Björn Frahm

Fachbereich 4 Life Science Technologies
bjoern.frahm@th-owl.de
ID
45666

168 Publikationen

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[168]
2024 | Konferenz - Vortrag | ELSA-ID: 12021
Segermann J, Luttmann M, Blome A, Feldt S, Sivanesan S, Holst CA, et al. Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie. 2024.
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[167]
2024 | Konferenz - Vortrag | ELSA-ID: 12022
Luttmann M, Blome A, Segermann J, Jekle M, Frahm B, Müller U. Erkenntnisse zur Nutzung von Photogrammmetrie für die Untersuchung des Bräunungsverhaltens von Weizenbrötchen. 2024.
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[166]
2024 | Konferenz - Poster | ELSA-ID: 12395
Müller C, Alarinta J, Frahm B, Wirtanen G. Investigation of microbial spoilage in vegan foods. 2024.
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[165]
2024 | Konferenz - Poster | ELSA-ID: 12396
Gassenmeier V, Campolongo G, Frahm B. Dissolved Carbon Dioxide in Addition to Dissolved Oxygen for In-situ Monitoring of Hybridoma Cell Culture. 2024.
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[164]
2024 | Konferenz - Poster | ELSA-ID: 12397
Blome A, Luttmann M, Segermann J, Jekle M, Frahm B, Müller U. Process optimization in baked goods production using inline sensors and objective product evaluation. 2024.
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[163]
2024 | Preprint | ELSA-ID: 12400 | OA
Ramm S, Odefey U, Frahm B, Pein-Hackelbusch M. Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters. bioRxiv; 2024.
ELSA | DOI | Download (ext.)
 
[162]
2024 | Konferenz - Poster | ELSA-ID: 10957
Reinhardt L, Gassenmeier V, Feldt S, Plate S, Tremmel M, Frahm B, et al. Mycelium-based materials from residues of the regional wood industry.
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[161]
2024 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 12402
Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. Chemie Ingenieur Technik. 2024;96(4):528–34.
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[160]
2023 | Konferenz - Poster | ELSA-ID: 11378
Gassenmeier V, Campolongo G, Frahm B. Real-time Monitoring of DCO2 in addition to DO.
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[159]
2023 | Konferenz - Poster | ELSA-ID: 11381
Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A systematic, model-based workflow for risk-based decision making in upstream development. DECHEMA e.V.;
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[158]
2023 | Konferenz - Poster | ELSA-ID: 11382 | OA
Gassenmeier V, Kuhfuß F, Deppe S, Ifrim G, Hernández Rodriguez T, Frahm B. View on a mechanistic model of Chlorella vulgaris in shake flasks.
ELSA | Download (ext.)
 
[157]
2023 | Konferenz - Vortrag | ELSA-ID: 11383
Hernández Rodriguez T, Posch C, Pörtner R, Lange-Hegermann M, Wurm FM, Frahm B. Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture. DECHEMA e.V.; 2023.
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[156]
2023 | Konferenzband - Beitrag | ELSA-ID: 11384 | OA
Müller C, Alarinta J, Frahm B, Wirtanen G. Microbial spoilage in vegan foods. Proceedings of the 10th International Congress of Food Technologists, Biotechnologists and Nutritionists: Smart Food for a Healthy Planet and Human Prosperity. Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draženka Komes, Sanja Vidaček Filipec and Bojana Voučko; 2023.
ELSA | Download (ext.)
 
[155]
2023 | Konferenz - Poster | ELSA-ID: 11487 | OA
Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression . DECHEMA e.V.;
ELSA | Download (ext.)
 
[154]
2023 | Konferenz - Poster | ELSA-ID: 10201 | OA
Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A systematic, model-based workflow for risk-based decision making in upstream development. 2023.
ELSA | Download (ext.)
 
[153]
2023 | Konferenz - Vortrag | ELSA-ID: 11109
Blome A, Luttmann M, Jekle M, Frahm B, Müller U. Untersuchung der räumlichen Verteilung von viskoelastischen Kenngrößen während der Weizenteigbereitung. 2023.
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[152]
2023 | Konferenz - Poster | ELSA-ID: 11110
Blome A, Luttmann M, Segermann J, Jekle M, Frahm B, Müller U. Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung. 2023.
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[151]
2023 | Konferenz - Poster | ELSA-ID: 12483
Blome A, Luttmann M, Segermann J, Jekle M, Frahm B, Müller U. Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung. 2023.
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[150]
2023 | Konferenz - Poster | ELSA-ID: 12485
Luttmann M, Blome A, Jekle M, Frahm B, Müller U. Teig 4.0 - Promotionsthemen. 2023.
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[149]
2023 | Konferenzband - Beitrag | ELSA-ID: 10788 | OA
Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. Jasperneite J, Wisniewski L, Fung Man K, Institute of Electrical and Electronics Engineers , editors. 2023 IEEE 21st International Conference on Industrial Informatics (INDIN). [Piscataway, NJ]: IEEE; 2023.
ELSA | DOI | Download (ext.)
 
[148]
2023 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11385
Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. Chemie Ingenieur Technik. 2023;95(12):1960–9.
ELSA | DOI | WoS
 
[147]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11377
Hernández Rodriguez T, Sekulic A, Lange-Hegermann M, Frahm B. Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. Processes. 2022;10(5).
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[146]
2022 | Konferenz - Poster | ELSA-ID: 7932
Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A systematic, model-based workflow for risk-based decision making in upstream development.
ELSA
 
[145]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7976
Gassenmeier V, Deppe S, Hernández Rodriguez T, Kuhfuß F, Moser A, Hass VC, et al. Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. Current Research in Biotechnology. 2022;4:102–19.
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[144]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7977
Kuhfuß F, Gassenmeier V, Deppe S, Ifrim GA, Hernández Rodriguez T, Frahm B. View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. Bioprocess and Biosystems Engineering. 2022;45:15–30.
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[143]
2022 | Datenpublikation | ELSA-ID: 10190
Gassenmeier V, Frahm B. Real-time Monitoring of DCO2 in addition to DO. assets-labs; 2022.
ELSA | Dateien verfügbar
 
[142]
2022 | Sammelwerk - Beitrag | ELSA-ID: 10193
Hernández Rodriguez T, Sekulic A, Lange-Hegermann M, Frahm B. Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In: Pörtner R, Möller J, editors. Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing. Basel: MDPI; 2022. p. 21–48. (Processes : open access journal; vol. special issue).
ELSA | DOI
 
[141]
2022 | Konferenzband - Beitrag | ELSA-ID: 10195
Blome A, Luttmann M, Segermann J, Jekle M, Frahm B, Müller U. Process optimisation in the field of wheat dough processing using real-time recording of quality-relevant characteristics in raw materials, intermediates and final products. Proceedings of the 33rd VH Yeast Conference 2022: Advances in Applied Research & Industrial Production of Baker’s Yeast, “100th anniversary of VH Berlin & Yeast(s) as an alternative protein source.” Versuchsanstalt der Hefeindustrie e.V.; 2022.
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[140]
2022 | Konferenz - Vortrag | ELSA-ID: 10196
Blome A, Luttmann M, Segermann J, Jekle M, Frahm B, Müller U. Process optimisation in the field of wheat dough processing using real-time recording of quality-relevant characteristics in raw materials, intermediates and final products. 2022.
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[139]
2022 | Konferenz - Vortrag | ELSA-ID: 10197
Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture. ACHEMA 2022. 2022.
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[138]
2022 | Konferenz - Poster | ELSA-ID: 10198
Hernández Rodriguez T, Pörtner R, Lange-Hegermann M, Wurm FM, Frahm B. A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion.
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[137]
2022 | Konferenz - Poster | ELSA-ID: 10199 | OA
Müller C, Alarinta J, Frahm B, Wirtanen G. Microbial spoilage in vegan foods. PBN 2022 Congress. 2022.
ELSA | Download (ext.)
 
[136]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11376
Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. Processes. 2021;9(6).
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[135]
2021 | Konferenz - Vortrag | ELSA-ID: 7927
Hernández Rodriguez T, Frahm B. Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction. 2021.
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[134]
2021 | Konferenz - Poster | ELSA-ID: 7931
Moser A, Möller J, Kuchemüller KB, Deppe S, Hernández Rodriguez T, Gassenmeier V, et al. Model-assisted Design of Experiments - Concept, Software and Applications. 2021.
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[133]
2021 | Lexikoneintrag | ELSA-ID: 7939
Wirtanen G, Alarinta J, Frahm B, Fasse S. Bovine Colostrum for Human Consumption. In: MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science. 2021.
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[132]
2021 | Sammelwerk - Beitrag | ELSA-ID: 7983
Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing. Basel: MDPI; 2021. p. 49–74. (Processes : open access journal ; vol. special issue).
ELSA | DOI
 
[131]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering. 2021;44(4):793–808.
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[130]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7986
Moser A, Kuchemüller KB, Deppe S, Hernández Rodriguez T, Frahm B, Pörtner R, et al. Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering. 2021;44(4):683–700.
ELSA | DOI
 
[129]
2021 | Konferenz - Vortrag | ELSA-ID: 8078
Blome A, Luttmann M, Frahm B, Müller U. Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung. Seminar Life Science Technologies 2021-04-28. 2021.
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[128]
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
Hernández Rodriguez T, Frahm B. Digital Seed Train Twins and Statistical Methods. In: Herwig C, Pörtner R, Möller J, editors. Digital Twins Tools and Concepts for Smart Biomanufacturing. Berlin, Heidelberg: Springer; 2021. p. 97–131. (Advances in Biochemical Engineering/Biotechnology; vol. 176).
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[127]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7981
Fasse S, Alarinta J, Frahm B, Wirtanen G. Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing. Dairy. 2021;2(4):556–75.
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[126]
2020 | Konferenz - Poster | ELSA-ID: 7929
Hernández Rodriguez T, Deppe S, Gassenmeier V, Kuhfuß F, Tölle M, Ifrim GA, et al. Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. 2020.
ELSA
 
[125]
2020 | Konferenz - Poster | ELSA-ID: 7930
Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. 2020.
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[124]
2020 | Konferenz - Vortrag | ELSA-ID: 7936
Hernández Rodriguez T, Frahm B, Posch C. Integration of prior knowledge and digital tools for uncertainty-based decision support. 2020.
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[123]
2020 | Konferenzband - Beitrag | ELSA-ID: 7937
Hernández Rodriguez T, Deppe S, Gassenmeier V, Kuhfuß F, Tölle M, Ifrim GA, et al. Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020. Wiley; 2020. (Volume 92; vol. No. 9).
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[122]
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020. Wiley; 2020. (Volume 92; vol. No. 9).
ELSA | DOI
 
