | ELSA-ID: 2820 | OA
S. Kern, O. Platas Barradas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-based strategy for cell culture seed train layout verified at lab scale, BioMed Central, 2015.
ELSA | DOI | Download (ext.)
 
[83]
2015 | Konferenz - Vortrag | ELSA-ID: 2917
B. Frahm, R. Pörtner, S. Kern, T. Hernández Rodriguez, Seed train design and optimization for animal cell suspension culture, 2015.
ELSA | Dateien verfügbar
 
[82]
2015 | Konferenz - Vortrag | ELSA-ID: 2919
B. Frahm, T. Hernández Rodriguez, S. Kern, K.S. Koopmann, U. Beshay, O. Platas-Barradas, R. Pörtner, Seed train design and optimization for animal cell suspension culture, 2015.
ELSA
 
[81]
2015 | Konferenz - Poster | ELSA-ID: 2985
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for cell passaging in cell culture seed trains, 2015.
ELSA
 
[80]
2015 | Konferenz - Poster | ELSA-ID: 2986
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-based strategy for cell culture seed train layout verified at lab scale, 2015.
ELSA
 
[79]
2015 | Konferenz - Poster | ELSA-ID: 2987
T. Hernández Rodriguez, R. Pörtner, B. Frahm, A software tool for biopharmaceutical seed train design and optimization, 2015.
ELSA
 
[78]
2015 | Konferenz - Poster | ELSA-ID: 2988
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for cell passaging in cell culture seed trains, 2015.
ELSA
 
[77]
2015 | Konferenz - Poster | ELSA-ID: 2990
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-based strategy for cell culture seed train layout verified at lab scale, 2015.
ELSA
 
[76]
2015 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2389
S. Kern, O. Platas-Barradas, R. Pörtner, B. Frahm, Model-based strategy for cell culture seed train layout verified at lab scale, Cytotechnology. 68 (2015) 1019–1032.
ELSA | DOI | Download (ext.)
 
[75]
2014 | Patent | ELSA-ID: 2878
B. Frahm, U. Meier, Beleuchtung von disposable Bioreaktoren, (2014).
ELSA
 
[74]
2014 | Konferenz - Poster | ELSA-ID: 2984
F. Drews, G. Drews, C. Folz, G. Platz, T. Gassenmeier, M. Kramer, C. Hundeiker, B. Schwarze, B. Frahm, Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche, 2014.
ELSA
 
[73]
2014 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2388
T. Hahne, B. Schwarze, M. Kramer, B. Frahm, Disposable algae cultivation for high-value products using all around LED-illumination directly on the bags, Journal of Algal Biomass Utilization. 5 (2014) 66–73.
ELSA
 
[72]
2013 | Konferenzband - Beitrag | ELSA-ID: 2817 | OA
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed train optimization for suspension cell culture, BioMed Central , 2013.
ELSA | DOI | Download (ext.)
 
[71]
2013 | Konferenzband - Beitrag | ELSA-ID: 2818 | OA
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-based design of the first steps of a seed train for cell culture processes, BioMed Central, 2013.
ELSA | DOI | Download (ext.)
 
[70]
2013 | Konferenz - Poster | ELSA-ID: 2980
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Modellgestützte Auslegung der ersten Schritte eines Seed-Trains für Zellkulturprozesse, 2013.
ELSA
 
[69]
2013 | Konferenz - Poster | ELSA-ID: 2981
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-based design of the first steps of a seed train for cell culture processes, 2013.
ELSA
 
[68]
2013 | Konferenz - Poster | ELSA-ID: 2982
T. Hahne, B. Schwarze, J. Moschinski, A. Kuttig, M. Kramer, B. Frahm, Disposable Algenkultivierung für hochpreisige Produkte mittels LED-Rundumbeleuchtung direkt auf den Bags, 2013.
ELSA
 
[67]
2013 | Konferenz - Poster | ELSA-ID: 2983
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed train optimization for suspension cell culture, 2013.
ELSA
 
[66]
2013 | Sammelwerk - Beitrag | ELSA-ID: 10214
B. Frahm, Seed Train Optimization for Cell Culture, in: R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols, 3rd ed., Humana Press, Totowa, NJ, 2013: pp. 355–367.
ELSA | DOI
 
[65]
2012 | Konferenzband - Beitrag | ELSA-ID: 2816 | OA
B. Frahm, H. Brod, Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA), Springer, Dordrecht, 2012.
ELSA | DOI | Download (ext.)
 