[121]
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
Hernández Rodriguez T, Posch C, Schmutzhard J, Stettner J, Weihs Claus , Pörtner R, et al. Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach. Vol. 14, BMC Proceedings. BioMed Central; 2020.
ELSA | Dateien verfügbar | DOI
 
[120]
2020 | Konferenz - Poster | ELSA-ID: 3007
Kuhfuß F, Tölle M, Hernández Rodriguez T, Gassenmeier V, Deppe S, Ifrim GA, et al. Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. 2020.
ELSA
 
[119]
2020 | Konferenz - Poster | ELSA-ID: 3008
Deppe S, Kuhfuß F, Tölle M, Hernández Rodriguez T, Gassenmeier V, Ifrim GA, et al. Model-assisted Design of Experiments for algae cultivation. 2020.
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[118]
2020 | Konferenz - Poster | ELSA-ID: 3009
Ifrim GA, Deppe S, Hernández Rodriguez T, Gassenmeier V, Frahm B. Modeling of microalgae in an air-lift photobioreactor for biomass production. 2020.
ELSA
 
[117]
2020 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2392
Möller J, Hernández Rodríguez T, Müller J, Arndt L, Kuchemüller KB, Frahm B, et al. Model uncertainty-based evaluation of process strategies during scale-up of biopharmaceutical processes. Computers & Chemical Engineering. 2020;134:1–13.
ELSA | DOI
 
[116]
2020 | Sammelwerk - Beitrag | ELSA-ID: 2397
Hernández Rodríguez T, Frahm B. Design, Optimization and Adaptive Control of Cell Culture Seed Trains. In: Pörtner R, editor. Animal Cell Biotechnology - Methods and Protocols. Berlin, Heidelberg, New York: Springer; 2020. p. 251–67. (Methods in Molecular Biology; vol. 2095).
ELSA | DOI
 
[115]
2020 | Sammelwerk - Beitrag | ELSA-ID: 2399
Deppe S, Frahm B, Hass VC, Hernández Rodríguez T, Kuchemüller KB, Möller J, et al. Estimation of Process Model Parameters. In: Pörtner R, editor. Animal Cell Biotechnology: Methods and Protocols. Berlin ; Heidelberg ; New York: Springer; 2020. p. 213–34. (Methods in Molecular Biology; vol. 2095).
ELSA | DOI
 
[114]
2019 | Konferenz - Vortrag | ELSA-ID: 7928
Frahm B. Scale-up of stirred vessels. 2019.
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[113]
2019 | Konferenz - Vortrag | ELSA-ID: 2956
Möller J, Müller J, Hernández Rodriguez T, Kuchemüller KB, Arndt L, Frahm B, et al. Workflow for model-assisted design and scale-up of biopharmaceutical production processes. 2019.
ELSA
 
[112]
2019 | Konferenz - Vortrag | ELSA-ID: 2957
Möller J, Kuchemüller KB, Moser A, Hass VC, Hernández Rodriguez T, Deppe S, et al. Model-Assisted Design of Experiments. 2019.
ELSA
 
[111]
2019 | Konferenz - Vortrag | ELSA-ID: 2958
Ifrim GA, Titica M, Deppe S, Frahm B, Barbu M, Caraman S. Novel control strategy for microalgae in photobioreactor. 2019.
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[110]
2019 | Konferenz - Poster | ELSA-ID: 3000
Hernández Rodriguez T, Posch C, Schmutzhard J, Stettner J, Weihs J, Pörtner R, et al. Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. 2019.
ELSA
 
[109]
2019 | Konferenz - Poster | ELSA-ID: 3001
Hernández Rodriguez T, Posch C, Schmutzhard J, Stettner J, Weihs J, Pörtner R, et al. Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. 2019.
ELSA
 
[108]
2019 | Konferenz - Poster | ELSA-ID: 3002
Möller J, Kuchemüller KB, Hernández Rodriguez T, Deppe S, Ifrim GA, Moser A, et al. Model-Assisted Design of Experiments – Software Toolbox. 2019.
ELSA
 
[107]
2019 | Konferenz - Poster | ELSA-ID: 3003
Deppe S, Hernández Rodriguez T, Gassenmeier V, Tölle M, Kuhfuß F, Möller J, et al. Model-assisted Design of Experiments for algae cultivation. 2019.
ELSA
 
[106]
2019 | Konferenz - Poster | ELSA-ID: 3004
Ifrim GA, Deppe S, Hernández Rodriguez T, Gassenmeier V, Frahm B. Modeling of microalgae in an air-lift photobioreactor for biomass production. 2019.
ELSA
 
[105]
2019 | Konferenz - Poster | ELSA-ID: 3005
Hernández Rodriguez T, Posch C, Schmutzhard J, Stettner J, Weihs J, Pörtner R, et al. Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. 2019.
ELSA
 
[104]
2019 | Konferenz - Poster | ELSA-ID: 3006
Ifrim GA, Titica M, Deppe S, Frahm B, Barbu M, Caraman S. Multivariable control strategy for the photosynthetic cultures of microalgae. 2019.
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[103]
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 | OA
Hernández Rodriguez T, Posch C, Schmutzhard J, Stettner J, Weihs C, Pörtner R, et al. Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method. Biotechnology and Bioengineering. 2019;116(11):2944–59.
ELSA | DOI | Download (ext.)
 
[102]
2019 | Konferenzband - Beitrag | ELSA-ID: 2400
Ifrim GA, Titica M, Deppe S, Frahm B, Barbu M, Caraman S. Multivariable control strategy for the photosynthetic cultures of microalgae. 2019 23rd International Conference on System Theory, Control and Computing (ICSTCC). IEEE; 2019.
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[101]
2018 | Konferenz - Vortrag | ELSA-ID: 7935
Hernández Rodriguez T, Frahm B, Posch C, Schmutzhard J, Stettner J. A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization. 2018.
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[100]
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
Hernández Rodriguez T, Krull S, Hass VC, Möller J, Pörtner R, Frahm B. Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. Vol. 112, BMC Proceedings. BioMed Central; 2018.
ELSA | Dateien verfügbar | DOI
 
[99]
2018 | Konferenz - Vortrag | ELSA-ID: 2955
Pörtner R, Möller J, Frahm B, Hass VC. Model-Assisted Design of Process Strategies for Cell Culture Processes. 2018.
ELSA
 
[98]
2018 | Konferenz - Poster | ELSA-ID: 2997
Möller J, Kuchemüller KB, Freiberger F, Levermann P, Hernández Rodriguez T, Frahm B, et al. Model-Assisted Design and Optimization of Process Strategies. 2018.
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[97]
2018 | Konferenz - Poster | ELSA-ID: 2999
Hernández Rodriguez T, Möller J, Kuchemüller KB, Freiberger F, Levermann P, Hass VC, et al. Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses. 2018.
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[96]
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 | OA
Möller J, Kuchemüller KB, Hernández Rodriguez T, Frahm B, Hass VC, Pörtner R. Model-Assisted Design of Process Strategies for Cell Culture Processes. American Pharmaceutical Review. 2018;3:39–41.
ELSA | Download (ext.)
 
[95]
2017 | Konferenz - Vortrag | ELSA-ID: 2920
Hernández Rodriguez T, Kern S, Platas Barradas O, Pörtner R, Frahm B. Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. 2017.
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[94]
2017 | Konferenz - Vortrag | ELSA-ID: 2921
Pörtner R, Möller J, Hernández Rodriguez T, Frahm B, Hass VC. Model-assisted design and optimization of biotechnological processes. 2017.
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[93]
2017 | Konferenz - Vortrag | ELSA-ID: 2950
Hernández Rodriguez T, Koopmann KS, Klaes J, Kern S, Platas Barradas O, Pörtner R, et al. Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. 2017.
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[92]
2017 | Konferenz - Poster | ELSA-ID: 2994
Hernández Rodriguez T, Koopmann KS, Pörtner R, Frahm B. Influence of parameter accuracies in cell culture seed train simulations. 2017.
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[91]
2017 | Konferenz - Poster | ELSA-ID: 2995
Hernández Rodriguez T, Krull S, Hass VC, Möller J, Pörtner R, Frahm B. Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. 2017.
ELSA
 
[90]
2017 | Konferenz - Poster | ELSA-ID: 2996
Hernández Rodriguez T, Krull S, Hass VC, Pörtner R, Frahm B. Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. 2017.
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[89]
2016 | Konferenz - Poster | ELSA-ID: 2991
Beshay U, Feldt S, Schwarze B, Wefing P, Hahne T, Moschinski J, et al. DMA Photobioreactor System – Cultivation at low shear stress and optional membrane aeration. 2016.
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[88]
2016 | Konferenz - Poster | ELSA-ID: 2992
Hernández Rodriguez T, Vörtler S, Kern S, Platas Barradas O, Pörtner R, Frahm B. A software tool for biopharmaceutical seed train design and optimization. 2016.
ELSA
 
[87]
2016 | Konferenz - Poster | ELSA-ID: 2993
Koopmann KS, Hernández Rodriguez T, Vörtler S, Beshay U, Möller J, Pörtner R, et al. Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies. 2016.
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[86]
2016 | Sammelwerk - Beitrag | ELSA-ID: 2395
Pörtner R, Platas Barradas O, Frahm B, Hass VC. Advanced Process and Control Strategies for Bioreactors. In: Current Developments in Biotechnology and Bioengineering: Bioprocesses, Bioreactors and Controls. Amsterdam: Elsevier; 2016. p. 463–93.
ELSA | DOI
 
[85]
2015 | Konferenzband - Beitrag | ELSA-ID: 2819 | OA
Hernández Rodriguez T, Pörtner R, Frahm B. Considerations for cell passaging in cell culture seed trains. Vol. 9, BMC proceedings / BioMed Central. BioMed Central; 2015.
ELSA | DOI | Download (ext.)
 
[84]
2015 | Konferenzband - Beitrag | ELSA-ID: 2820 | OA
Kern S, Platas Barradas O, Schaletzky M, Sandig V, Frahm B, Pörtner R. Model-based strategy for cell culture seed train layout verified at lab scale. Vol. 9, BMC proceedings / BioMed Central. BioMed Central; 2015.
ELSA | DOI | Download (ext.)
 