[64]
2012 | Patent | ELSA-ID: 2877
H. Brod, B. Frahm, Photobioreaktor mit rotatorisch oszillierenden Lichtquellen, (2012).
ELSA
 
[63]
2012 | Konferenz - Vortrag | ELSA-ID: 2918
W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, R. Ludwig, Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor, Vogel Business Media, 2012.
ELSA
 
[62]
2012 | Konferenz - Poster | ELSA-ID: 2973
R. Marzougui, R. Pörtner, B. Frahm, Optimierung des Seed trains von Suspensions-Zellkulturen, 2012.
ELSA
 
[61]
2011 | Patent | ELSA-ID: 2876
H. Brod, B. Frahm, M. Jenne, J. Kauling, F. Schmitt, J. Seletzky, Flüssigkeitsbegaser, (2011).
ELSA
 
[60]
2011 | Konferenz - Poster | ELSA-ID: 2972
W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, R. Ludwig, Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor, 2011.
ELSA
 
[59]
2011 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2350
W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, J. Dewulf, H. Van Langenhove, R. Ludwig, A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor, Journal of Molecular Catalysis B: Enzymatic. 68 (2011) 154–161.
ELSA | DOI | Download (ext.)
 
[58]
2010 | Konferenzband - Beitrag | ELSA-ID: 2815
B. Dercks, B. Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, R. Zecirovic, Intensified absorption and distillation devices for modular chemical production processes, Czech Society of Chemical Engineering, 2010.
ELSA
 
[57]
2010 | Patent | ELSA-ID: 2873
H. Brod, B. Frahm, J. Kauling, Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen, (2010).
ELSA
 
[56]
2010 | Patent | ELSA-ID: 2874
H. Brod, B. Frahm, M. Jenne, J. Kauling, Bioreaktor, (2010).
ELSA
 
[55]
2010 | Patent | ELSA-ID: 2875
B. Frahm, J. Kauling, A. Pütz, M. Schindler, Begasungssystem, (2010).
ELSA
 
[54]
2010 | Konferenz - Vortrag | ELSA-ID: 2892
B. Frahm, H. Brod, Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration, 2010.
ELSA
 
[53]
2010 | Konferenz - Vortrag | ELSA-ID: 2913
B. Dercks, B. Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, R. Zecirovic, Intensified absorption and distillation devices for modular chemical production processes, 2010.
ELSA
 
[52]
2009 | Patent | ELSA-ID: 2872
A. Braun, H. Brod, B. Frahm, M. Jenne, J. Kauling, S. Kirchner, Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen, (2009).
ELSA
 
[51]
2009 | Konferenz - Vortrag | ELSA-ID: 2912
B. Frahm, H. Brod, U. Langer, Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA), 2009.
ELSA
 
[50]
2009 | Konferenz - Poster | ELSA-ID: 2970
B. Frahm, H. Brod, U. Langer, Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA), 2009.
ELSA
 
[49]
2009 | Konferenz - Poster | ELSA-ID: 2971
W. Van Hecke, H. Van Langenhovve, B. Frahm, H. Brod, J. Dewulf, D. Haltrich, R. Ludwig, Upscaling the biocatalytic conversion of lactose to lactobionic acid with the dynamic membrane aeration reactor, 2009.
ELSA
 
[48]
2009 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2349 | OA
B. Frahm, H. Brod, U. Langer, Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration, Cytotechnology. 59 (2009) 17–30.
ELSA | DOI | Download (ext.)
 