[83]
2015 | Konferenz - Vortrag | ELSA-ID: 2917
Frahm B, Pörtner R, Kern S, Hernández Rodriguez T. Seed train design and optimization for animal cell suspension culture. 2015.
ELSA | Dateien verfügbar
 
[82]
2015 | Konferenz - Vortrag | ELSA-ID: 2919
Frahm B, Hernández Rodriguez T, Kern S, Koopmann KS, Beshay U, Platas-Barradas O, et al. Seed train design and optimization for animal cell suspension culture. 2015.
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[81]
2015 | Konferenz - Poster | ELSA-ID: 2985
Hernández Rodriguez T, Pörtner R, Frahm B. Considerations for cell passaging in cell culture seed trains. 2015.
ELSA
 
[80]
2015 | Konferenz - Poster | ELSA-ID: 2986
Kern S, Platas O, Schaletzky M, Sandig V, Frahm B, Pörtner R. Model-based strategy for cell culture seed train layout verified at lab scale. 2015.
ELSA
 
[79]
2015 | Konferenz - Poster | ELSA-ID: 2987
Hernández Rodriguez T, Pörtner R, Frahm B. A software tool for biopharmaceutical seed train design and optimization. 2015.
ELSA
 
[78]
2015 | Konferenz - Poster | ELSA-ID: 2988
Hernández Rodriguez T, Pörtner R, Frahm B. Considerations for cell passaging in cell culture seed trains. 2015.
ELSA
 
[77]
2015 | Konferenz - Poster | ELSA-ID: 2990
Kern S, Platas O, Schaletzky M, Sandig V, Frahm B, Pörtner R. Model-based strategy for cell culture seed train layout verified at lab scale. 2015.
ELSA
 
[76]
2015 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2389
Kern S, Platas-Barradas O, Pörtner R, Frahm B. Model-based strategy for cell culture seed train layout verified at lab scale. Cytotechnology. 2015;68(4):1019–32.
ELSA | DOI | Download (ext.)
 
[75]
2014 | Patent | ELSA-ID: 2878
Frahm B, Meier U. Beleuchtung von disposable Bioreaktoren. 2014.
ELSA
 
[74]
2014 | Konferenz - Poster | ELSA-ID: 2984
Drews F, Drews G, Folz C, Platz G, Gassenmeier T, Kramer M, et al. Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche. 2014.
ELSA
 
[73]
2014 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2388
Hahne T, Schwarze B, Kramer M, Frahm B. Disposable algae cultivation for high-value products using all around LED-illumination directly on the bags. Journal of Algal Biomass Utilization. 2014;5(2):66–73.
ELSA
 
[72]
2013 | Konferenzband - Beitrag | ELSA-ID: 2817 | OA
Hernández Rodriguez T, Pörtner R, Frahm B. Seed train optimization for suspension cell culture. Vol. 7, BMC proceedings / BioMed Central . BioMed Central ; 2013.
ELSA | DOI | Download (ext.)
 
[71]
2013 | Konferenzband - Beitrag | ELSA-ID: 2818 | OA
Kern S, Platas O, Schaletzky M, Sandig V, Frahm B, Pörtner R. Model-based design of the first steps of a seed train for cell culture processes. Vol. 7, BMC proceedings / BioMed Central . BioMed Central; 2013.
ELSA | DOI | Download (ext.)
 
[70]
2013 | Konferenz - Poster | ELSA-ID: 2980
Kern S, Platas O, Schaletzky M, Sandig V, Frahm B, Pörtner R. Modellgestützte Auslegung der ersten Schritte eines Seed-Trains für Zellkulturprozesse. 2013.
ELSA
 
[69]
2013 | Konferenz - Poster | ELSA-ID: 2981
Kern S, Platas O, Schaletzky M, Sandig V, Frahm B, Pörtner R. Model-based design of the first steps of a seed train for cell culture processes. 2013.
ELSA
 
[68]
2013 | Konferenz - Poster | ELSA-ID: 2982
Hahne T, Schwarze B, Moschinski J, Kuttig A, Kramer M, Frahm B. Disposable Algenkultivierung für hochpreisige Produkte mittels LED-Rundumbeleuchtung direkt auf den Bags. 2013.
ELSA
 
[67]
2013 | Konferenz - Poster | ELSA-ID: 2983
Hernández Rodriguez T, Pörtner R, Frahm B. Seed train optimization for suspension cell culture. 2013.
ELSA
 
[66]
2013 | Sammelwerk - Beitrag | ELSA-ID: 10214
Frahm B. Seed Train Optimization for Cell Culture. In: Pörtner R, editor. Animal Cell Biotechnology - Methods and Protocols. 3rd ed. Totowa, NJ: Humana Press; 2013. p. 355–67. (Methods in Molecular Biology; vol. 1104).
ELSA | DOI
 
[65]
2012 | Konferenzband - Beitrag | ELSA-ID: 2816 | OA
Frahm B, Brod H. Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA). Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009. Dordrecht: Springer; 2012. (ESACT Proceedings; vol. 5).
ELSA | DOI | Download (ext.)
 
[64]
2012 | Patent | ELSA-ID: 2877
Brod H, Frahm B. Photobioreaktor mit rotatorisch oszillierenden Lichtquellen. 2012.
ELSA
 
[63]
2012 | Konferenz - Vortrag | ELSA-ID: 2918
Van Hecke W, Haltrich D, Frahm B, Brod H, Ludwig R. Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. Achema 2012. Vogel Business Media; 2012.
ELSA
 
[62]
2012 | Konferenz - Poster | ELSA-ID: 2973
Marzougui R, Pörtner R, Frahm B. Optimierung des Seed trains von Suspensions-Zellkulturen. 2012.
ELSA
 
[61]
2011 | Patent | ELSA-ID: 2876
Brod H, Frahm B, Jenne M, Kauling J, Schmitt F, Seletzky J. Flüssigkeitsbegaser. 2011.
ELSA
 
[60]
2011 | Konferenz - Poster | ELSA-ID: 2972
Van Hecke W, Haltrich D, Frahm B, Brod H, Ludwig R. Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. 2011.
ELSA
 
[59]
2011 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2350
Van Hecke W, Haltrich D, Frahm B, Brod H, Dewulf J, Van Langenhove H, et al. A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor. Journal of Molecular Catalysis B: Enzymatic. 2011;68(2):154–61.
ELSA | DOI | Download (ext.)
 
[58]
2010 | Konferenzband - Beitrag | ELSA-ID: 2815
Dercks B, Frahm B, Grünewald M, Kenig E, Lautenschleger A, Gorak A, et al. Intensified absorption and distillation devices for modular chemical production processes. Proceedings 19th International Congress of Chemical and Process Engineering. Czech Society of Chemical Engineering; 2010.
ELSA
 
[57]
2010 | Patent | ELSA-ID: 2873
Brod H, Frahm B, Kauling J. Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen. 2010.
ELSA
 
[56]
2010 | Patent | ELSA-ID: 2874
Brod H, Frahm B, Jenne M, Kauling J. Bioreaktor. 2010.
ELSA
 
[55]
2010 | Patent | ELSA-ID: 2875
Frahm B, Kauling J, Pütz A, Schindler M. Begasungssystem. 2010.
ELSA
 
[54]
2010 | Konferenz - Vortrag | ELSA-ID: 2892
Frahm B, Brod H. Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration. 2010.
ELSA
 
[53]
2010 | Konferenz - Vortrag | ELSA-ID: 2913
Dercks B, Frahm B, Grünewald M, Kenig E, Lautenschleger A, Gorak A, et al. Intensified absorption and distillation devices for modular chemical production processes. 2010.
ELSA
 
[52]
2009 | Patent | ELSA-ID: 2872
Braun A, Brod H, Frahm B, Jenne M, Kauling J, Kirchner S. Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen. 2009.
ELSA
 
[51]
2009 | Konferenz - Vortrag | ELSA-ID: 2912
Frahm B, Brod H, Langer U. Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA). 2009.
ELSA
 
[50]
2009 | Konferenz - Poster | ELSA-ID: 2970
Frahm B, Brod H, Langer U. Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA). 2009.
ELSA
 
[49]
2009 | Konferenz - Poster | ELSA-ID: 2971
Van Hecke W, Van Langenhovve H, Frahm B, Brod H, Dewulf J, Haltrich D, et al. Upscaling the biocatalytic conversion of lactose to lactobionic acid with the dynamic membrane aeration reactor. 2009.
ELSA
 
[48]
2009 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2349 | OA
Frahm B, Brod H, Langer U. Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration. Cytotechnology. 2009;59(1):17–30.
ELSA | DOI | Download (ext.)
 
[47]
2008 | Konferenz - Vortrag | ELSA-ID: 2911
Brod H, Kauling J, Frahm B, Jenne M, Langer U, Bödeker B. Pushing the Limits in High-Density Mammalian Cell Fermentation. 2008.
ELSA
 
[46]
2008 | Konferenz - Poster | ELSA-ID: 2968
Frahm B, Brod H, Burnett M, Langer U, Bödeker B. High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA). 2008.
ELSA
 
[45]
2008 | Konferenz - Poster | ELSA-ID: 2969
Frahm B, Brod H. High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA). 2008.
ELSA
 
[44]
2007 | Konferenzband - Beitrag | ELSA-ID: 2814
Pörtner R, Frahm B, Lane P, Munack A, Kühn K, Hass VC. Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller. Cell Technology for Cell Products. Dordrecht: Springer; 2007. (ESACT Proceedings; vol. 3).
ELSA | DOI
 
[43]
2007 | Patent | ELSA-ID: 2870 | OA
Brod H, Frahm B, Kauling J, Rose R. Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component. 2007.
ELSA | Download (ext.)
 
[42]
2007 | Patent | ELSA-ID: 2871
Brod H, Frahm B, Kauling J, Poggel M, Rose R, Schmidt S. Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen. 2007.
ELSA
 
[41]
2007 | Konferenz - Vortrag | ELSA-ID: 2909
Brod H, Frahm B, Kauling J. Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. 2007.
ELSA
 
[40]
2007 | Konferenz - Vortrag | ELSA-ID: 2910
Brod H, Frahm B, Kauling J. Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. 2007.
ELSA
 
[39]
2007 | Konferenz - Poster | ELSA-ID: 2967
Frahm B, Kirchner S, Rose R, Jenne M, Kauling J, Brod H, et al. High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA). 2007.
ELSA
 
[38]
2007 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2348
Frahm B, Kirchner S, Kauling J, Brod H, Langer U, Bödeker B. Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien. Chemie Ingenieur Technik. 2007;79(7):1052–8.
ELSA | DOI | Download (ext.)
 