[47]
2008 | Konferenz - Vortrag | ELSA-ID: 2911
H. Brod, J. Kauling, B. Frahm, M. Jenne, U. Langer, B. Bödeker, Pushing the Limits in High-Density Mammalian Cell Fermentation, 2008.
ELSA
 
[46]
2008 | Konferenz - Poster | ELSA-ID: 2968
B. Frahm, H. Brod, M. Burnett, U. Langer, B. Bödeker, High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA), 2008.
ELSA
 
[45]
2008 | Konferenz - Poster | ELSA-ID: 2969
B. Frahm, H. Brod, High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA), 2008.
ELSA
 
[44]
2007 | Konferenzband - Beitrag | ELSA-ID: 2814
R. Pörtner, B. Frahm, P. Lane, A. Munack, K. Kühn, V.C. Hass, Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller, Springer, Dordrecht, 2007.
ELSA | DOI
 
[43]
2007 | Patent | ELSA-ID: 2870 | OA
H. Brod, B. Frahm, J. Kauling, R. Rose, Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component, (2007).
ELSA | Download (ext.)
 
[42]
2007 | Patent | ELSA-ID: 2871
H. Brod, B. Frahm, J. Kauling, M. Poggel, R. Rose, S. Schmidt, Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen, (2007).
ELSA
 
[41]
2007 | Konferenz - Vortrag | ELSA-ID: 2909
H. Brod, B. Frahm, J. Kauling, Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen, 2007.
ELSA
 
[40]
2007 | Konferenz - Vortrag | ELSA-ID: 2910
H. Brod, B. Frahm, J. Kauling, Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen, 2007.
ELSA
 
[39]
2007 | Konferenz - Poster | ELSA-ID: 2967
B. Frahm, S. Kirchner, R. Rose, M. Jenne, J. Kauling, H. Brod, K. Jöris, M. Wischniewski, U. Langer, B. Bödeker, High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA), 2007.
ELSA
 
[38]
2007 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2348
B. Frahm, S. Kirchner, J. Kauling, H. Brod, U. Langer, B. Bödeker, Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien, Chemie Ingenieur Technik. 79 (2007) 1052–1058.
ELSA | DOI | Download (ext.)
 
[37]
2005 | Konferenzband - Beitrag | ELSA-ID: 2813
B. Frahm, R. Pörtner, Flexible Fed-Batch Process Control of Animal Cells, Springer, Dordrecht, 2005.
ELSA | DOI
 
[36]
2005 | Konferenz - Vortrag | ELSA-ID: 2907
R. Pörtner, B. Frahm, P. Lane, A. Munack, Optimisation of time-space-yield for hybridoma fed-batch cultures with an adaptive OLFO-controller, 2005.
ELSA
 
[35]
2005 | Konferenz - Vortrag | ELSA-ID: 2908
R. Pörtner, B. Frahm, V.C. Hass, P. Lane, A. Munack, Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode, 2005.
ELSA
 
[34]
2005 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2347 | OA
B. Frahm, P. Lane, A. Munack, R. Pörtner, Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode, Chemie Ingenieur Technik. 77 (2005) 429–435.
ELSA | DOI | Download (ext.)
 
[33]
2004 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2345 | OA
R. Pörtner, J.-O. Schwabe, B. Frahm, Evaluation of selected control strategies for fed-batch cultures of a hybridoma cell line, Biotechnology and Applied Biochemistry. 40 (2004).
ELSA | DOI | Download (ext.)
 
[32]
2003 | Konferenz - Vortrag | ELSA-ID: 7934
B. Frahm, R. Pörtner, Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies, 2003.
ELSA
 
[31]
2003 | Konferenzband - Beitrag | ELSA-ID: 2435
B. Frahm, B. Müller-Landré, G. Wiggers de Almeida, M. Singer, M. Rausch, P. Lane, A. Munack, V.C. Hass, R. Pörtner, Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control, Inst. für Bioprozess- und Analysenmesstechnik , Heiligenstadt, 2003.
ELSA
 
[30]
2003 | Konferenzband - Beitrag | ELSA-ID: 2436
K. Kühn, B. Frahm, R. Pörtner, P. Lane, A. Munack, V.C. Hass, Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells, ECCE4, Granada, 2003.
ELSA
 