[37]
2005 | Konferenzband - Beitrag | ELSA-ID: 2813
Frahm B, Pörtner R. Flexible Fed-Batch Process Control of Animal Cells. Animal Cell Technology Meets Genomics. Dordrecht: Springer; 2005. (ESACT Proceedings; vol. 2).
ELSA | DOI
 
[36]
2005 | Konferenz - Vortrag | ELSA-ID: 2907
Pörtner R, Frahm B, Lane P, Munack A. Optimisation of time-space-yield for hybridoma fed-batch cultures with an adaptive OLFO-controller. 2005.
ELSA
 
[35]
2005 | Konferenz - Vortrag | ELSA-ID: 2908
Pörtner R, Frahm B, Hass VC, Lane P, Munack A. Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. 2005.
ELSA
 
[34]
2005 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2347 | OA
Frahm B, Lane P, Munack A, Pörtner R. Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. Chemie Ingenieur Technik. 2005;77(4):429–35.
ELSA | DOI | Download (ext.)
 
[33]
2004 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2345 | OA
Pörtner R, Schwabe J-O, Frahm B. Evaluation of selected control strategies for fed-batch cultures of a hybridoma cell line. Biotechnology and Applied Biochemistry. 2004;40.
ELSA | DOI | Download (ext.)
 
[32]
2003 | Konferenz - Vortrag | ELSA-ID: 7934
Frahm B, Pörtner R. Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies. 2003.
ELSA
 
[31]
2003 | Konferenzband - Beitrag | ELSA-ID: 2435
Frahm B, Müller-Landré B, Wiggers de Almeida G, Singer M, Rausch M, Lane P, et al. Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control. Beckmann D, Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld), editors. Technische Systeme für Biotechnologie und Umwelt. Heiligenstadt: Inst. für Bioprozess- und Analysenmesstechnik ; 2003.
ELSA
 
[30]
2003 | Konferenzband - Beitrag | ELSA-ID: 2436
Kühn K, Frahm B, Pörtner R, Lane P, Munack A, Hass VC. Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells. European Federation of Chemical Engineering, editor. Vol. 10, ECCE - 4th European Congress of Chemical Engineering. Granada: ECCE4; 2003.
ELSA
 
[29]
2003 | Konferenz - Vortrag | ELSA-ID: 2902
Frahm B, Pörtner R. Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung. 2003.
ELSA
 
[28]
2003 | Konferenz - Vortrag | ELSA-ID: 2903
Hass VC, Kühn K, Frahm B, Pörtner R, Lane P, Munack A. Ein strukturiertes Kompartiment-Modell zur Beschreibung der Kultivierung von Hybridomazellen als Teil einer adaptiven, modellgestützten Prozessführung. 2003.
ELSA
 
[27]
2003 | Konferenz - Vortrag | ELSA-ID: 2905
Frahm B, Lane P, Munack A, Hass VC, Pörtner R. Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies. 2003.
ELSA | Dateien verfügbar
 
[26]
2003 | Konferenz - Vortrag | ELSA-ID: 2906
Pörtner R, Frahm B, Lane P, Hass VC, Munack A, Märkl H. Fed-Batch-Kultivierung tierischer Zellen – eine Herausforderung für eine adaptive, modellgestützte Steuerung. 2003.
ELSA
 
[25]
2003 | Konferenz - Poster | ELSA-ID: 2964
Frahm B, Pörtner R. CO2-off-gas measurement for animal cell culture processes. 2003.
ELSA
 
[24]
2003 | Konferenz - Poster | ELSA-ID: 2965
Frahm B, Pörtner R. Flexible fed-batch process control of animal cells. 2003.
ELSA
 
[23]
2003 | Konferenz - Poster | ELSA-ID: 2966
Kühn K, Frahm B, Pörtner R, Lane P, Munack A, Hass VC. Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells. 2003.
ELSA
 
[22]
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2343 | OA
Frahm B, Hass VC, Lane P, Munack A, Märkl H, Pörtner R. Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung. Chemie Ingenieur Technik. 2003;75(4):457–60.
ELSA | DOI | Download (ext.)
 
[21]
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2344 | OA
Frahm B, Lane P, Märkl H, Pörtner R. Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis. Bioprocess and Biosystems Engineering. 2003;26(1):1–10.
ELSA | DOI | Download (ext.)
 
[20]
2003 | Dissertation | ELSA-ID: 2393
Frahm B. Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Norderstedt: Books on Demand GmbH; 2003. 120 p.
ELSA
 
[19]
2002 | Konferenzband - Beitrag | ELSA-ID: 2431
Frahm B, Pörtner R. Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen. Kaden H, Forum Innovative Biosystemtechnik - Sensorik, Aktorik und Auswertung Biotechnologischer Prozesse (2001 : Waldheim), editors. Biosystemtechnik: Innovative Biosystemtechnik - Sensorik, Aktorik und Auswertung biotechnologischer Prozesse. Meinsberg : Kurt-Schwabe-Inst. ; 2002.
ELSA
 
[18]
2002 | Konferenz - Vortrag | ELSA-ID: 2897
Frahm B, Pörtner R. Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen. 2002.
ELSA
 
[17]
2002 | Konferenz - Vortrag | ELSA-ID: 2898
Frahm B, Pörtner R. Adaptive, model-based control by the OLFO-controller for the fed-batch cultivation of animal cells. 2002.
ELSA
 
[16]
2002 | Konferenz - Vortrag | ELSA-ID: 2899
Frahm B, Pörtner R. Adaptive, model-based control by the OLFO-controller for the fed-batch cultivation of animal cells. 2002.
ELSA
 
[15]
2002 | Konferenz - Vortrag | ELSA-ID: 2900
Frahm B, Müller-Landré B, Wiggers de Almeida G, Singer M, Rausch M, Lane P, et al. Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control. 2002.
ELSA
 
[14]
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2340 | OA
Frahm B, Blank H-C, Cornand P, Oelßner W, Guth U, Lane P, et al. Determination of dissolved CO2 concentration and CO2 production rate of mammalian cell suspension culture based on off-gas measurement. Journal of Biotechnology. 2002;99(2):133–48.
ELSA | DOI | Download (ext.)
 
[13]
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2341 | OA
Frahm B, Lane P, Atzert H, Munack A, Hoffmann M, Hass VC, et al. Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Effective Fed-Batch Cultivation of Hybridoma Cells. Biotechnology Progress. 2002;18(5):1095–103.
ELSA | DOI | Download (ext.)
 
[12]
2002 | Zeitschriftenaufsatz | ELSA-ID: 2342
Frahm B, Pörtner R. Reaktor-Abgasmessungen bei Zellkulturen. BIOforum. 2002;4:179–80.
ELSA
 
[11]
2001 | Konferenz - Vortrag | ELSA-ID: 7933
Frahm B, Pörtner R. Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen. 2001.
ELSA
 
[10]
2001 | Konferenzband - Beitrag | ELSA-ID: 2427
Frahm B, Atzert H, Lane P, Hoffmann M, Hass VC, Munack A, et al. Development of an Automated, Adaptive Model-Based Control for the Effective Cultivation of Hybridoma Cells. Animal Cell Technology: From Target to Market. Dordrecht: Springer; 2001. (ESACT Proceedings; vol. 1).
ELSA | DOI
 
[9]
2001 | Konferenz - Poster | ELSA-ID: 2429
Hass VC, Lane P, Hoffmann M, Frahm B, Schwabe J-O, Pörtner R, et al. Model-Based Control of Hybridoma Cell Cultures. 2001.
ELSA
 
[8]
2001 | Konferenz - Vortrag | ELSA-ID: 2894
Hoffmann M, Hass VC, Frahm B, Schwabe J-O, Pörtner R, Lane P, et al. Untersuchung verschiedener mathematischer Modelle in Hinblick auf ihre Eignung für die adaptive Prozessführung von Hybridoma Zellkulturen. 2001.
ELSA
 
[7]
2001 | Konferenz - Vortrag | ELSA-ID: 2895
Frahm B, Pörtner R. Arbeitsschwerpunkte TUHH, Bioprozess- und Bioverfahrenstechnik, Arbeitsgruppe Zellkulturtechnik. 2001.
ELSA
 
[6]
2001 | Konferenz - Poster | ELSA-ID: 2960
Frahm B, Atzert H, Schwabe J-O, Lane P, Munack A, Hoffmann M, et al. Adaptive modellgestützte Steuerung von Zellkulturprozessen. 2001.
ELSA
 
[5]
2001 | Konferenz - Poster | ELSA-ID: 2961
Lane P, Frahm B, Atzert H, Schwabe J-O, Hoffmann M, Hass VC, et al. Design of Feeding Strategies for Fed-Batch Cultures of Animal Cells by the Method of Inequalities. 2001.
ELSA
 
[4]
2001 | Konferenz - Poster | ELSA-ID: 2962
Frahm B, Atzert H, Lane P, Hoffmann M, Hass VC, Munack A, et al. Development of an automated, model-based, adaptive control for the effective cultivation of hybridoma cells. 2001.
ELSA
 
[3]
2001 | Konferenzband - Beitrag | ELSA-ID: 2963 | OA
Hass VC, Lane P, Hoffmann M, Frahm B, Schwabe J-O, Pörtner R, et al. Model-Based Control of Hybridoma Cell Cultures. Published for the International Federation of Automatic Control by Pergamon , editor. Computer Applications in Biotechnology, 2001: Modelling, Monitoring and Control of Biotechnological Processes. Oxford: ScienceDirect; 2001. (  IFAC Proceedings Volumes / IFAC, International Federation of Automatic Control; vol. 34).
ELSA | DOI | Download (ext.)
 