[29]
2003 | Konferenz - Vortrag | ELSA-ID: 2902
B. Frahm, R. Pörtner, Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung, 2003.
ELSA
 
[28]
2003 | Konferenz - Vortrag | ELSA-ID: 2903
V.C. Hass, K. Kühn, B. Frahm, R. Pörtner, P. Lane, A. Munack, Ein strukturiertes Kompartiment-Modell zur Beschreibung der Kultivierung von Hybridomazellen als Teil einer adaptiven, modellgestützten Prozessführung, 2003.
ELSA
 
[27]
2003 | Konferenz - Vortrag | ELSA-ID: 2905
B. Frahm, P. Lane, A. Munack, V.C. Hass, R. Pörtner, Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies, 2003.
ELSA | Dateien verfügbar
 
[26]
2003 | Konferenz - Vortrag | ELSA-ID: 2906
R. Pörtner, B. Frahm, P. Lane, V.C. Hass, A. Munack, H. Märkl, Fed-Batch-Kultivierung tierischer Zellen – eine Herausforderung für eine adaptive, modellgestützte Steuerung, 2003.
ELSA
 
[25]
2003 | Konferenz - Poster | ELSA-ID: 2964
B. Frahm, R. Pörtner, CO2-off-gas measurement for animal cell culture processes, 2003.
ELSA
 
[24]
2003 | Konferenz - Poster | ELSA-ID: 2965
B. Frahm, R. Pörtner, Flexible fed-batch process control of animal cells, 2003.
ELSA
 
[23]
2003 | Konferenz - Poster | ELSA-ID: 2966
K. Kühn, B. Frahm, R. Pörtner, P. Lane, A. Munack, V.C. Hass, Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells, 2003.
ELSA
 
[22]
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2343 | OA
B. Frahm, V.C. Hass, P. Lane, A. Munack, H. Märkl, R. Pörtner, Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung, Chemie Ingenieur Technik. 75 (2003) 457–460.
ELSA | DOI | Download (ext.)
 
[21]
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2344 | OA
B. Frahm, P. Lane, H. Märkl, R. Pörtner, Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis, Bioprocess and Biosystems Engineering. 26 (2003) 1–10.
ELSA | DOI | Download (ext.)
 
[20]
2003 | Dissertation | ELSA-ID: 2393
B. Frahm, Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen, Books on Demand GmbH, Norderstedt, 2003.
ELSA
 
[19]
2002 | Konferenzband - Beitrag | ELSA-ID: 2431
B. Frahm, R. Pörtner, Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen, Kurt-Schwabe-Inst. , Meinsberg , 2002.
ELSA
 
[18]
2002 | Konferenz - Vortrag | ELSA-ID: 2897
B. Frahm, R. Pörtner, Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen, 2002.
ELSA
 
[17]
2002 | Konferenz - Vortrag | ELSA-ID: 2898
B. Frahm, R. Pörtner, Adaptive, model-based control by the OLFO-controller for the fed-batch cultivation of animal cells, 2002.
ELSA
 
[16]
2002 | Konferenz - Vortrag | ELSA-ID: 2899
B. Frahm, R. Pörtner, Adaptive, model-based control by the OLFO-controller for the fed-batch cultivation of animal cells, 2002.
ELSA
 
[15]
2002 | Konferenz - Vortrag | ELSA-ID: 2900
B. Frahm, B. Müller-Landré, G. Wiggers de Almeida, M. Singer, M. Rausch, P. Lane, A. Munack, V.C. Hass, R. Pörtner, Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control, 2002.
ELSA
 
[14]
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2340 | OA
B. Frahm, H.-C. Blank, P. Cornand, W. Oelßner, U. Guth, P. Lane, A. Munack, K. Johannsen, R. Pörtner, Determination of dissolved CO2 concentration and CO2 production rate of mammalian cell suspension culture based on off-gas measurement, Journal of Biotechnology. 99 (2002) 133–148.
ELSA | DOI | Download (ext.)
 