[2]
2000 | Konferenz - Vortrag | ELSA-ID: 2893
Anderelei T, Frahm B, Büchs J. Online-Bestimmung der Sauerstofftransferrate (OTR) und der Kohlendioxidtransferrate (CTR) in geschüttelten Bioreaktoren. 2000.
ELSA
 
[1]
2000 | Konferenz - Poster | ELSA-ID: 2959
Hoffmann M, Frahm B, Schwabe J-O, Lane P, Pörtner R, Hass VC, et al. Modellgestützte Prozessführung für Hybridoma-Kulturen mit Hilfe des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus. 2000.
ELSA
 
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[168]
2024 | Konferenz - Vortrag | ELSA-ID: 12021
Segermann J, Luttmann M, Blome A, Feldt S, Sivanesan S, Holst CA, et al. Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie. 2024.
ELSA
 
[167]
2024 | Konferenz - Vortrag | ELSA-ID: 12022
Luttmann M, Blome A, Segermann J, Jekle M, Frahm B, Müller U. Erkenntnisse zur Nutzung von Photogrammmetrie für die Untersuchung des Bräunungsverhaltens von Weizenbrötchen. 2024.
ELSA
 
[166]
2024 | Konferenz - Poster | ELSA-ID: 12395
Müller C, Alarinta J, Frahm B, Wirtanen G. Investigation of microbial spoilage in vegan foods. 2024.
ELSA
 
[165]
2024 | Konferenz - Poster | ELSA-ID: 12396
Gassenmeier V, Campolongo G, Frahm B. Dissolved Carbon Dioxide in Addition to Dissolved Oxygen for In-situ Monitoring of Hybridoma Cell Culture. 2024.
ELSA
 
[164]
2024 | Konferenz - Poster | ELSA-ID: 12397
Blome A, Luttmann M, Segermann J, Jekle M, Frahm B, Müller U. Process optimization in baked goods production using inline sensors and objective product evaluation. 2024.
ELSA
 
[163]
2024 | Preprint | ELSA-ID: 12400 | OA
Ramm S, Odefey U, Frahm B, Pein-Hackelbusch M. Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters. bioRxiv; 2024.
ELSA | DOI | Download (ext.)
 
[162]
2024 | Konferenz - Poster | ELSA-ID: 10957
Reinhardt L, Gassenmeier V, Feldt S, Plate S, Tremmel M, Frahm B, et al. Mycelium-based materials from residues of the regional wood industry.
ELSA
 
[161]
2024 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 12402
Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. Chemie Ingenieur Technik. 2024;96(4):528–34.
ELSA | DOI | WoS
 
[160]
2023 | Konferenz - Poster | ELSA-ID: 11378
Gassenmeier V, Campolongo G, Frahm B. Real-time Monitoring of DCO2 in addition to DO.
ELSA
 
[159]
2023 | Konferenz - Poster | ELSA-ID: 11381
Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A systematic, model-based workflow for risk-based decision making in upstream development. DECHEMA e.V.;
ELSA
 
[158]
2023 | Konferenz - Poster | ELSA-ID: 11382 | OA
Gassenmeier V, Kuhfuß F, Deppe S, Ifrim G, Hernández Rodriguez T, Frahm B. View on a mechanistic model of Chlorella vulgaris in shake flasks.
ELSA | Download (ext.)
 
[157]
2023 | Konferenz - Vortrag | ELSA-ID: 11383
Hernández Rodriguez T, Posch C, Pörtner R, Lange-Hegermann M, Wurm FM, Frahm B. Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture. DECHEMA e.V.; 2023.
ELSA
 
[156]
2023 | Konferenzband - Beitrag | ELSA-ID: 11384 | OA
Müller C, Alarinta J, Frahm B, Wirtanen G. Microbial spoilage in vegan foods. Proceedings of the 10th International Congress of Food Technologists, Biotechnologists and Nutritionists: Smart Food for a Healthy Planet and Human Prosperity. Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draženka Komes, Sanja Vidaček Filipec and Bojana Voučko; 2023.
ELSA | Download (ext.)
 
[155]
2023 | Konferenz - Poster | ELSA-ID: 11487 | OA
Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression . DECHEMA e.V.;
ELSA | Download (ext.)
 
[154]
2023 | Konferenz - Poster | ELSA-ID: 10201 | OA
Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A systematic, model-based workflow for risk-based decision making in upstream development. 2023.
ELSA | Download (ext.)
 
[153]
2023 | Konferenz - Vortrag | ELSA-ID: 11109
Blome A, Luttmann M, Jekle M, Frahm B, Müller U. Untersuchung der räumlichen Verteilung von viskoelastischen Kenngrößen während der Weizenteigbereitung. 2023.
ELSA
 
[152]
2023 | Konferenz - Poster | ELSA-ID: 11110
Blome A, Luttmann M, Segermann J, Jekle M, Frahm B, Müller U. Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung. 2023.
ELSA
 
[151]
2023 | Konferenz - Poster | ELSA-ID: 12483
Blome A, Luttmann M, Segermann J, Jekle M, Frahm B, Müller U. Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung. 2023.
ELSA
 
[150]
2023 | Konferenz - Poster | ELSA-ID: 12485
Luttmann M, Blome A, Jekle M, Frahm B, Müller U. Teig 4.0 - Promotionsthemen. 2023.
ELSA
 
[149]
2023 | Konferenzband - Beitrag | ELSA-ID: 10788 | OA
Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. Jasperneite J, Wisniewski L, Fung Man K, Institute of Electrical and Electronics Engineers , editors. 2023 IEEE 21st International Conference on Industrial Informatics (INDIN). [Piscataway, NJ]: IEEE; 2023.
ELSA | DOI | Download (ext.)
 
[148]
2023 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11385
Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. Chemie Ingenieur Technik. 2023;95(12):1960–9.
ELSA | DOI | WoS
 
[147]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11377
Hernández Rodriguez T, Sekulic A, Lange-Hegermann M, Frahm B. Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. Processes. 2022;10(5).
ELSA | DOI
 
[146]
2022 | Konferenz - Poster | ELSA-ID: 7932
Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A systematic, model-based workflow for risk-based decision making in upstream development.
ELSA
 
[145]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7976
Gassenmeier V, Deppe S, Hernández Rodriguez T, Kuhfuß F, Moser A, Hass VC, et al. Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. Current Research in Biotechnology. 2022;4:102–19.
ELSA | DOI
 
[144]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7977
Kuhfuß F, Gassenmeier V, Deppe S, Ifrim GA, Hernández Rodriguez T, Frahm B. View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. Bioprocess and Biosystems Engineering. 2022;45:15–30.
ELSA | DOI
 
[143]
2022 | Datenpublikation | ELSA-ID: 10190
Gassenmeier V, Frahm B. Real-time Monitoring of DCO2 in addition to DO. assets-labs; 2022.
ELSA | Dateien verfügbar
 
[142]
2022 | Sammelwerk - Beitrag | ELSA-ID: 10193
Hernández Rodriguez T, Sekulic A, Lange-Hegermann M, Frahm B. Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In: Pörtner R, Möller J, editors. Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing. Basel: MDPI; 2022. p. 21–48. (Processes : open access journal; vol. special issue).
ELSA | DOI
 
[141]
2022 | Konferenzband - Beitrag | ELSA-ID: 10195
Blome A, Luttmann M, Segermann J, Jekle M, Frahm B, Müller U. Process optimisation in the field of wheat dough processing using real-time recording of quality-relevant characteristics in raw materials, intermediates and final products. Proceedings of the 33rd VH Yeast Conference 2022: Advances in Applied Research & Industrial Production of Baker’s Yeast, “100th anniversary of VH Berlin & Yeast(s) as an alternative protein source.” Versuchsanstalt der Hefeindustrie e.V.; 2022.
ELSA
 
[140]
2022 | Konferenz - Vortrag | ELSA-ID: 10196
Blome A, Luttmann M, Segermann J, Jekle M, Frahm B, Müller U. Process optimisation in the field of wheat dough processing using real-time recording of quality-relevant characteristics in raw materials, intermediates and final products. 2022.
ELSA
 
[139]
2022 | Konferenz - Vortrag | ELSA-ID: 10197
Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture. ACHEMA 2022. 2022.
ELSA
 
[138]
2022 | Konferenz - Poster | ELSA-ID: 10198
Hernández Rodriguez T, Pörtner R, Lange-Hegermann M, Wurm FM, Frahm B. A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion.
ELSA
 
[137]
2022 | Konferenz - Poster | ELSA-ID: 10199 | OA
Müller C, Alarinta J, Frahm B, Wirtanen G. Microbial spoilage in vegan foods. PBN 2022 Congress. 2022.
ELSA | Download (ext.)
 
[136]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11376
Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. Processes. 2021;9(6).
ELSA | DOI
 
[135]
2021 | Konferenz - Vortrag | ELSA-ID: 7927
Hernández Rodriguez T, Frahm B. Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction. 2021.
ELSA
 
[134]
2021 | Konferenz - Poster | ELSA-ID: 7931
Moser A, Möller J, Kuchemüller KB, Deppe S, Hernández Rodriguez T, Gassenmeier V, et al. Model-assisted Design of Experiments - Concept, Software and Applications. 2021.
ELSA
 
[133]
2021 | Lexikoneintrag | ELSA-ID: 7939
Wirtanen G, Alarinta J, Frahm B, Fasse S. Bovine Colostrum for Human Consumption. In: MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science. 2021.
ELSA
 
[132]
2021 | Sammelwerk - Beitrag | ELSA-ID: 7983
Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing. Basel: MDPI; 2021. p. 49–74. (Processes : open access journal ; vol. special issue).
ELSA | DOI
 
[131]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering. 2021;44(4):793–808.
ELSA | DOI
 
[130]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7986
Moser A, Kuchemüller KB, Deppe S, Hernández Rodriguez T, Frahm B, Pörtner R, et al. Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering. 2021;44(4):683–700.
ELSA | DOI
 
[129]
2021 | Konferenz - Vortrag | ELSA-ID: 8078
Blome A, Luttmann M, Frahm B, Müller U. Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung. Seminar Life Science Technologies 2021-04-28. 2021.
ELSA
 
[128]
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
Hernández Rodriguez T, Frahm B. Digital Seed Train Twins and Statistical Methods. In: Herwig C, Pörtner R, Möller J, editors. Digital Twins Tools and Concepts for Smart Biomanufacturing. Berlin, Heidelberg: Springer; 2021. p. 97–131. (Advances in Biochemical Engineering/Biotechnology; vol. 176).
ELSA | DOI
 
[127]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7981
Fasse S, Alarinta J, Frahm B, Wirtanen G. Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing. Dairy. 2021;2(4):556–75.
ELSA | DOI | WoS
 
[126]
2020 | Konferenz - Poster | ELSA-ID: 7929
Hernández Rodriguez T, Deppe S, Gassenmeier V, Kuhfuß F, Tölle M, Ifrim GA, et al. Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. 2020.
ELSA
 
[125]
2020 | Konferenz - Poster | ELSA-ID: 7930
Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. 2020.
ELSA
 
[124]
2020 | Konferenz - Vortrag | ELSA-ID: 7936
Hernández Rodriguez T, Frahm B, Posch C. Integration of prior knowledge and digital tools for uncertainty-based decision support. 2020.
ELSA
 
[123]
2020 | Konferenzband - Beitrag | ELSA-ID: 7937
Hernández Rodriguez T, Deppe S, Gassenmeier V, Kuhfuß F, Tölle M, Ifrim GA, et al. Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020. Wiley; 2020. (Volume 92; vol. No. 9).
ELSA | DOI
 
[122]
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020. Wiley; 2020. (Volume 92; vol. No. 9).
ELSA | DOI
 
[121]
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
Hernández Rodriguez T, Posch C, Schmutzhard J, Stettner J, Weihs Claus , Pörtner R, et al. Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach. Vol. 14, BMC Proceedings. BioMed Central; 2020.
ELSA | Dateien verfügbar | DOI
 
[120]
2020 | Konferenz - Poster | ELSA-ID: 3007
Kuhfuß F, Tölle M, Hernández Rodriguez T, Gassenmeier V, Deppe S, Ifrim GA, et al. Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. 2020.
ELSA
 
[119]
2020 | Konferenz - Poster | ELSA-ID: 3008
Deppe S, Kuhfuß F, Tölle M, Hernández Rodriguez T, Gassenmeier V, Ifrim GA, et al. Model-assisted Design of Experiments for algae cultivation. 2020.
ELSA
 
[118]
2020 | Konferenz - Poster | ELSA-ID: 3009
Ifrim GA, Deppe S, Hernández Rodriguez T, Gassenmeier V, Frahm B. Modeling of microalgae in an air-lift photobioreactor for biomass production. 2020.
ELSA
 
[117]
2020 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2392
Möller J, Hernández Rodríguez T, Müller J, Arndt L, Kuchemüller KB, Frahm B, et al. Model uncertainty-based evaluation of process strategies during scale-up of biopharmaceutical processes. Computers & Chemical Engineering. 2020;134:1–13.
ELSA | DOI
 
[116]
2020 | Sammelwerk - Beitrag | ELSA-ID: 2397
Hernández Rodríguez T, Frahm B. Design, Optimization and Adaptive Control of Cell Culture Seed Trains. In: Pörtner R, editor. Animal Cell Biotechnology - Methods and Protocols. Berlin, Heidelberg, New York: Springer; 2020. p. 251–67. (Methods in Molecular Biology; vol. 2095).
ELSA | DOI
 
[115]
2020 | Sammelwerk - Beitrag | ELSA-ID: 2399
Deppe S, Frahm B, Hass VC, Hernández Rodríguez T, Kuchemüller KB, Möller J, et al. Estimation of Process Model Parameters. In: Pörtner R, editor. Animal Cell Biotechnology: Methods and Protocols. Berlin ; Heidelberg ; New York: Springer; 2020. p. 213–34. (Methods in Molecular Biology; vol. 2095).
ELSA | DOI
 
[114]
2019 | Konferenz - Vortrag | ELSA-ID: 7928
Frahm B. Scale-up of stirred vessels. 2019.
ELSA
 
[113]
2019 | Konferenz - Vortrag | ELSA-ID: 2956
Möller J, Müller J, Hernández Rodriguez T, Kuchemüller KB, Arndt L, Frahm B, et al. Workflow for model-assisted design and scale-up of biopharmaceutical production processes. 2019.
ELSA
 
[112]
2019 | Konferenz - Vortrag | ELSA-ID: 2957
Möller J, Kuchemüller KB, Moser A, Hass VC, Hernández Rodriguez T, Deppe S, et al. Model-Assisted Design of Experiments. 2019.
ELSA
 
[111]
2019 | Konferenz - Vortrag | ELSA-ID: 2958
Ifrim GA, Titica M, Deppe S, Frahm B, Barbu M, Caraman S. Novel control strategy for microalgae in photobioreactor. 2019.
ELSA
 
[110]
2019 | Konferenz - Poster | ELSA-ID: 3000
Hernández Rodriguez T, Posch C, Schmutzhard J, Stettner J, Weihs J, Pörtner R, et al. Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. 2019.
ELSA
 
[109]
2019 | Konferenz - Poster | ELSA-ID: 3001
Hernández Rodriguez T, Posch C, Schmutzhard J, Stettner J, Weihs J, Pörtner R, et al. Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. 2019.
ELSA
 
[108]
2019 | Konferenz - Poster | ELSA-ID: 3002
Möller J, Kuchemüller KB, Hernández Rodriguez T, Deppe S, Ifrim GA, Moser A, et al. Model-Assisted Design of Experiments – Software Toolbox. 2019.
ELSA
 
[107]
2019 | Konferenz - Poster | ELSA-ID: 3003
Deppe S, Hernández Rodriguez T, Gassenmeier V, Tölle M, Kuhfuß F, Möller J, et al. Model-assisted Design of Experiments for algae cultivation. 2019.
ELSA
 
[106]
2019 | Konferenz - Poster | ELSA-ID: 3004
Ifrim GA, Deppe S, Hernández Rodriguez T, Gassenmeier V, Frahm B. Modeling of microalgae in an air-lift photobioreactor for biomass production. 2019.
ELSA
 
[105]
2019 | Konferenz - Poster | ELSA-ID: 3005
Hernández Rodriguez T, Posch C, Schmutzhard J, Stettner J, Weihs J, Pörtner R, et al. Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. 2019.
ELSA
 
[104]
2019 | Konferenz - Poster | ELSA-ID: 3006
Ifrim GA, Titica M, Deppe S, Frahm B, Barbu M, Caraman S. Multivariable control strategy for the photosynthetic cultures of microalgae. 2019.
ELSA
 
[103]
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 | OA
Hernández Rodriguez T, Posch C, Schmutzhard J, Stettner J, Weihs C, Pörtner R, et al. Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method. Biotechnology and Bioengineering. 2019;116(11):2944–59.
ELSA | DOI | Download (ext.)
 
[102]
2019 | Konferenzband - Beitrag | ELSA-ID: 2400
Ifrim GA, Titica M, Deppe S, Frahm B, Barbu M, Caraman S. Multivariable control strategy for the photosynthetic cultures of microalgae. 2019 23rd International Conference on System Theory, Control and Computing (ICSTCC). IEEE; 2019.
ELSA | DOI
 
[101]
2018 | Konferenz - Vortrag | ELSA-ID: 7935
Hernández Rodriguez T, Frahm B, Posch C, Schmutzhard J, Stettner J. A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization. 2018.
ELSA
 
[100]
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
Hernández Rodriguez T, Krull S, Hass VC, Möller J, Pörtner R, Frahm B. Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. Vol. 112, BMC Proceedings. BioMed Central; 2018.
ELSA | Dateien verfügbar | DOI
 
[99]
2018 | Konferenz - Vortrag | ELSA-ID: 2955
Pörtner R, Möller J, Frahm B, Hass VC. Model-Assisted Design of Process Strategies for Cell Culture Processes. 2018.
ELSA
 
[98]
2018 | Konferenz - Poster | ELSA-ID: 2997
Möller J, Kuchemüller KB, Freiberger F, Levermann P, Hernández Rodriguez T, Frahm B, et al. Model-Assisted Design and Optimization of Process Strategies. 2018.
ELSA
 
[97]
2018 | Konferenz - Poster | ELSA-ID: 2999
Hernández Rodriguez T, Möller J, Kuchemüller KB, Freiberger F, Levermann P, Hass VC, et al. Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses. 2018.
ELSA
 
[96]
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 | OA
Möller J, Kuchemüller KB, Hernández Rodriguez T, Frahm B, Hass VC, Pörtner R. Model-Assisted Design of Process Strategies for Cell Culture Processes. American Pharmaceutical Review. 2018;3:39–41.
ELSA | Download (ext.)
 
[95]
2017 | Konferenz - Vortrag | ELSA-ID: 2920
Hernández Rodriguez T, Kern S, Platas Barradas O, Pörtner R, Frahm B. Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. 2017.
ELSA
 
[94]
2017 | Konferenz - Vortrag | ELSA-ID: 2921
Pörtner R, Möller J, Hernández Rodriguez T, Frahm B, Hass VC. Model-assisted design and optimization of biotechnological processes. 2017.
ELSA
 
[93]
2017 | Konferenz - Vortrag | ELSA-ID: 2950
Hernández Rodriguez T, Koopmann KS, Klaes J, Kern S, Platas Barradas O, Pörtner R, et al. Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. 2017.
ELSA
 
[92]
2017 | Konferenz - Poster | ELSA-ID: 2994
Hernández Rodriguez T, Koopmann KS, Pörtner R, Frahm B. Influence of parameter accuracies in cell culture seed train simulations. 2017.
ELSA
 
[91]
2017 | Konferenz - Poster | ELSA-ID: 2995
Hernández Rodriguez T, Krull S, Hass VC, Möller J, Pörtner R, Frahm B. Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. 2017.
ELSA
 
[90]
2017 | Konferenz - Poster | ELSA-ID: 2996
Hernández Rodriguez T, Krull S, Hass VC, Pörtner R, Frahm B. Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. 2017.
ELSA
 
[89]
2016 | Konferenz - Poster | ELSA-ID: 2991
Beshay U, Feldt S, Schwarze B, Wefing P, Hahne T, Moschinski J, et al. DMA Photobioreactor System – Cultivation at low shear stress and optional membrane aeration. 2016.
ELSA
 
[88]
2016 | Konferenz - Poster | ELSA-ID: 2992
Hernández Rodriguez T, Vörtler S, Kern S, Platas Barradas O, Pörtner R, Frahm B. A software tool for biopharmaceutical seed train design and optimization. 2016.
ELSA
 
[87]
2016 | Konferenz - Poster | ELSA-ID: 2993
Koopmann KS, Hernández Rodriguez T, Vörtler S, Beshay U, Möller J, Pörtner R, et al. Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies. 2016.
ELSA
 
[86]
2016 | Sammelwerk - Beitrag | ELSA-ID: 2395
Pörtner R, Platas Barradas O, Frahm B, Hass VC. Advanced Process and Control Strategies for Bioreactors. In: Current Developments in Biotechnology and Bioengineering: Bioprocesses, Bioreactors and Controls. Amsterdam: Elsevier; 2016. p. 463–93.
ELSA | DOI
 
[85]
2015 | Konferenzband - Beitrag | ELSA-ID: 2819 | OA
Hernández Rodriguez T, Pörtner R, Frahm B. Considerations for cell passaging in cell culture seed trains. Vol. 9, BMC proceedings / BioMed Central. BioMed Central; 2015.
ELSA | DOI | Download (ext.)
 
[84]
2015 | Konferenzband - Beitrag | ELSA-ID: 2820 | OA
Kern S, Platas Barradas O, Schaletzky M, Sandig V, Frahm B, Pörtner R. Model-based strategy for cell culture seed train layout verified at lab scale. Vol. 9, BMC proceedings / BioMed Central. BioMed Central; 2015.
ELSA | DOI | Download (ext.)
 