[13]
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2341 | OA
B. Frahm, P. Lane, H. Atzert, A. Munack, M. Hoffmann, V.C. Hass, R. Pörtner, Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Effective Fed-Batch Cultivation of Hybridoma Cells, Biotechnology Progress. 18 (2002) 1095–1103.
ELSA | DOI | Download (ext.)
 
[12]
2002 | Zeitschriftenaufsatz | ELSA-ID: 2342
B. Frahm, R. Pörtner, Reaktor-Abgasmessungen bei Zellkulturen, BIOforum. 4 (2002) 179–180.
ELSA
 
[11]
2001 | Konferenz - Vortrag | ELSA-ID: 7933
B. Frahm, R. Pörtner, Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen, 2001.
ELSA
 
[10]
2001 | Konferenzband - Beitrag | ELSA-ID: 2427
B. Frahm, H. Atzert, P. Lane, M. Hoffmann, V.C. Hass, A. Munack, R. Pörtner, Development of an Automated, Adaptive Model-Based Control for the Effective Cultivation of Hybridoma Cells, Springer, Dordrecht, 2001.
ELSA | DOI
 
[9]
2001 | Konferenz - Poster | ELSA-ID: 2429
V.C. Hass, P. Lane, M. Hoffmann, B. Frahm, J.-O. Schwabe, R. Pörtner, A. Munack, Model-Based Control of Hybridoma Cell Cultures, 2001.
ELSA
 
[8]
2001 | Konferenz - Vortrag | ELSA-ID: 2894
M. Hoffmann, V.C. Hass, B. Frahm, J.-O. Schwabe, R. Pörtner, P. Lane, A. Munack, Untersuchung verschiedener mathematischer Modelle in Hinblick auf ihre Eignung für die adaptive Prozessführung von Hybridoma Zellkulturen, 2001.
ELSA
 
[7]
2001 | Konferenz - Vortrag | ELSA-ID: 2895
B. Frahm, R. Pörtner, Arbeitsschwerpunkte TUHH, Bioprozess- und Bioverfahrenstechnik, Arbeitsgruppe Zellkulturtechnik, 2001.
ELSA
 
[6]
2001 | Konferenz - Poster | ELSA-ID: 2960
B. Frahm, H. Atzert, J.-O. Schwabe, P. Lane, A. Munack, M. Hoffmann, V.C. Hass, R. Pörtner, Adaptive modellgestützte Steuerung von Zellkulturprozessen, 2001.
ELSA
 
[5]
2001 | Konferenz - Poster | ELSA-ID: 2961
P. Lane, B. Frahm, H. Atzert, J.-O. Schwabe, M. Hoffmann, V.C. Hass, R. Pörtner, Design of Feeding Strategies for Fed-Batch Cultures of Animal Cells by the Method of Inequalities, 2001.
ELSA
 
[4]
2001 | Konferenz - Poster | ELSA-ID: 2962
B. Frahm, H. Atzert, P. Lane, M. Hoffmann, V.C. Hass, A. Munack, R. Pörtner, Development of an automated, model-based, adaptive control for the effective cultivation of hybridoma cells, 2001.
ELSA
 
[3]
2001 | Konferenzband - Beitrag | ELSA-ID: 2963 | OA
V.C. Hass, P. Lane, M. Hoffmann, B. Frahm, J.-O. Schwabe, R. Pörtner, A. Munack, Model-Based Control of Hybridoma Cell Cultures, ScienceDirect, Oxford, 2001.
ELSA | DOI | Download (ext.)
 
[2]
2000 | Konferenz - Vortrag | ELSA-ID: 2893
T. Anderelei, B. Frahm, J. Büchs, Online-Bestimmung der Sauerstofftransferrate (OTR) und der Kohlendioxidtransferrate (CTR) in geschüttelten Bioreaktoren, 2000.
ELSA
 
[1]
2000 | Konferenz - Poster | ELSA-ID: 2959
M. Hoffmann, B. Frahm, J.-O. Schwabe, P. Lane, R. Pörtner, V.C. Hass, A. Munack, Modellgestützte Prozessführung für Hybridoma-Kulturen mit Hilfe des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus, 2000.
ELSA
 
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