[83]
2015 | Konferenz - Vortrag | ELSA-ID: 2917
Frahm B, Pörtner R, Kern S, Hernández Rodriguez T. Seed train design and optimization for animal cell suspension culture. 2015.
ELSA | Dateien verfügbar
 
[82]
2015 | Konferenz - Vortrag | ELSA-ID: 2919
Frahm B, Hernández Rodriguez T, Kern S, Koopmann KS, Beshay U, Platas-Barradas O, et al. Seed train design and optimization for animal cell suspension culture. 2015.
ELSA
 
[81]
2015 | Konferenz - Poster | ELSA-ID: 2985
Hernández Rodriguez T, Pörtner R, Frahm B. Considerations for cell passaging in cell culture seed trains. 2015.
ELSA
 
[80]
2015 | Konferenz - Poster | ELSA-ID: 2986
Kern S, Platas O, Schaletzky M, Sandig V, Frahm B, Pörtner R. Model-based strategy for cell culture seed train layout verified at lab scale. 2015.
ELSA
 
[79]
2015 | Konferenz - Poster | ELSA-ID: 2987
Hernández Rodriguez T, Pörtner R, Frahm B. A software tool for biopharmaceutical seed train design and optimization. 2015.
ELSA
 
[78]
2015 | Konferenz - Poster | ELSA-ID: 2988
Hernández Rodriguez T, Pörtner R, Frahm B. Considerations for cell passaging in cell culture seed trains. 2015.
ELSA
 
[77]
2015 | Konferenz - Poster | ELSA-ID: 2990
Kern S, Platas O, Schaletzky M, Sandig V, Frahm B, Pörtner R. Model-based strategy for cell culture seed train layout verified at lab scale. 2015.
ELSA
 
[76]
2015 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2389
Kern S, Platas-Barradas O, Pörtner R, Frahm B. Model-based strategy for cell culture seed train layout verified at lab scale. Cytotechnology. 2015;68(4):1019–32.
ELSA | DOI | Download (ext.)
 
[75]
2014 | Patent | ELSA-ID: 2878
Frahm B, Meier U. Beleuchtung von disposable Bioreaktoren. 2014.
ELSA
 
[74]
2014 | Konferenz - Poster | ELSA-ID: 2984
Drews F, Drews G, Folz C, Platz G, Gassenmeier T, Kramer M, et al. Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche. 2014.
ELSA
 
[73]
2014 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2388
Hahne T, Schwarze B, Kramer M, Frahm B. Disposable algae cultivation for high-value products using all around LED-illumination directly on the bags. Journal of Algal Biomass Utilization. 2014;5(2):66–73.
ELSA
 
[72]
2013 | Konferenzband - Beitrag | ELSA-ID: 2817 | OA
Hernández Rodriguez T, Pörtner R, Frahm B. Seed train optimization for suspension cell culture. Vol. 7, BMC proceedings / BioMed Central . BioMed Central ; 2013.
ELSA | DOI | Download (ext.)
 
[71]
2013 | Konferenzband - Beitrag | ELSA-ID: 2818 | OA
Kern S, Platas O, Schaletzky M, Sandig V, Frahm B, Pörtner R. Model-based design of the first steps of a seed train for cell culture processes. Vol. 7, BMC proceedings / BioMed Central . BioMed Central; 2013.
ELSA | DOI | Download (ext.)
 
[70]
2013 | Konferenz - Poster | ELSA-ID: 2980
Kern S, Platas O, Schaletzky M, Sandig V, Frahm B, Pörtner R. Modellgestützte Auslegung der ersten Schritte eines Seed-Trains für Zellkulturprozesse. 2013.
ELSA
 
[69]
2013 | Konferenz - Poster | ELSA-ID: 2981
Kern S, Platas O, Schaletzky M, Sandig V, Frahm B, Pörtner R. Model-based design of the first steps of a seed train for cell culture processes. 2013.
ELSA
 
[68]
2013 | Konferenz - Poster | ELSA-ID: 2982
Hahne T, Schwarze B, Moschinski J, Kuttig A, Kramer M, Frahm B. Disposable Algenkultivierung für hochpreisige Produkte mittels LED-Rundumbeleuchtung direkt auf den Bags. 2013.
ELSA
 
[67]
2013 | Konferenz - Poster | ELSA-ID: 2983
Hernández Rodriguez T, Pörtner R, Frahm B. Seed train optimization for suspension cell culture. 2013.
ELSA
 
[66]
2013 | Sammelwerk - Beitrag | ELSA-ID: 10214
Frahm B. Seed Train Optimization for Cell Culture. In: Pörtner R, editor. Animal Cell Biotechnology - Methods and Protocols. 3rd ed. Totowa, NJ: Humana Press; 2013. p. 355–67. (Methods in Molecular Biology; vol. 1104).
ELSA | DOI
 
[65]
2012 | Konferenzband - Beitrag | ELSA-ID: 2816 | OA
Frahm B, Brod H. Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA). Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009. Dordrecht: Springer; 2012. (ESACT Proceedings; vol. 5).
ELSA | DOI | Download (ext.)
 
[64]
2012 | Patent | ELSA-ID: 2877
Brod H, Frahm B. Photobioreaktor mit rotatorisch oszillierenden Lichtquellen. 2012.
ELSA
 
[63]
2012 | Konferenz - Vortrag | ELSA-ID: 2918
Van Hecke W, Haltrich D, Frahm B, Brod H, Ludwig R. Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. Achema 2012. Vogel Business Media; 2012.
ELSA
 
[62]
2012 | Konferenz - Poster | ELSA-ID: 2973
Marzougui R, Pörtner R, Frahm B. Optimierung des Seed trains von Suspensions-Zellkulturen. 2012.
ELSA
 
[61]
2011 | Patent | ELSA-ID: 2876
Brod H, Frahm B, Jenne M, Kauling J, Schmitt F, Seletzky J. Flüssigkeitsbegaser. 2011.
ELSA
 
[60]
2011 | Konferenz - Poster | ELSA-ID: 2972
Van Hecke W, Haltrich D, Frahm B, Brod H, Ludwig R. Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. 2011.
ELSA
 
[59]
2011 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2350
Van Hecke W, Haltrich D, Frahm B, Brod H, Dewulf J, Van Langenhove H, et al. A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor. Journal of Molecular Catalysis B: Enzymatic. 2011;68(2):154–61.
ELSA | DOI | Download (ext.)
 
[58]
2010 | Konferenzband - Beitrag | ELSA-ID: 2815
Dercks B, Frahm B, Grünewald M, Kenig E, Lautenschleger A, Gorak A, et al. Intensified absorption and distillation devices for modular chemical production processes. Proceedings 19th International Congress of Chemical and Process Engineering. Czech Society of Chemical Engineering; 2010.
ELSA
 
[57]
2010 | Patent | ELSA-ID: 2873
Brod H, Frahm B, Kauling J. Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen. 2010.
ELSA
 
[56]
2010 | Patent | ELSA-ID: 2874
Brod H, Frahm B, Jenne M, Kauling J. Bioreaktor. 2010.
ELSA
 
[55]
2010 | Patent | ELSA-ID: 2875
Frahm B, Kauling J, Pütz A, Schindler M. Begasungssystem. 2010.
ELSA
 
[54]
2010 | Konferenz - Vortrag | ELSA-ID: 2892
Frahm B, Brod H. Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration. 2010.
ELSA
 
[53]
2010 | Konferenz - Vortrag | ELSA-ID: 2913
Dercks B, Frahm B, Grünewald M, Kenig E, Lautenschleger A, Gorak A, et al. Intensified absorption and distillation devices for modular chemical production processes. 2010.
ELSA
 
[52]
2009 | Patent | ELSA-ID: 2872
Braun A, Brod H, Frahm B, Jenne M, Kauling J, Kirchner S. Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen. 2009.
ELSA
 
[51]
2009 | Konferenz - Vortrag | ELSA-ID: 2912
Frahm B, Brod H, Langer U. Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA). 2009.
ELSA
 
[50]
2009 | Konferenz - Poster | ELSA-ID: 2970
Frahm B, Brod H, Langer U. Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA). 2009.
ELSA
 
[49]
2009 | Konferenz - Poster | ELSA-ID: 2971
Van Hecke W, Van Langenhovve H, Frahm B, Brod H, Dewulf J, Haltrich D, et al. Upscaling the biocatalytic conversion of lactose to lactobionic acid with the dynamic membrane aeration reactor. 2009.
ELSA
 
[48]
2009 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2349 | OA
Frahm B, Brod H, Langer U. Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration. Cytotechnology. 2009;59(1):17–30.
ELSA | DOI | Download (ext.)
 
[47]
2008 | Konferenz - Vortrag | ELSA-ID: 2911
Brod H, Kauling J, Frahm B, Jenne M, Langer U, Bödeker B. Pushing the Limits in High-Density Mammalian Cell Fermentation. 2008.
ELSA
 
[46]
2008 | Konferenz - Poster | ELSA-ID: 2968
Frahm B, Brod H, Burnett M, Langer U, Bödeker B. High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA). 2008.
ELSA
 
[45]
2008 | Konferenz - Poster | ELSA-ID: 2969
Frahm B, Brod H. High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA). 2008.
ELSA
 
[44]
2007 | Konferenzband - Beitrag | ELSA-ID: 2814
Pörtner R, Frahm B, Lane P, Munack A, Kühn K, Hass VC. Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller. Cell Technology for Cell Products. Dordrecht: Springer; 2007. (ESACT Proceedings; vol. 3).
ELSA | DOI
 
[43]
2007 | Patent | ELSA-ID: 2870 | OA
Brod H, Frahm B, Kauling J, Rose R. Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component. 2007.
ELSA | Download (ext.)
 
[42]
2007 | Patent | ELSA-ID: 2871
Brod H, Frahm B, Kauling J, Poggel M, Rose R, Schmidt S. Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen. 2007.
ELSA
 
[41]
2007 | Konferenz - Vortrag | ELSA-ID: 2909
Brod H, Frahm B, Kauling J. Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. 2007.
ELSA
 
[40]
2007 | Konferenz - Vortrag | ELSA-ID: 2910
Brod H, Frahm B, Kauling J. Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. 2007.
ELSA
 
[39]
2007 | Konferenz - Poster | ELSA-ID: 2967
Frahm B, Kirchner S, Rose R, Jenne M, Kauling J, Brod H, et al. High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA). 2007.
ELSA
 
[38]
2007 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2348
Frahm B, Kirchner S, Kauling J, Brod H, Langer U, Bödeker B. Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien. Chemie Ingenieur Technik. 2007;79(7):1052–8.
ELSA | DOI | Download (ext.)
 
[37]
2005 | Konferenzband - Beitrag | ELSA-ID: 2813
Frahm B, Pörtner R. Flexible Fed-Batch Process Control of Animal Cells. Animal Cell Technology Meets Genomics. Dordrecht: Springer; 2005. (ESACT Proceedings; vol. 2).
ELSA | DOI
 
[36]
2005 | Konferenz - Vortrag | ELSA-ID: 2907
Pörtner R, Frahm B, Lane P, Munack A. Optimisation of time-space-yield for hybridoma fed-batch cultures with an adaptive OLFO-controller. 2005.
ELSA
 
[35]
2005 | Konferenz - Vortrag | ELSA-ID: 2908
Pörtner R, Frahm B, Hass VC, Lane P, Munack A. Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. 2005.
ELSA
 
[34]
2005 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2347 | OA
Frahm B, Lane P, Munack A, Pörtner R. Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. Chemie Ingenieur Technik. 2005;77(4):429–35.
ELSA | DOI | Download (ext.)
 
[33]
2004 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2345 | OA
Pörtner R, Schwabe J-O, Frahm B. Evaluation of selected control strategies for fed-batch cultures of a hybridoma cell line. Biotechnology and Applied Biochemistry. 2004;40.
ELSA | DOI | Download (ext.)
 
[32]
2003 | Konferenz - Vortrag | ELSA-ID: 7934
Frahm B, Pörtner R. Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies. 2003.
ELSA
 
[31]
2003 | Konferenzband - Beitrag | ELSA-ID: 2435
Frahm B, Müller-Landré B, Wiggers de Almeida G, Singer M, Rausch M, Lane P, et al. Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control. Beckmann D, Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld), editors. Technische Systeme für Biotechnologie und Umwelt. Heiligenstadt: Inst. für Bioprozess- und Analysenmesstechnik ; 2003.
ELSA
 
[30]
2003 | Konferenzband - Beitrag | ELSA-ID: 2436
Kühn K, Frahm B, Pörtner R, Lane P, Munack A, Hass VC. Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells. European Federation of Chemical Engineering, editor. Vol. 10, ECCE - 4th European Congress of Chemical Engineering. Granada: ECCE4; 2003.
ELSA
 
[29]
2003 | Konferenz - Vortrag | ELSA-ID: 2902
Frahm B, Pörtner R. Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung. 2003.
ELSA
 
[28]
2003 | Konferenz - Vortrag | ELSA-ID: 2903
Hass VC, Kühn K, Frahm B, Pörtner R, Lane P, Munack A. Ein strukturiertes Kompartiment-Modell zur Beschreibung der Kultivierung von Hybridomazellen als Teil einer adaptiven, modellgestützten Prozessführung. 2003.
ELSA
 
[27]
2003 | Konferenz - Vortrag | ELSA-ID: 2905
Frahm B, Lane P, Munack A, Hass VC, Pörtner R. Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies. 2003.
ELSA | Dateien verfügbar
 
[26]
2003 | Konferenz - Vortrag | ELSA-ID: 2906
Pörtner R, Frahm B, Lane P, Hass VC, Munack A, Märkl H. Fed-Batch-Kultivierung tierischer Zellen – eine Herausforderung für eine adaptive, modellgestützte Steuerung. 2003.
ELSA
 
[25]
2003 | Konferenz - Poster | ELSA-ID: 2964
Frahm B, Pörtner R. CO2-off-gas measurement for animal cell culture processes. 2003.
ELSA
 
[24]
2003 | Konferenz - Poster | ELSA-ID: 2965
Frahm B, Pörtner R. Flexible fed-batch process control of animal cells. 2003.
ELSA
 
[23]
2003 | Konferenz - Poster | ELSA-ID: 2966
Kühn K, Frahm B, Pörtner R, Lane P, Munack A, Hass VC. Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells. 2003.
ELSA
 
[22]
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2343 | OA
Frahm B, Hass VC, Lane P, Munack A, Märkl H, Pörtner R. Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung. Chemie Ingenieur Technik. 2003;75(4):457–60.
ELSA | DOI | Download (ext.)
 
[21]
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2344 | OA
Frahm B, Lane P, Märkl H, Pörtner R. Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis. Bioprocess and Biosystems Engineering. 2003;26(1):1–10.
ELSA | DOI | Download (ext.)
 
[20]
2003 | Dissertation | ELSA-ID: 2393
Frahm B. Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Norderstedt: Books on Demand GmbH; 2003. 120 p.
ELSA
 
[19]
2002 | Konferenzband - Beitrag | ELSA-ID: 2431
Frahm B, Pörtner R. Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen. Kaden H, Forum Innovative Biosystemtechnik - Sensorik, Aktorik und Auswertung Biotechnologischer Prozesse (2001 : Waldheim), editors. Biosystemtechnik: Innovative Biosystemtechnik - Sensorik, Aktorik und Auswertung biotechnologischer Prozesse. Meinsberg : Kurt-Schwabe-Inst. ; 2002.
ELSA
 
[18]
2002 | Konferenz - Vortrag | ELSA-ID: 2897
Frahm B, Pörtner R. Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen. 2002.
ELSA
 
[17]
2002 | Konferenz - Vortrag | ELSA-ID: 2898
Frahm B, Pörtner R. Adaptive, model-based control by the OLFO-controller for the fed-batch cultivation of animal cells. 2002.
ELSA
 
[16]
2002 | Konferenz - Vortrag | ELSA-ID: 2899
Frahm B, Pörtner R. Adaptive, model-based control by the OLFO-controller for the fed-batch cultivation of animal cells. 2002.
ELSA
 
[15]
2002 | Konferenz - Vortrag | ELSA-ID: 2900
Frahm B, Müller-Landré B, Wiggers de Almeida G, Singer M, Rausch M, Lane P, et al. Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control. 2002.
ELSA
 
[14]
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2340 | OA
Frahm B, Blank H-C, Cornand P, Oelßner W, Guth U, Lane P, et al. Determination of dissolved CO2 concentration and CO2 production rate of mammalian cell suspension culture based on off-gas measurement. Journal of Biotechnology. 2002;99(2):133–48.
ELSA | DOI | Download (ext.)
 
[13]
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2341 | OA
Frahm B, Lane P, Atzert H, Munack A, Hoffmann M, Hass VC, et al. Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Effective Fed-Batch Cultivation of Hybridoma Cells. Biotechnology Progress. 2002;18(5):1095–103.
ELSA | DOI | Download (ext.)
 
[12]
2002 | Zeitschriftenaufsatz | ELSA-ID: 2342
Frahm B, Pörtner R. Reaktor-Abgasmessungen bei Zellkulturen. BIOforum. 2002;4:179–80.
ELSA
 
[11]
2001 | Konferenz - Vortrag | ELSA-ID: 7933
Frahm B, Pörtner R. Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen. 2001.
ELSA
 
[10]
2001 | Konferenzband - Beitrag | ELSA-ID: 2427
Frahm B, Atzert H, Lane P, Hoffmann M, Hass VC, Munack A, et al. Development of an Automated, Adaptive Model-Based Control for the Effective Cultivation of Hybridoma Cells. Animal Cell Technology: From Target to Market. Dordrecht: Springer; 2001. (ESACT Proceedings; vol. 1).
ELSA | DOI
 
[9]
2001 | Konferenz - Poster | ELSA-ID: 2429
Hass VC, Lane P, Hoffmann M, Frahm B, Schwabe J-O, Pörtner R, et al. Model-Based Control of Hybridoma Cell Cultures. 2001.
ELSA
 
[8]
2001 | Konferenz - Vortrag | ELSA-ID: 2894
Hoffmann M, Hass VC, Frahm B, Schwabe J-O, Pörtner R, Lane P, et al. Untersuchung verschiedener mathematischer Modelle in Hinblick auf ihre Eignung für die adaptive Prozessführung von Hybridoma Zellkulturen. 2001.
ELSA
 
[7]
2001 | Konferenz - Vortrag | ELSA-ID: 2895
Frahm B, Pörtner R. Arbeitsschwerpunkte TUHH, Bioprozess- und Bioverfahrenstechnik, Arbeitsgruppe Zellkulturtechnik. 2001.
ELSA
 
[6]
2001 | Konferenz - Poster | ELSA-ID: 2960
Frahm B, Atzert H, Schwabe J-O, Lane P, Munack A, Hoffmann M, et al. Adaptive modellgestützte Steuerung von Zellkulturprozessen. 2001.
ELSA
 
[5]
2001 | Konferenz - Poster | ELSA-ID: 2961
Lane P, Frahm B, Atzert H, Schwabe J-O, Hoffmann M, Hass VC, et al. Design of Feeding Strategies for Fed-Batch Cultures of Animal Cells by the Method of Inequalities. 2001.
ELSA
 
[4]
2001 | Konferenz - Poster | ELSA-ID: 2962
Frahm B, Atzert H, Lane P, Hoffmann M, Hass VC, Munack A, et al. Development of an automated, model-based, adaptive control for the effective cultivation of hybridoma cells. 2001.
ELSA
 
[3]
2001 | Konferenzband - Beitrag | ELSA-ID: 2963 | OA
Hass VC, Lane P, Hoffmann M, Frahm B, Schwabe J-O, Pörtner R, et al. Model-Based Control of Hybridoma Cell Cultures. Published for the International Federation of Automatic Control by Pergamon , editor. Computer Applications in Biotechnology, 2001: Modelling, Monitoring and Control of Biotechnological Processes. Oxford: ScienceDirect; 2001. (  IFAC Proceedings Volumes / IFAC, International Federation of Automatic Control; vol. 34).
ELSA | DOI | Download (ext.)
 
[2]
2000 | Konferenz - Vortrag | ELSA-ID: 2893
Anderelei T, Frahm B, Büchs J. Online-Bestimmung der Sauerstofftransferrate (OTR) und der Kohlendioxidtransferrate (CTR) in geschüttelten Bioreaktoren. 2000.
ELSA
 
[1]
2000 | Konferenz - Poster | ELSA-ID: 2959
Hoffmann M, Frahm B, Schwabe J-O, Lane P, Pörtner R, Hass VC, et al. Modellgestützte Prozessführung für Hybridoma-Kulturen mit Hilfe des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus. 2000.
ELSA
 
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